Zobrazeno 1 - 10
of 3 353
pro vyhledávání: '"Argun A"'
Autor:
Turcin Saridogan, Argun Akcakanat, Ming Zhao, Kurt W. Evans, Erkan Yuca, Stephen Scott, Bryce P. Kirby, Xiaofeng Zheng, Min Jin Ha, Huiqin Chen, Patrick K. S. Ng, Timothy P. DiPeri, Gordon B. Mills, Jordi Rodon Ahnert, Senthil Damodaran, Funda Meric-Bernstam
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-15 (2023)
Abstract Several alterations in fibroblast growth factor receptor (FGFR) genes have been found in breast cancer; however, they have not been well characterized as therapeutic targets. Futibatinib (TAS-120; Taiho) is a novel, selective, pan-FGFR inhib
Externí odkaz:
https://doaj.org/article/54d8ba5ed19745f68237d1d74ca99a08
Autor:
Ming Zhao, Timothy P. DiPeri, Maria Gabriela Raso, Xiaofeng Zheng, Yasmeen Qamar Rizvi, Kurt W. Evans, Fei Yang, Argun Akcakanat, Marco Roberto Estecio, Debu Tripathy, Ecaterina E. Dumbrava, Senthil Damodaran, Funda Meric-Bernstam
Publikováno v:
npj Breast Cancer, Vol 9, Iss 1, Pp 1-14 (2023)
Abstract TROP2 antibody drug conjugates (ADCs) are under active development. We seek to determine whether we can enhance activity of TROP2 ADCs by increasing TROP2 expression. In metaplastic breast cancers (MpBC), there is limited expression of TROP2
Externí odkaz:
https://doaj.org/article/153c2e942072429c8da59c33c6ea4273
Autor:
Seyed Pairawan, Argun Akcakanat, Scott Kopetz, Coya Tapia, Xiaofeng Zheng, Huiqin Chen, Min Jin Ha, Yasmeen Rizvi, Vijaykumar Holla, Jing Wang, Kurt W. Evans, Ming Zhao, Naifa Busaidy, Bingliang Fang, Jack A. Roth, Ecaterina Ileana Dumbrava, Funda Meric-Bernstam
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-15 (2022)
Abstract Most tumors with activating MAPK (mitogen-activated protein kinase) pathway alterations respond poorly to MEK inhibitors alone. Here, we evaluated combination therapy with MEK inhibitor selumetinib and MDM2 inhibitor KRT-232 in TP53 wild-typ
Externí odkaz:
https://doaj.org/article/51b40b75a51c478a93d56c2bf88693c8
Our research investigates the challenges Deep Reinforcement Learning (DRL) faces in complex, Partially Observable Markov Decision Processes (POMDP) such as autonomous driving (AD), and proposes a solution for vision-based navigation in these environm
Externí odkaz:
http://arxiv.org/abs/2409.10554
Autor:
Seyed Pairawan, Ming Zhao, Erkan Yuca, Allen Annis, Kurt Evans, David Sutton, Luis Carvajal, Jian-Guo Ren, Solimar Santiago, Vincent Guerlavais, Argun Akcakanat, Coya Tapia, Fei Yang, Priya Subash Chandra Bose, Xiaofeng Zheng, Ecaterina Ileana Dumbrava, Manuel Aivado, Funda Meric-Bernstam
Publikováno v:
Breast Cancer Research, Vol 23, Iss 1, Pp 1-15 (2021)
Abstract Background MDM2/MDMX proteins are frequently elevated in hormone receptor-positive (ER+) breast cancer. We sought to determine the antitumor efficacy of the combination of ALRN-6924, a dual inhibitor of MDM2/MDMX, with chemotherapy in ER+ br
Externí odkaz:
https://doaj.org/article/c251cacd8a6e4763988dbd3811b83598
Autor:
Yan Xing, Nancy U. Lin, Matthew A. Maurer, Huiqin Chen, Armeen Mahvash, Aysegul Sahin, Argun Akcakanat, Yisheng Li, Vandana Abramson, Jennifer Litton, Mariana Chavez-MacGregor, Vicente Valero, Sarina A. Piha-Paul, David Hong, Kim-Anh Do, Emily Tarco, Dianna Riall, Agda Karina Eterovic, Gerburg M. Wulf, Lewis C. Cantley, Gordon B. Mills, L. Austin Doyle, Eric Winer, Gabriel N. Hortobagyi, Ana Maria Gonzalez-Angulo, Funda Meric-Bernstam
Publikováno v:
Breast Cancer Research, Vol 21, Iss 1, Pp 1-12 (2019)
Abstract Background The PI3K/AKT pathway is activated through PIK3CA or AKT1 mutations and PTEN loss in breast cancer. We conducted a phase II trial with an allosteric AKT inhibitor MK-2206 in patients with advanced breast cancer who had tumors with
Externí odkaz:
https://doaj.org/article/3eaaeb80b88d4c81acd24e596bc7212d
Rigid bodies, made of smaller composite beads, are commonly used to simulate anisotropic particles with molecular dynamics or Monte Carlo methods. To accurately represent the particle shape and to obtain smooth and realistic effective pair interactio
Externí odkaz:
http://arxiv.org/abs/2402.12199
Autor:
Natalia Paez Arango, Erkan Yuca, Ming Zhao, Kurt W. Evans, Stephen Scott, Charissa Kim, Ana Maria Gonzalez-Angulo, Filip Janku, Naoto T. Ueno, Debu Tripathy, Argun Akcakanat, Aung Naing, Funda Meric-Bernstam
Publikováno v:
Breast Cancer Research, Vol 19, Iss 1, Pp 1-10 (2017)
Abstract Background Selinexor (KPT-330) is an oral agent that has been shown to inhibit the nuclear exporter XPO1. Given the pressing need for novel therapies for triple-negative breast cancer (TNBC), we sought to determine the antitumor effects of s
Externí odkaz:
https://doaj.org/article/aa1049178cee4907862f726c8c7667ec
Publikováno v:
Turkish Journal of Agriculture: Food Science and Technology, Vol 5, Iss 4, Pp 335-342 (2017)
In this study, Bomolochus unicirrus Brian, 1902, a species of parasitic copepod belonging to the family Bomolochidae (Claus, 1875), was reported for the first time from the north-eastern Mediterranean waters off the Turkish coast. Parasites were coll
Externí odkaz:
https://doaj.org/article/7cf5b70c3f15490abe75bbaca2f0e70d
Autor:
Bahar Argun Karslı, Ebru Demir
Publikováno v:
Turkish Journal of Agriculture: Food Science and Technology, Vol 12, Iss 9, Pp 1577-1582 (2024)
Alfa S1 kazein (CSN1S1) ve CKLF benzeri MARVEL transmembran alanı içeren protein 2 (CMTM2) gen bölgelerinde meydana gelen insersiyon ve delesyon (InDel) gibi varyasyonlar keçilerde bir batında doğan yavru sayısını etkileyebilmektedir. Bu ça
Externí odkaz:
https://doaj.org/article/ead56e60da404285aa4f236a408da2e4