Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Arend Brinkman"'
Autor:
Ramakrishna, A-L Børresen-Dale, M.E. Meijer-van Gelder, Alain Viari, Adam Butler, M.J. van de Vijver, Reno Debets, Henk Stunnenberg, Ewan Birney, Anne Louise Richardson, Germán Fg Rodríguez-González, Arend Brinkman, Marcel Smid, A van Galen, Kim Berentsen, Serena Nik-Zainal, Jwm Martens, HD Davies, J.A. Foekens, AM Sieuwerts, Wjc Prager-Van der Smissen, Markus Ringnér, M van der Vlugt – Daane, Stewart G. Martin, Johan Staaf, Chm van Deurzen, Michael R. Stratton, Carlos Caldas
Publikováno v:
Cancer Research. 76:P6-08
A comprehensive whole genome analysis of a large breast cancer cohort of 560 cases (Nik-Zainal et al, submitted 2015) reports novel and existing DNA substitution and rearrangement signatures next a comprehensive list of events driving the breast canc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::be927b13324dfee19b4e3b4a15b79e9e
https://doi.org/10.1158/1538-7445.sabcs15-p6-08-10
https://doi.org/10.1158/1538-7445.sabcs15-p6-08-10
Background: The presence of multiple, low-molecular-weight, insulinlike growth factor (IGF)-binding proteins in lung tumor cell-conditioned medium and lung cancer patient serum has been recently reported. Purpose: To begin to elucidate the genetic ba
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0a2cb0c1f99a67a327afe2d54156d64d
http://doc.rero.ch/record/300010/files/84-8-628.pdf
http://doc.rero.ch/record/300010/files/84-8-628.pdf
Autor:
Koen J. Dechering, Ton van Agthoven, Lambert C. J. Dorssers, Marcel Smid, Jos Veldscholte, Arend Brinkman
Publikováno v:
Breast Cancer Research, 7(1), R82-R92. BioMed Central Ltd.
Breast Cancer Research
Breast Cancer Research
Introduction Tamoxifen is effective for endocrine treatment of oestrogen receptor-positive breast cancers but ultimately fails due to the development of resistance. A functional screen in human breast cancer cells identified two BCAR genes causing oe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7c99247ab8010a3f34e3adea8b1474f5
https://hdl.handle.net/1765/13635
https://hdl.handle.net/1765/13635
Autor:
D. de Jong, Jan G. M. Klijn, H. Portengen, Doorléne T. H. van Tienoven, Fred C. G. J. Sweep, Simone P. J. van Broekhoven, Lambert C. J. Dorssers, Nicolai Grebenchtchikov, Paul N. Span, H. A. Peters, Arend Brinkman, Marion E. Meijer-van Gelder, John A. Foekens, Anneke Geurts-Moespot, Maxime P. Look
Publikováno v:
Clinical Cancer Research, 10, 18 Pt 1, pp. 6194-202
Clinical Cancer Research, 10, 6194-6202. American Association for Cancer Research Inc.
Clinical Cancer Research, 10, 6194-202
Clinical Cancer Research, 10, 6194-6202. American Association for Cancer Research Inc.
