Výsledky vyhledávání - "Ari E. Berman"

Akademický článek

A genome-scale RNA-interference screen identifies RRAS signaling as a pathologic feature of Huntington's disease.

Autor: John P Miller, Bridget E Yates, Ismael Al-Ramahi, Ari E Berman, Mario Sanhueza, Eugene Kim, Maria de Haro, Francesco DeGiacomo, Cameron Torcassi, Jennifer Holcomb, Juliette Gafni, Sean D Mooney, Juan Botas, Lisa M Ellerby, Robert E Hughes

Publikováno v: PLoS Genetics, Vol 8, Iss 11, p e1003042 (2012)

A genome-scale RNAi screen was performed in a mammalian cell-based assay to identify modifiers of mutant huntingtin toxicity. Ontology analysis of suppressor data identified processes previously implicated in Huntington's disease, including proteolys

Externí odkaz: https://doaj.org/article/175b1e0ba3254567b62e13171c7342da

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The medical science DMZ: a network design pattern for data-intensive medical science

Autor: Eli Dart, Anurag Shankar, Robert L. Grossman, William K. Barnett, Ari E. Berman, James Cuff, Sean Peisert, Brian Tierney, Edward Balas

Publikováno v: Journal of the American Medical Informatics Association : JAMIA

Objective We describe a detailed solution for maintaining high-capacity, data-intensive network flows (eg, 10, 40, 100 Gbps+) in a scientific, medical context while still adhering to security and privacy laws and regulations. Materials and Methods Hi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0d904a244dbc5fe27b6ebed0e5b8495b
https://doi.org/10.1093/jamia/ocx104

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Bioinformatics Analyses Reveal Age-Specific Neuroimmune Modulation as a Target for Treatment of High Ethanol Drinking

Autor: Yukun Chen, Benjamin D. Colvard, Jonathan Nguyen, Rajiv G. Agrawal, Ryan J. Hogue, Ari E. Berman, Yazan M. Al-Hasan, Anna Kate Fowler, Patricia S. Levin, Peter J. Syapin, Yuri A. Blednov, Susan E. Bergeson, Oscar Velasquez, Aveline Hewetson, Scott R. Franklin, Chris Walz, Julie A. Owen

Publikováno v: Alcoholism: Clinical and Experimental Research. 38:428-437

Alcoholism is a complex trait involving the interaction of numerous biological and environmental factors. In the past several decades, researchers have convincingly elucidated that, for a disease of such complexity as alcoholism, no single molecular

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c15448687b1dade0961634c59008905a
https://doi.org/10.1111/acer.12288

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The Medical Science DMZ

Autor: Ari E. Berman, Brian Tierney, Eli Dart, James Cuff, Edward Balas, Anurag Shankar, Robert L. Grossman, Sean Peisert, William K. Barnett

Publikováno v: Journal of the American Medical Informatics Association : JAMIA

Objective We describe use cases and an institutional reference architecture for maintaining high-capacity, data-intensive network flows (e.g., 10, 40, 100 Gbps+) in a scientific, medical context while still adhering to security and privacy laws and r

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c506d2f89c3f08d14b22b1cae923ebcc
https://pubmed.ncbi.nlm.nih.gov/27136944

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Nuclear Factor Erythroid 2-Related Factor 2 Facilitates Neuronal Glutathione Synthesis by Upregulating Neuronal Excitatory Amino Acid Transporter 3 Expression

Autor: Jeffrey A. Johnson, Nicole Déglon, Gwennaelle Auregan, Carole Escartin, Seok Joon Won, Sang Won Suh, Raymond A. Swanson, Ari E. Berman, Pei Chun Chen, Carole Malgorn

Publikováno v: Journal of Neuroscience
Journal of Neuroscience, Society for Neuroscience, 2011, 31 (20), pp.7392-7401. ⟨10.1523/JNEUROSCI.6577-10.2011⟩
Journal of Neuroscience, 2011, 31 (20), pp.7392-7401. ⟨10.1523/JNEUROSCI.6577-10.2011⟩

Astrocytes support neuronal antioxidant capacity by releasing glutathione, which is cleaved to cysteine in brain extracellular space. Free cysteine is then taken up by neurons through excitatory amino acid transporter 3 [EAAT3; also termed Slc1a1 (so

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7fef3fe67e2477f33921df04f0763bcb
https://doi.org/10.1523/jneurosci.6577-10.2011

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N-acetylcysteine prevents loss of dopaminergic neurons in theEAAC1−/−mouse

Autor: Ylva Edling, Sang Won Suh, Raymond A. Swanson, Wai Yee Chan, Ari E. Berman, A. Brennan, L B S Brittany Adler, Tiina M. Kauppinen, Reno C. Reyes

Publikováno v: Annals of Neurology. 69:509-520

Parkinson’s disease (PD) leads to cell death in several neuronal populations, particularly the dopaminergic neurons of the substantia nigra pars compacta (SNc). Between 5% and 10% of PD can now be attributed to heritable genetic mutations, but the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a6a4e93797a5186c86dec6d847f75761
https://doi.org/10.1002/ana.22162

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Expression Profiling in Alcoholism Research

Autor: Joanne Marie Lewohl, Peter R. Dodd, Wolfgang H. Sommer, Susan E. Bergeson, Robert J. Hitzemann, Howard J. Edenberg, Kerrie H. Lodowski, Ari E. Berman

Publikováno v: Alcoholism: Clinical & Experimental Research. 29:1066-1073

This article represents the proceedings of a symposium at the 2004 International Society for Biomedical Research on Alcoholism in Mannheim, Germany, organized and co-chaired by Susan E. Bergeson and Wolfgang Sommer. The presentations and presenter we

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::99a3fe157c1d708b211210de622b2318
https://doi.org/10.1097/01.alc.0000171043.29384.3e

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