Zobrazeno 1 - 10 of 70 pro vyhledávání: '"Arhancet GB"'
1
Akademický článek
Identification of (R)-6-(1-(4-cyano-3-methylphenyl)-5-cyclopentyl-4,5-dihydro-1H-pyrazol-3-yl)-2-methoxynicotinic acid, a highly potent and selective nonsteroidal mineralocorticoid receptor antagonist.
Autor: Casimiro-Garcia A; Pfizer Worldwide Research and Development , 200 CambridgePark Drive, Cambridge, Massachusetts 02140, United States., Piotrowski DW, Ambler C, Arhancet GB, Banker ME, Banks T, Boustany-Kari CM, Cai C, Chen X, Eudy R, Hepworth D, Hulford CA, Jennings SM, Loria PM, Meyers MJ, Petersen DN, Raheja NK, Sammons M, She L, Song K, Vrieze D, Wei L
Publikováno v: Journal of medicinal chemistry [J Med Chem] 2014 May 22; Vol. 57 (10), pp. 4273-88. Date of Electronic Publication: 2014 Apr 30.
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2
Akademický článek
In silico investigation of novel 5-benzylidene-2-(arylsulfonylhydrazono)thiazolidine-4-ones as potential inhibitors of mPGES-1 and COX-2.
Autor: KULABAŞ, Necla1 necla.kulabas@marmara.edu.tr
Publikováno v: Journal of Research in Pharmacy. 2023, Vol. 27 Issue 5, p2124-2134. 11p.
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3
Akademický článek
Inactivation of mitochondrial pyruvate carrier promotes NLRP3 inflammasome activation and gout development via metabolic reprogramming.
Autor: Chen, Lih‐Chyang1 (AUTHOR), Chen, Yu‐Jen1,2,3,4,5 (AUTHOR), Lin, Hsin‐An6,7 (AUTHOR), Chien, Wu‐Chien8,9,10 (AUTHOR), Tsai, Kuen‐Jou11,12 (AUTHOR), Chung, Chi‐Hsiang8,13 (AUTHOR), Wang, Jui‐Yang14 (AUTHOR), Chen, Chien‐Chou15 (AUTHOR), Liao, Nan‐Shih16 (AUTHOR), Shih, Chieh‐Tien1 (AUTHOR), Lin, Yi‐Ying12 (AUTHOR), Huang, Chi‐Ning1 (AUTHOR), Ojcius, David M.17 (AUTHOR), Huang, Kuo‐Yang18 (AUTHOR), Lin, Hsin‐Chung18,19 (AUTHOR) hsinchunglin@gmail.com
Publikováno v: Immunology. Jul2023, Vol. 169 Issue 3, p271-291. 21p.
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4
Akademický článek
Discovery and SAR of PF-4693627, a potent, selective and orally bioavailable mPGES-1 inhibitor for the potential treatment of inflammation.
Autor: Arhancet GB; Pfizer Worldwide Medicinal Chemistry, Pfizer, Inc., 700 Chesterfield Parkway West, Chesterfield, MO 63017, USA. graciela.arhancet@novusint.com, Walker DP, Metz S, Fobian YM, Heasley SE, Carter JS, Springer JR, Jones DE, Hayes MJ, Shaffer AF, Jerome GM, Baratta MT, Zweifel B, Moore WM, Masferrer JL, Vazquez ML
Publikováno v: Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 2013 Feb 15; Vol. 23 (4), pp. 1114-9. Date of Electronic Publication: 2012 Dec 06.
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5
Akademický článek
Synthesis and biological evaluation of substituted benzoxazoles as inhibitors of mPGES-1: use of a conformation-based hypothesis to facilitate compound design.
Autor: Walker DP; Pfizer Worldwide Medicinal Chemistry, Pfizer Inc., 700 Chesterfield Parkway West, Chesterfield, MO 63017, USA. dpwalker@kalexsyn.com, Arhancet GB, Lu HF, Heasley SE, Metz S, Kablaoui NM, Franco FM, Hanau CE, Scholten JA, Springer JR, Fobian YM, Carter JS, Xing L, Yang S, Shaffer AF, Jerome GM, Baratta MT, Moore WM, Vazquez ML
Publikováno v: Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 2013 Feb 15; Vol. 23 (4), pp. 1120-6. Date of Electronic Publication: 2012 Dec 12.
