Whole exome sequencing reveals diverse genomic relatedness between paired concurrent endometrial and ovarian carcinomas

Autor: Southworth, Emily, Thomson, John P., Croy, Ian, Churchman, Michael, Arends, Mark J., Hollis, Robert L., Gourley, Charlie, Herrington, C. Simon

Publikováno v: In European Journal of Cancer September 2024 208

Multi-Omic Analysis of Esophageal Adenocarcinoma Uncovers Candidate Therapeutic Targets and Cancer-Selective Posttranscriptional Regulation

Autor: Fitzgerald, Rebecca C., Edwards, Paul A.W., Grehan, Nicola, Nutzinger, Barbara, Loreno, Christine, Redmond, Aisling M., Abbas, Sujath, Freeman, Adam, Smyth, Elizabeth C., O'Donovan, Maria, Miremadi, Ahmad, Malhotra, Shalini, Tripathi, Monika, Cheah, Calvin, Coles, Hannah, Millington, Curtis, Devonshire, Ginny, Eldridge, Matthew, Secrier, Maria, Jammula, Sriganesh, Davies, Jim, Crichton, Charles, Carroll, Nick, Hardwick, Richard H., Safranek, Peter, Hindmarsh, Andrew, Sujendran, Vijayendran, Hayes, Stephen J., Ang, Yeng, Sharrocks, Andrew, Preston, Shaun R., Bagwan, Izhar, Save, Vicki, Skipworth, Richard J.E., Hupp, Ted R., O'Neill, J Robert, Tucker, Olga, Beggs, Andrew, Taniere, Philippe, Puig, Sonia, Contino, Gianmarco, Underwood, Timothy J., Walker, Robert C., Grace, Ben L., Lagergren, Jesper, Gossage, James, Davies, Andrew, Chang, Fuju, Mahadeva, Ula, Goh, Vicky, Ciccarelli, Francesca D., Sanders, Grant, Berrisford, Richard, Chan, David, Cheong, Ed, Kumar, Bhaskar, Sreedharan, L., Parsons, Simon L., Soomro, Irshad, Kaye, Philip, Saunders, John, Lovat, Laurence, Haidry, Rehan, Scott, Michael, Sothi, Sharmila, Lishman, Suzy, Hanna, George B., Peters, Christopher J., Moorthy, Krishna, Grabowska, Anna, Turkington, Richard, McManus, Damian, Coleman, Helen, Petty, Russell D., Bartlet, Freddie, O'Neill, J. Robert, Yébenes Mayordomo, Marcos, Mitulović, Goran, Al Shboul, Sofian, Bedran, Georges, Faktor, Jakub, Hernychova, Lenka, Uhrik, Lukas, Gómez-Herranz, Maria, Kocikowski, Mikołaj, Vojtěšek, Bořivoj, Arends, Mark J., Hupp, Ted, Alfaro, Javier Antonio

Publikováno v: In Molecular & Cellular Proteomics June 2024 23(6)

Increased tumorigenesis associated with loss of the tumor suppressor gene Cadm1

Autor: van der Weyden Louise, Arends Mark J, Rust Alistair G, Poulogiannis George, McIntyre Rebecca E, Adams David J

Publikováno v: Molecular Cancer, Vol 11, Iss 1, p 29 (2012)

Abstract Background CADM1 encodes an immunoglobulin superfamily (IGSF) cell adhesion molecule. Inactivation of CADM1, either by promoter hypermethylation or loss of heterozygosity, has been reported in a wide variety of tumor types, thus it has been

Externí odkaz: https://doaj.org/article/b922722f13f645a48f55c4e4b0a6a3f4

Dietary, lifestyle and clinicopathological factors associated with BRAF and K-ras mutations arising in distinct subsets of colorectal cancers in the EPIC Norfolk study

Autor: McTaggart Alison, Ball Richard Y, Luben Robert N, Cooke James C, Gay Laura J, Mitrou Panagiota N, Naguib Adam, Arends Mark J, Rodwell Sheila A

Publikováno v: BMC Cancer, Vol 10, Iss 1, p 99 (2010)

Abstract Background BRAF and K-ras proto-oncogenes encode components of the ERK signalling pathway and are frequently mutated in colorectal cancer. This study investigates the associations between BRAF and K-ras mutations and clinicopathological, lif

Externí odkaz: https://doaj.org/article/abe749387f7a465785c0ea2ee700d858

Differential expression of selected histone modifier genes in human solid cancers

Autor: Bowtell David, Collins V Peter, Arends Mark J, Subkhankulova Tanya, Burtt Glynn, Veerakumarasivam Abhi, Bobrow Linda, Blenkiron Cherie, Hyland Sarah J, Ahmed Ahmed, Teschendorff Andrew E, Özdağ Hilal, Kouzarides Tony, Brenton James D, Caldas Carlos

Publikováno v: BMC Genomics, Vol 7, Iss 1, p 90 (2006)

Abstract Background Post-translational modification of histones resulting in chromatin remodelling plays a key role in the regulation of gene expression. Here we report characteristic patterns of expression of 12 members of 3 classes of chromatin mod

Externí odkaz: https://doaj.org/article/8f7061a988c14c21be1f9d1c58e2aa51