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Akademický článek

Whole-exome sequencing to identify causative variants in juvenile sudden cardiac death

Autor: Martina Modena, Alberto Giannoni, Alberto Aimo, Paolo Aretini, Nicoletta Botto, Simona Vittorini, Andrea Scatena, Diana Bonuccelli, Marco Di Paolo, Michele Emdin

Publikováno v: Human Genomics, Vol 18, Iss 1, Pp 1-18 (2024)

Abstract Background Juvenile sudden cardiac death (SCD) remains unexplained in approximately 40% of cases, leading to a significant emotional burden for the victims’ families and society. Comprehensive investigations are essential to uncover its el

Externí odkaz: https://doaj.org/article/cc80cff76de340ce8860c84178dcae7f

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Akademický článek

Comparative analysis of genetic variants in pleural fluids and solid tissue biopsies of pleural mesothelioma patients: Implications for molecular heterogeneity assessment

Autor: Roberto Silvestri, Filomena Rea, Marianna Vitiello, Gabriele Moretti, Vittorio Aprile, Marco Lucchi, Paolo Aretini, Chiara Maria Mazzanti, Stefano Landi, Federica Gemignani

Publikováno v: Heliyon, Vol 10, Iss 11, Pp e32152- (2024)

Objectives: This study aims to determine whether the sequencing of DNA extracted from pleural fluids (PFs) of Pleural Mesothelioma (PM) patients accurately represents the genetic information obtained from the solid tissue counterpart biopsies with pa

Externí odkaz: https://doaj.org/article/4e2a57cd4d2047b8b378ebb94f5af9b0

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Akademický článek

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Akademický článek

Exploring Regorafenib Responsiveness and Uncovering Molecular Mechanisms in Recurrent Glioblastoma Tumors through Longitudinal In Vitro Sampling

Autor: Mariangela Morelli, Francesca Lessi, Sara Franceschi, Gianmarco Ferri, Manuel Giacomarra, Michele Menicagli, Carlo Gambacciani, Francesco Pieri, Francesco Pasqualetti, Nicola Montemurro, Paolo Aretini, Orazio Santo Santonocito, Anna Luisa Di Stefano, Chiara Maria Mazzanti

Publikováno v: Cells, Vol 13, Iss 6, p 487 (2024)

Glioblastoma, a deadly brain tumor, shows limited response to standard therapies like temozolomide (TMZ). Recent findings from the REGOMA trial underscore a significant survival improvement offered by Regorafenib (REGO) in recurrent glioblastoma. Our

Externí odkaz: https://doaj.org/article/cb05bb8548ac4d87af3236dc9cdad224

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