NMR Analysis Suggests Synergy between the RRM2 and the Carboxy-Terminal Segment of Human La Protein in the Recognition and Interaction with HCV IRES.

Autor: Argyriou AI; Department of Pharmacy, University of Patras, GR-26504 Patras, Greece., Machaliotis GA; Department of Pharmacy, University of Patras, GR-26504 Patras, Greece., Makrynitsa GI; Department of Pharmacy, University of Patras, GR-26504 Patras, Greece., Kaliatsi EG; Department of Biochemistry, School of Medicine, University of Patras, GR-26504 Patras, Greece., Stathopoulos C; Department of Biochemistry, School of Medicine, University of Patras, GR-26504 Patras, Greece., Spyroulias GA; Department of Pharmacy, University of Patras, GR-26504 Patras, Greece.

Publikováno v: International journal of molecular sciences [Int J Mol Sci] 2023 Jan 29; Vol. 24 (3). Date of Electronic Publication: 2023 Jan 29.

Binding Adaptation of GS-441524 Diversifies Macro Domains and Downregulates SARS-CoV-2 de-MARylation Capacity.

Autor: Tsika AC; Department of Pharmacy, University of Patras, GR-26504 Patras, Greece. Electronic address: https://twitter.com/@katerina_tsika., Gallo A; Department of Pharmacy, University of Patras, GR-26504 Patras, Greece. Electronic address: https://twitter.com/@AngeloGallo83., Fourkiotis NK; Department of Pharmacy, University of Patras, GR-26504 Patras, Greece., Argyriou AI; Department of Pharmacy, University of Patras, GR-26504 Patras, Greece., Sreeramulu S; Institute for Organic Chemistry and Chemical Biology, Center for Biomolecular Magnetic Resonance, Johann Wolfgang Goethe-University Frankfurt, Max-von-Laue-Str. 7, 60438 Frankfurt am Main, Germany., Löhr F; Institute for Biophysical Chemistry, Center for Biomolecular Magnetic Resonance, Johann Wolfgang Goethe-University Frankfurt, Max-von-Laue-Str. 9, 60438 Frankfurt am Main, Germany., Rogov VV; Structural Genomics Consortium (SGC), Buchmann Institute for Molecular Life Sciences, Max-von-Laue-Str. 15, 60438 Frankfurt am Main, Germany; Institute of Pharmaceutical Chemistry, Johann Wolfgang Goethe University Frankfurt, Max-von-Laue-Str. 9, 60438 Frankfurt am Main, Germany., Richter C; Institute for Organic Chemistry and Chemical Biology, Center for Biomolecular Magnetic Resonance, Johann Wolfgang Goethe-University Frankfurt, Max-von-Laue-Str. 7, 60438 Frankfurt am Main, Germany., Linhard V; Institute for Organic Chemistry and Chemical Biology, Center for Biomolecular Magnetic Resonance, Johann Wolfgang Goethe-University Frankfurt, Max-von-Laue-Str. 7, 60438 Frankfurt am Main, Germany., Gande SL; Institute for Organic Chemistry and Chemical Biology, Center for Biomolecular Magnetic Resonance, Johann Wolfgang Goethe-University Frankfurt, Max-von-Laue-Str. 7, 60438 Frankfurt am Main, Germany., Altincekic N; Institute for Organic Chemistry and Chemical Biology, Center for Biomolecular Magnetic Resonance, Johann Wolfgang Goethe-University Frankfurt, Max-von-Laue-Str. 7, 60438 Frankfurt am Main, Germany., Krishnathas R; Institute for Organic Chemistry and Chemical Biology, Center for Biomolecular Magnetic Resonance, Johann Wolfgang Goethe-University Frankfurt, Max-von-Laue-Str. 7, 60438 Frankfurt am Main, Germany., Elamri I; Institute for Organic Chemistry and Chemical Biology, Center for Biomolecular Magnetic Resonance, Johann Wolfgang Goethe-University Frankfurt, Max-von-Laue-Str. 7, 60438 Frankfurt am Main, Germany., Schwalbe H; Institute for Organic Chemistry and Chemical Biology, Center for Biomolecular Magnetic Resonance, Johann Wolfgang Goethe-University Frankfurt, Max-von-Laue-Str. 7, 60438 Frankfurt am Main, Germany. Electronic address: schwalbe@nmr.uni-frankfurt.de., Wollenhaupt J; Macromolecular Crystallography, Helmholtz-Zentrum Berlin, Albert-Einstein-Straße 15, D-12489 Berlin, Germany. Electronic address: https://twitter.com/@Jan_Wollenhaupt., Weiss MS; Macromolecular Crystallography, Helmholtz-Zentrum Berlin, Albert-Einstein-Straße 15, D-12489 Berlin, Germany. Electronic address: https://twitter.com/@ManfredSWeiss., Spyroulias GA; Department of Pharmacy, University of Patras, GR-26504 Patras, Greece. Electronic address: G.A.Spyroulias@upatras.gr.

