Transcriptomic profiling of the myeloma bone-lining niche reveals BMP signalling inhibition to improve bone disease

Autor: Gooding, S, Olechnowicz, S, Morris, E, Armitage, A, Arezes, J, Frost, J, Repapi, E, Edwards, J, Ashley, N, Waugh, C, Gray, N, Martinez-Hackert, Lim, PJ, Pasricha, S-R, Knowles, H, Mead, A, Ramasamy, K, Drakesmith, A, Edwards, C

Publikováno v: Nature Communications, Vol 10, Iss 1, Pp 1-15 (2019)
Nature Communications

Multiple myeloma is an incurable, bone marrow-dwelling malignancy that disrupts bone homeostasis causing skeletal damage and pain. Mechanisms underlying myeloma-induced bone destruction are poorly understood and current therapies do not restore lost

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::d02ec4333d03bc93048716befbaaf676
http://link.springer.com/article/10.1038/s41467-019-12296-1

Hepcidin is regulated by promoter-associated histone acetylation and HDAC3

Autor: Pasricha, S., Lim, P., Duarte, T., Casu, C., Oosterhuis, D., Mleczko-Sanecka, K., Suciu, M., Da Silva, A., Al-Hourani, K., Arezes, J., McHugh, K., Gooding, S., Frost, J., Wray, K., Santos, A., Porto, G., Repapi, E., Gray, N., Draper, S., Ashley, N., Soilleux, E., Olinga, P., Muckenthaler, M., Hughes, J., Rivella, S., Milne, T., Armitage, A., Drakesmith, H.

Publikováno v: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Agência para a Sociedade do Conhecimento (UMIC)-FCT-Sociedade da Informação
instacron:RCAAP
Nature Communications, Vol 8, Iss 1, Pp 1-15 (2017)
Nature Communications
Nature Communications, 8:403. Nature Publishing Group

Hepcidin regulates systemic iron homeostasis. Suppression of hepcidin expression occurs physiologically in iron deficiency and increased erythropoiesis but is pathologic in thalassemia and hemochromatosis. Here we show that epigenetic events govern h

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::3a577ab42681837e522023a5969b4483

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