Clinical Cancer Research, 10, 6194-202
Purpose: BCAR1, the human homologue of the rat p130Cas protein, was identified in a functional screen for human breast cancer cell proliferation resistant to antiestrogen drugs. Here, we study the prognostic value of quantitative BCAR1 levels in a la
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4740c7b3086949f8b422e1dc8f53f957
https://doi.org/10.1158/1078-0432.ccr-04-0444
https://doi.org/10.1158/1078-0432.ccr-04-0444
Autor:
Arend Brinkman, T.H. van der Kwast, S. van der Flier, Lambert C. J. Dorssers, John A. Foekens, Mieke Timmermans, S. C. Henzen-Logmans, C. Claassen
Publikováno v:
International Journal of Biological Markers, 16(3), 172-178. Wichtig Publishing Srl
BCAR1/p130Cas is a docking protein involved in intracellular signaling pathways and in vitro resistance of estrogen-dependent breast cancer cells to antiestrogens. The BCAR1/p130Cas protein level in primary breast cancer cytosols was found to correla
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2a20178872b35ddf6745460ac2b17ede
https://pure.eur.nl/en/publications/33fa0a5a-cbe7-4c12-aeae-8d7d0786f26d
https://pure.eur.nl/en/publications/33fa0a5a-cbe7-4c12-aeae-8d7d0786f26d
Autor:
John A. Foekens, Jan G. M. Klijn, Arend Brinkman, Marion E. Meijer-van Gelder, Maxime P. Look, Elisabath M. Kok, Silvia van der Flier, Lambert C. J. Dorssers
Publikováno v:
JNCI: Journal of the National Cancer Institute. 92:120-127
The product of the Bcar1/p130Cas (breast cancer resistance/p130Crk-associated substrate) gene causes resistance to antiestrogen drugs in human breast cancer cells in vitro. To investigate its role in clinical breast cancer, we determined the levels o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f5fcba4fc826831900ecc8a4b19ebd62
https://doi.org/10.1093/jnci/92.2.120
https://doi.org/10.1093/jnci/92.2.120
Autor:
Marcel Smid, Stephen R. D. Johnston, Arend Brinkman, Mitchell Dowsett, Christina M.W. Chan, Lambert C. J. Dorssers, Silvia van der Flier
Publikováno v:
International Journal of Cancer. 89:465-468
High BCAR1/p130Cas expression in primary breast tumour cytosol predicts a poor chance of response recurrent disease to tamoxifen treatment in patients with oestrogen receptor (ER)–positive breast carcinomas. In this study, we assessed whether BCAR1
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9933a1f9ac721f2c0c9fabdf76f4fc86
https://doi.org/10.1002/1097-0215(20000920)89:5<465::aid-ijc11>3.0.co
https://doi.org/10.1002/1097-0215(20000920)89:5<465::aid-ijc11>3.0.co
Publikováno v:
Endocrine Related Cancer. 2:123-126
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1c73e119bea813c39e3b22af3dce94f4
https://doi.org/10.1677/erc.0.0020123
https://doi.org/10.1677/erc.0.0020123
Autor:
Lambert C. J. Dorssers, Anieta M. Sieuwerts, John A. Foekens, Jos Veldscholte, Arend Brinkman, I M Leroy, M.E. Meijer-van Gelder, A.T. den Dekker, W F J van IJcken, T van Agthoven, Stefan Sleijfer, Marcel Smid
Publikováno v:
British Journal of Cancer
British Journal of Cancer, 101(11), 1824-1832. Nature Publishing Group
British Journal of Cancer, 101(11), 1824-1832. Nature Publishing Group
BACKGROUND: Endocrine therapies of breast cancer are effective but ultimately fail because of the development of treatment resistance. We have previously revealed several genes leading to tamoxifen resistance in vitro by retroviral insertion mutagene
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::81c8af56807b798afa322bca2064b5a7
https://pubmed.ncbi.nlm.nih.gov/19904269
https://pubmed.ncbi.nlm.nih.gov/19904269
Autor:
Danielle de Jong, Ton van Agthoven, Sietske Tuinman, Lambert C. J. Dorssers, Arend Brinkman, Najat Azaouagh
Publikováno v:
Breast Cancer Research and Treatment, 120(2), 401-408. Springer New York
To unravel the mechanisms underlying failure of endocrine therapy of breast cancer, we have previously executed a functional genetic screen and identified the adaptor protein BCAR1 to be causative for tamoxifen resistance. As a consequence of the man
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cbf4a884b7a9cff1a2dbdfd51c2a17e0
https://pubmed.ncbi.nlm.nih.gov/19412734
https://pubmed.ncbi.nlm.nih.gov/19412734