Clinicopathological Implications of ASAP1 Expression in Hepatocellular Carcinoma

Autor: Seongsik Bang, Seungyun Jee, Hwangkyu Son, Hyebin Cha, Jongmin Sim, Yeseul Kim, Hosub Park, Jaekyung Myung, Hyunsung Kim, Seungsam Paik

Publikováno v: Pathology and Oncology Research, Vol 28 (2022)

Background: The expression of ArfGAP with SH3 domain ankyrin repeat and PH domain 1 (ASAP1) is increased in various types of cancer, showing potential as a prognostic marker. The clinicopathological implications of ASAP1 expression in patients with h

Externí odkaz: https://doaj.org/article/e85a337e0c414b5495a543b8a1b5ccc6

Interaction of the N terminus of ADP-ribosylation factor with the PH domain of the GTPase-activating protein ASAP1 requires phosphatidylinositol 4,5-bisphosphate.

Autor: Roy NS; Laboratory of Cellular and Molecular Biology, Center for Cancer Research, NCI, National Institutes of Health, Bethesda, Maryland 20892., Jian X; Laboratory of Cellular and Molecular Biology, Center for Cancer Research, NCI, National Institutes of Health, Bethesda, Maryland 20892., Soubias O; Structural Biophysics Laboratory, Center for Cancer Research, NCI, National Institutes of Health, Frederick, Maryland 21702., Zhai P; Laboratory of Cellular and Molecular Biology, Center for Cancer Research, NCI, National Institutes of Health, Bethesda, Maryland 20892., Hall JR; Chemical Genomics Center, National Center for Advancing Translational Sciences, National Institutes of Health, Bethesda, Maryland 20892., Dagher JN; Chemical Genomics Center, National Center for Advancing Translational Sciences, National Institutes of Health, Bethesda, Maryland 20892., Coussens NP; Chemical Genomics Center, National Center for Advancing Translational Sciences, National Institutes of Health, Bethesda, Maryland 20892., Jenkins LM; Laboratory of Cell Biology, Center for Cancer Research, NCI, National Institutes of Health, Bethesda, Maryland 20892., Luo R; Laboratory of Cellular and Molecular Biology, Center for Cancer Research, NCI, National Institutes of Health, Bethesda, Maryland 20892., Akpan IO; Laboratory of Cellular and Molecular Biology, Center for Cancer Research, NCI, National Institutes of Health, Bethesda, Maryland 20892., Hall MD; Chemical Genomics Center, National Center for Advancing Translational Sciences, National Institutes of Health, Bethesda, Maryland 20892., Byrd RA; Structural Biophysics Laboratory, Center for Cancer Research, NCI, National Institutes of Health, Frederick, Maryland 21702., Yohe ME; Laboratory of Cellular and Molecular Biology, Center for Cancer Research, NCI, National Institutes of Health, Bethesda, Maryland 20892 Marielle.Yohe@nih.gov.; Pediatric Oncology Branch, Center for Cancer Research, NCI, National Institutes of Health, Bethesda, Maryland 20892., Randazzo PA; Laboratory of Cellular and Molecular Biology, Center for Cancer Research, NCI, National Institutes of Health, Bethesda, Maryland 20892 randazzp@mail.nih.gov.

Publikováno v: The Journal of biological chemistry [J Biol Chem] 2019 Nov 15; Vol. 294 (46), pp. 17354-17370. Date of Electronic Publication: 2019 Oct 06.