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Akademický článek

Whole-exome sequencing to identify causative variants in juvenile sudden cardiac death

Autor: Martina Modena, Alberto Giannoni, Alberto Aimo, Paolo Aretini, Nicoletta Botto, Simona Vittorini, Andrea Scatena, Diana Bonuccelli, Marco Di Paolo, Michele Emdin

Publikováno v: Human Genomics, Vol 18, Iss 1, Pp 1-18 (2024)

Abstract Background Juvenile sudden cardiac death (SCD) remains unexplained in approximately 40% of cases, leading to a significant emotional burden for the victims’ families and society. Comprehensive investigations are essential to uncover its el

Externí odkaz: https://doaj.org/article/cc80cff76de340ce8860c84178dcae7f

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Akademický článek

Comparative analysis of genetic variants in pleural fluids and solid tissue biopsies of pleural mesothelioma patients: Implications for molecular heterogeneity assessment

Autor: Roberto Silvestri, Filomena Rea, Marianna Vitiello, Gabriele Moretti, Vittorio Aprile, Marco Lucchi, Paolo Aretini, Chiara Maria Mazzanti, Stefano Landi, Federica Gemignani

Publikováno v: Heliyon, Vol 10, Iss 11, Pp e32152- (2024)

Objectives: This study aims to determine whether the sequencing of DNA extracted from pleural fluids (PFs) of Pleural Mesothelioma (PM) patients accurately represents the genetic information obtained from the solid tissue counterpart biopsies with pa

Externí odkaz: https://doaj.org/article/4e2a57cd4d2047b8b378ebb94f5af9b0

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Akademický článek

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Akademický článek

A molecular computational model improves the preoperative diagnosis of thyroid nodules

Autor: Tomei Sara, Marchetti Ivo, Zavaglia Katia, Lessi Francesca, Apollo Alessandro, Aretini Paolo, Di Coscio Giancarlo, Bevilacqua Generoso, Mazzanti Chiara

Publikováno v: BMC Cancer, Vol 12, Iss 1, p 396 (2012)

Abstract Background Thyroid nodules with indeterminate cytological features on fine needle aspiration (FNA) cytology have a 20% risk of thyroid cancer. The aim of the current study was to determine the diagnostic utility of an 8-gene assay to disting

Externí odkaz: https://doaj.org/article/041b2c06269c47da957d477ff8661bfd

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Akademický článek

c-KIT receptor expression is strictly associated with the biological behaviour of thyroid nodules

Autor: Tomei Sara, Mazzanti Chiara, Marchetti Ivo, Rossi Leonardo, Zavaglia Katia, Lessi Francesca, Apollo Alessandro, Aretini Paolo, Di Coscio Giancarlo, Bevilacqua Generoso

Publikováno v: Journal of Translational Medicine, Vol 10, Iss 1, p 7 (2012)

Abstract Background A large amount of information has been collected on the molecular tumorigenesis of thyroid cancer. A low expression of c-KIT gene has been reported during the transformation of normal thyroid epithelium to papillary carcinoma sugg

Externí odkaz: https://doaj.org/article/edca921d0d174d4d8f3348b6d54e1df6

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Akademický článek

Exploring Regorafenib Responsiveness and Uncovering Molecular Mechanisms in Recurrent Glioblastoma Tumors through Longitudinal In Vitro Sampling

Autor: Mariangela Morelli, Francesca Lessi, Sara Franceschi, Gianmarco Ferri, Manuel Giacomarra, Michele Menicagli, Carlo Gambacciani, Francesco Pieri, Francesco Pasqualetti, Nicola Montemurro, Paolo Aretini, Orazio Santo Santonocito, Anna Luisa Di Stefano, Chiara Maria Mazzanti

Publikováno v: Cells, Vol 13, Iss 6, p 487 (2024)

Glioblastoma, a deadly brain tumor, shows limited response to standard therapies like temozolomide (TMZ). Recent findings from the REGOMA trial underscore a significant survival improvement offered by Regorafenib (REGO) in recurrent glioblastoma. Our

Externí odkaz: https://doaj.org/article/cb05bb8548ac4d87af3236dc9cdad224

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