Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Aren, Boulet"'
Autor:
Riley Plett, Paul Mellor, Stephanie Kendall, S. Austin Hammond, Aren Boulet, Kristine Plaza, Frederick S. Vizeacoumar, Franco J. Vizeacoumar, Deborah H. Anderson
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-16 (2022)
Abstract The lack of targeted therapies for triple-negative breast cancer (TNBC) contributes to their high mortality rates and high risk of relapse compared to other subtypes of breast cancer. Most TNBCs (75%) have downregulated the expression of CRE
Externí odkaz:
https://doaj.org/article/186e1e23d6a14840ad9f12c034534a4f
Autor:
Kimberly A. Jett, Zakery N. Baker, Amzad Hossain, Aren Boulet, Paul A. Cobine, Sagnika Ghosh, Philip Ng, Orhan Yilmaz, Kris Barreto, John DeCoteau, Karen Mochoruk, George N. Ioannou, Christopher Savard, Sai Yuan, Osama H.M.H. Abdalla, Christopher Lowden, Byung-Eun Kim, Hai-Ying Mary Cheng, Brendan J. Battersby, Vishal M. Gohil, Scot C. Leary
Publikováno v:
The Journal of Clinical Investigation, Vol 133, Iss 1 (2023)
Signaling circuits crucial to systemic physiology are widespread, yet uncovering their molecular underpinnings remains a barrier to understanding the etiology of many metabolic disorders. Here, we identified a copper-linked signaling circuit activate
Externí odkaz:
https://doaj.org/article/018c1e9c28eb4a92a02a5abcb7afd106
Autor:
Christopher Lowden, Aren Boulet, Nicholas A. Boehler, Shavanie Seecharran, Julian Rios Garcia, Nicholas J. Lowe, Jiashu Liu, Jonathan L.K. Ong, Wanzhang Wang, Lingfeng Ma, Arthur H. Cheng, Adriano Senatore, D. Ashley Monks, Bao-hua Liu, Scot C. Leary, Hai-Ying Mary Cheng
Publikováno v:
Cell Reports, Vol 36, Iss 11, Pp 109704- (2021)
Summary: Histone variants are crucial regulators of chromatin structure and gene transcription, yet their functions within the brain remain largely unexplored. Here, we show that the H2A histone variant H2A.Z is essential for neuronal survival. Mice
Externí odkaz:
https://doaj.org/article/9ddb9e63dbef4337b6ecf22bdd986877
Autor:
Xinyu Zhu, Aren Boulet, Katherine M Buckley, Casey B Phillips, Micah G Gammon, Laura E Oldfather, Stanley A Moore, Scot C Leary, Paul A Cobine
Publikováno v:
eLife, Vol 10 (2021)
The mitochondrial carrier family protein SLC25A3 transports both copper and phosphate in mammals, yet in Saccharomyces cerevisiae the transport of these substrates is partitioned across two paralogs: PIC2 and MIR1. To understand the ancestral state o
Externí odkaz:
https://doaj.org/article/d7782b206ce2471e920d657626b83899
Autor:
Shivatheja Soma, Marcos N. Morgada, Mandar T. Naik, Aren Boulet, Anna A. Roesler, Nathaniel Dziuba, Alok Ghosh, Qinhong Yu, Paul A. Lindahl, James B. Ames, Scot C. Leary, Alejandro J. Vila, Vishal M. Gohil
Publikováno v:
Cell Reports, Vol 29, Iss 12, Pp 4114-4126.e5 (2019)
Summary: In eukaryotes, cellular respiration is driven by mitochondrial cytochrome c oxidase (CcO), an enzyme complex that requires copper cofactors for its catalytic activity. Insertion of copper into its catalytically active subunits, including COX
Externí odkaz:
https://doaj.org/article/6322aed5c16a4dc79ccf348a0f9dc969
Autor:
Christopher J. Hlynialuk, Binbing Ling, Zakery N. Baker, Paul A. Cobine, Lisa D. Yu, Aren Boulet, Timothy Wai, Amzad Hossain, Amr M. El Zawily, Pamela J. McFie, Scot J. Stone, Francisca Diaz, Carlos T. Moraes, Deepa Viswanathan, Michael J. Petris, Scot C. Leary
Publikováno v:
Cell Reports, Vol 10, Iss 6, Pp 933-943 (2015)
Human SCO1 fulfills essential roles in cytochrome c oxidase (COX) assembly and the regulation of copper (Cu) homeostasis, yet it remains unclear why pathogenic mutations in this gene cause such clinically heterogeneous forms of disease. Here, we esta
Externí odkaz:
https://doaj.org/article/0340b7e99d004b629b58872104cbc6a2
Autor:
Nicholas A. Boehler, Shavanie Seecharran, Aren Boulet, Jiashu Liu, Scot C. Leary, Hai-Ying M. Cheng, Lingfeng Ma, Nicholas J. Lowe, D. Ashley Monks, Wanzhang Wang, Bao-hua Liu, Arthur H. Cheng, Adriano Senatore, Julian Rios Garcia, Jonathan L.K. Ong, Christopher Lowden
Publikováno v:
Cell Reports, Vol 36, Iss 11, Pp 109704-(2021)
Summary: Histone variants are crucial regulators of chromatin structure and gene transcription, yet their functions within the brain remain largely unexplored. Here, we show that the H2A histone variant H2A.Z is essential for neuronal survival. Mice
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::30b2c86be51e7ba871d149510bbb16e4
http://www.sciencedirect.com/science/article/pii/S2211124721011517
http://www.sciencedirect.com/science/article/pii/S2211124721011517
Autor:
Mochoruk K, Zakery N. Baker, Savard C, Aren Boulet, DeCoteau J, Christopher Lowden, Brendan J. Battersby, Scot C. Leary, Harry Cheng, Yuan S, Kimberly A. Jett, Ahmed Hossain, Ioannou G, Paul A. Cobine, Yilmaz O, Souparno Ghosh, Ng P, Brian N. Kim, Gohil Vmm, Barretto K
Signaling circuits crucial to systemic physiology are widespread, yet uncovering their molecular underpinnings remains a barrier to understanding the etiology of many metabolic disorders. Here, we identify a copper-linked signaling circuit activated
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e6cac4191b68fca6c0ca73424ae06f72
https://doi.org/10.1101/2021.07.02.450924
https://doi.org/10.1101/2021.07.02.450924
Autor:
Aren Boulet, Paul A. Cobine, Scot C. Leary, Casey B. Phillips, Laura E Oldfather, Micah G. Gammon, Xinyu Zhu, Stanley A. Moore, Katherine M. Buckley
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ffe1900454f8d56ef5a720aeaf0b8b88
https://doi.org/10.7554/elife.64690.sa2
https://doi.org/10.7554/elife.64690.sa2
Autor:
Micah G. Gammon, Xinyu Zhu, Laura E Oldfather, Casey B. Phillips, Stanley A. Moore, Paul A. Cobine, Katherine M. Buckley, Aren Boulet, Scot C. Leary
Publikováno v:
eLife
eLife, Vol 10 (2021)
eLife, Vol 10 (2021)
Mitochondrial carrier family (MCF/SLC25) proteins are selective transporters that maintain the mitochondrial metabolome. Here we combine computational, biochemical and phenotypic approaches to understand substrate selectivity of SLC25A3. In mammals,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::338d34de9393b6e32d5a14a6cf3ac82c
https://doi.org/10.1101/2020.11.02.365692
https://doi.org/10.1101/2020.11.02.365692