Publikováno v: Journal of molecular biology [J Mol Biol] 2022 Aug 30; Vol. 434 (16), pp. 167720. Date of Electronic Publication: 2022 Jul 15.

Replacement of heme by soluble guanylate cyclase (sGC) activators abolishes heme-nitric oxide/oxygen (H-NOX) domain structural plasticity.

Autor: Argyriou AI; Department of Pharmacy, University of Patras, GR-26504, Patras, Greece., Makrynitsa GI; Department of Pharmacy, University of Patras, GR-26504, Patras, Greece., Dalkas G; Department of Pharmacy, University of Patras, GR-26504, Patras, Greece., Georgopoulou DA; Department of Pharmacy, University of Patras, GR-26504, Patras, Greece., Salagiannis K; Laboratory of Molecular Pharmacology, Department of Pharmacy, University of Patras, 26504, Patras, Greece., Vazoura V; Laboratory of Molecular Pharmacology, Department of Pharmacy, University of Patras, 26504, Patras, Greece., Papapetropoulos A; Laboratory of Pharmacology, Faculty of Pharmacy, National and Kapodistrian University of Athens, Athens, Greece., Topouzis S; Laboratory of Molecular Pharmacology, Department of Pharmacy, University of Patras, 26504, Patras, Greece., Spyroulias GA; Department of Pharmacy, University of Patras, GR-26504, Patras, Greece.

Publikováno v: Current research in structural biology [Curr Res Struct Biol] 2021 Nov 18; Vol. 3, pp. 324-336. Date of Electronic Publication: 2021 Nov 18 (Print Publication: 2021).

Backbone and side chain NMR assignments of the H-NOX domain from Nostoc sp. in complex with BAY58-2667 (cinaciguat).

Autor: Makrynitsa GI; Department of Pharmacy, University of Patras, 26504, Patras, Greece., Argyriou AI; Department of Pharmacy, University of Patras, 26504, Patras, Greece., Dalkas G; Department of Pharmacy, University of Patras, 26504, Patras, Greece., Georgopoulou DA; Department of Pharmacy, University of Patras, 26504, Patras, Greece., Bantzi M; Institut für Organische Chemie, Universität Leipzig, Johannisallee 29, 04103, Leipzig, Germany.; Department of Chemistry, University of Fribourg, Chemin du Musée 9, 1700, Fribourg, Switzerland., Giannis A; Institut für Organische Chemie, Universität Leipzig, Johannisallee 29, 04103, Leipzig, Germany., Papapetropoulos A; Laboratory of Pharmacology, Faculty of Pharmacy, National and Kapodistrian University of Athens, Athens, Greece., Spyroulias GA; Department of Pharmacy, University of Patras, 26504, Patras, Greece. G.A.Spyroulias@upatras.gr.

Publikováno v: Biomolecular NMR assignments [Biomol NMR Assign] 2021 Apr; Vol. 15 (1), pp. 53-57. Date of Electronic Publication: 2020 Oct 30.

Therapeutic Targeting of the Soluble Guanylate Cyclase.

Autor: Makrynitsa GI; Department of Pharmacy, School of Health Sciences, University of Patras, Rio, 26505, Greece., Zompra AA; Department of Pharmacy, School of Health Sciences, University of Patras, Rio, 26505, Greece., Argyriou AI; Department of Pharmacy, School of Health Sciences, University of Patras, Rio, 26505, Greece., Spyroulias GA; Department of Pharmacy, School of Health Sciences, University of Patras, Rio, 26505, Greece., Topouzis S; Department of Pharmacy, School of Health Sciences, University of Patras, Rio, 26505, Greece.

Publikováno v: Current medicinal chemistry [Curr Med Chem] 2019; Vol. 26 (15), pp. 2730-2747.