Zobrazeno 1 - 10
of 22
pro vyhledávání: '"Areetha, D'Souza"'
Autor:
Areetha D’Souza, Liam R. Marshall, Jennifer Yoon, Alona Kulesha, Dona I. U. Edirisinghe, Siddarth Chandrasekaran, Parth Rathee, Rajeev Prabhakar, Olga V. Makhlynets
Publikováno v:
Nano Convergence, Vol 9, Iss 1, Pp 1-8 (2022)
Abstract We have rationally designed a peptide that assembles into a redox-responsive, antimicrobial metallohydrogel. The resulting self-healing material can be rapidly reduced by ascorbate under physiological conditions and demonstrates a remarkable
Externí odkaz:
https://doaj.org/article/84ba9b91efee4c9ab5c98ea3ba16ac76
Autor:
Dona Imanga Upamadi Edirisinghe, Areetha D’Souza, Maryam Ramezani, Robert J. Carroll, Quenten Chicón, Cheyene L. Muenzel, Jonathan Soule, Mary Beth Browning Monroe, Alison E. Patteson, Olga V. Makhlynets
Publikováno v:
Molecules, Vol 28, Iss 11, p 4390 (2023)
A short peptide, FHHF-11, was designed to change stiffness as a function of pH due to changing degree of protonation of histidines. As pH changes in the physiologically relevant range, G′ was measured at 0 Pa (pH 6) and 50,000 Pa (pH 8). This pepti
Externí odkaz:
https://doaj.org/article/34572ecdcd804feb88d3c4e73b0fcff0
Autor:
Sagar Bhattacharya, Eleonora G. Margheritis, Katsuya Takahashi, Alona Kulesha, Areetha D’Souza, Inhye Kim, Jennifer H. Yoon, Jeremy R. H. Tame, Alexander N. Volkov, Olga V. Makhlynets, Ivan V. Korendovych
Publikováno v:
Nature. 610:389-393
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::98588a0007ab554fdeed90e7d7e8f449
https://doi.org/10.1038/s41586-022-05278-9
https://doi.org/10.1038/s41586-022-05278-9
Publikováno v:
Biochem Soc Trans
Nucleotide excision repair (NER) is a versatile DNA repair pathway essential for the removal of a broad spectrum of structurally diverse DNA lesions arising from a variety of sources, including UV irradiation and environmental toxins. Although the co
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b7e1d784a91d3e19d1d02cb4aeefef5f
https://doi.org/10.1042/bst20210246
https://doi.org/10.1042/bst20210246
Autor:
Mihyun Kim, Hyun-Suk Kim, Areetha D’Souza, Kaitlyn Gallagher, Eunwoo Jeong, Agnieszka Topolska-Woś, Kateryna Ogorodnik Le Meur, Chi-Lin Tsai, Miaw-Sheue Tsai, Minyong Kee, John A. Tainer, Jung-Eun Yeo, Walter J. Chazin, Orlando D. Schärer
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America. 119(34)
The xeroderma pigmentosum protein A (XPA) and replication protein A (RPA) proteins fulfill essential roles in the assembly of the preincision complex in the nucleotide excision repair (NER) pathway. We have previously characterized the two interactio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3e7f5d1d0b7113d6588abb317faebf8a
https://pubmed.ncbi.nlm.nih.gov/35969784
https://pubmed.ncbi.nlm.nih.gov/35969784
Autor:
Surajit Bhattacharjya, Areetha D'Souza
Publikováno v:
Biochemistry. 60:431-439
The field of de novo protein design has met with considerable success over the past few decades. Heme, a cofactor has often been introduced to impart a diverse array of functions to a protein, ranging from electron transport to respiration. In nature
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b79f1b7c64574224333c6c94d8ccd943
https://doi.org/10.1021/acs.biochem.0c00662
https://doi.org/10.1021/acs.biochem.0c00662
Autor:
Sagar Bhattacharya, Eleanor Margheritis, Areetha D'Souza, Nico Nuland, Jeremy Tame, Alexander Volkov, Olga Makhlynets, Ivan Korendovych
Publikováno v:
The FASEB Journal. 36
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ad5219b0fea75583f6fe3cc54f3d2433
https://doi.org/10.1096/fasebj.2022.36.s1.00r28
https://doi.org/10.1096/fasebj.2022.36.s1.00r28
Autor:
Mary Beth B. Monroe, Kelly M. Schultz, Olga V. Makhlynets, Zsofia Lengyel-Zhand, Matthew D. Wehrman, Areetha D'Souza, Alex Sternisha, Liam R. Marshall, Pallavi M. Gosavi, Jennifer H. Yoon, Garrick Centola, Henry T. Beaman
Publikováno v:
ACS Applied Materials & Interfaces. 12:17091-17099
Silver compounds have been used extensively for wound healing because of their antimicrobial properties, but high concentrations of silver are toxic to mammalian cells. We designed a peptide that binds silver and releases only small amounts of this i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5cffc8b2a3774191bce25330733394c7
https://doi.org/10.1021/acsami.0c01154
https://doi.org/10.1021/acsami.0c01154
Autor:
Areetha D’Souza, Liam R. Marshall, Jennifer Yoon, Alona Kulesha, Dona I. U. Edirisinghe, Siddarth Chandrasekaran, Parth Rathee, Rajeev Prabhakar, Olga V. Makhlynets
Publikováno v:
Nano convergence. 9(1)
We have rationally designed a peptide that assembles into a redox-responsive, antimicrobial metallohydrogel. The resulting self-healing material can be rapidly reduced by ascorbate under physiological conditions and demonstrates a remarkable 160-fold
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7ffe018e2b9d64e93e3986e4d0d27513
https://pubmed.ncbi.nlm.nih.gov/35478076
https://pubmed.ncbi.nlm.nih.gov/35478076
Autor:
Ivan Korendovych, Sagar Bhattacharya, Eleanora Margheritis, Katsuya Takahashi, Alona Kulesha, Areetha D'Souza, Inhye Kim, Jeremy Tame, Jennifer Yoon, Alexander Volkov, Olga Makhlynets
Directed evolution can rapidly achieve dramatic improvements in the properties of a protein or bestow entirely new functions on it. We have discovered a strong correlation between the probability of finding a productive mutation at a particular posit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a4950de2418c8971d5aa72a2bcb8bd96
https://doi.org/10.21203/rs.3.rs-1150236/v1
https://doi.org/10.21203/rs.3.rs-1150236/v1