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6
Akademický článek
Discovery of novel cyanodihydropyridines as potent mineralocorticoid receptor antagonists.
Autor: Arhancet GB; St. Louis Laboratories, Pfizer Global Research and Development, Pfizer, Inc., 700 Chesterfield Parkway West, St. Louis, Missouri 63017, USA. graciela.arhancet@novusint.com, Woodard SS, Iyanar K, Case BL, Woerndle R, Dietz JD, Garland DJ, Collins JT, Payne MA, Blinn JR, Pomposiello SI, Hu X, Heron MI, Huang HC, Lee LF
Publikováno v: Journal of medicinal chemistry [J Med Chem] 2010 Aug 26; Vol. 53 (16), pp. 5970-8.
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7
Akademický článek
Discovery of (3S,3aR)-2-(3-chloro-4-cyanophenyl)-3-cyclopentyl-3,3a,4,5-tetrahydro-2H-benzo[g]indazole-7-carboxylic acid (PF-3882845), an orally efficacious mineralocorticoid receptor (MR) antagonist for hypertension and nephropathy.
Autor: Meyers MJ; St. Louis Laboratories, Pfizer Global Research and Development, Pfizer, Inc., 700 Chesterfield Parkway West, Chesterfield, Missouri 63017, USA. mmeyers8@slu.edu, Arhancet GB, Hockerman SL, Chen X, Long SA, Mahoney MW, Rico JR, Garland DJ, Blinn JR, Collins JT, Yang S, Huang HC, McGee KF, Wendling JM, Dietz JD, Payne MA, Homer BL, Heron MI, Reitz DB, Hu X
Publikováno v: Journal of medicinal chemistry [J Med Chem] 2010 Aug 26; Vol. 53 (16), pp. 5979-6002.
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8
Akademický článek
Stereochemical requirements for the mineralocorticoid receptor antagonist activity of dihydropyridines.
Autor: Arhancet GB; Pfizer Global Research & Development, St. Louis Laboratories, Pfizer Inc., St. Louis, Missouri 63017, USA. grace.arhancet@gmail.com, Woodard SS, Dietz JD, Garland DJ, Wagner GM, Iyanar K, Collins JT, Blinn JR, Numann RE, Hu X, Huang HC
Publikováno v: Journal of medicinal chemistry [J Med Chem] 2010 May 27; Vol. 53 (10), pp. 4300-4.
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9
Akademický článek
Insulin sensitizing pharmacology of thiazolidinediones correlates with mitochondrial gene expression rather than activation of PPAR gamma.
Autor: Bolten CW; Discovery Research, Pfizer Corporation, 700 Chesterfield Parkway, West Chesterfield, MO 63017, USA. charles.w.bolten@pfizer.com, Blanner PM, McDonald WG, Staten NR, Mazzarella RA, Arhancet GB, Meier MF, Weiss DJ, Sullivan PM, Hromockyj AE, Kletzien RF, Colca JR
Publikováno v: Gene regulation and systems biology [Gene Regul Syst Bio] 2007 Sep 17; Vol. 1, pp. 73-82. Date of Electronic Publication: 2007 Sep 17.
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10
Akademický článek
Thiazolidinediones inhibit the progression of established hypertension in the Dahl salt-sensitive rat.
Autor: Bolten CW; Discovery Research, Pfizer Corporation, 700 Chesterfield Parkway West, Chesterfield, MO 63017, USA. charles.w.bolten@pfizer.com, Payne MA, McDonald WG, Blanner PM, Chott RC, Ghosh S, Arhancet GB, Staten NR, Gulve EA, Sullivan PM, Hromockyj AE, Colca JR
Publikováno v: Diabetes & vascular disease research [Diab Vasc Dis Res] 2007 Jun; Vol. 4 (2), pp. 117-23.
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