Zobrazeno 1 - 10
of 42
pro vyhledávání: '"Ardith W. El-Kareh"'
Publikováno v:
Journal of Theoretical Biology. 569:111533
A mathematical model for the mammalian cell cycle is developed as a system of 13 coupled nonlinear ordinary differential equations. The variables and interactions included in the model are based on detailed consideration of available experimental dat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b9d6b2469ea0b95db67a030f10d43211
https://doi.org/10.1016/j.jtbi.2023.111533
https://doi.org/10.1016/j.jtbi.2023.111533
Autor:
Ardith W. El-Kareh, Timothy W. Secomb
Publikováno v:
Neoplasia: An International Journal for Oncology Research, Vol 7, Iss 7, Pp 705-713 (2005)
A mathematical model is presented for the cellular uptake and cytotoxicity of the anticancer drug doxorubicin. The model assumes sigmoidal, Hill-type dependence of cell survival on drug-induced damage. Experimental evidence indicates distinct intrace
Externí odkaz:
https://doaj.org/article/c459f83609884ae5b4cae30ccf9defd1
Autor:
Ardith W. El-Kareh, Timothy W. Secomb
Publikováno v:
Neoplasia: An International Journal for Oncology Research, Vol 6, Iss 2, Pp 117-127 (2004)
A theoretical model for the intraperitoneal (i.p.) delivery of cisplatin and heat to tumor metastases in tissues adjacent to the peritoneal cavity is presented. The penetration distance (the depth to which drug diffuses directly from the cavity into
Externí odkaz:
https://doaj.org/article/fa0bddb9ec0d446aad6f9eb3f21ee0fe
Autor:
Ardith W. El-Kareh, Timothy W. Secomb
Publikováno v:
Neoplasia: An International Journal for Oncology Research, Vol 5, Iss 2, Pp 161-169 (2003)
A simple theoretical model for the cellular pharmacodynamics of cisplatin is presented. The model, which takes into account the kinetics of cisplatin uptake by cells and the intracellular binding of the drug, can be used to predict the dependence of
Externí odkaz:
https://doaj.org/article/1a6e1daf09924a87b5db1e2c24b2cdbb
Autor:
Ardith W. El-Kareh, Timothy W. Secomb
Publikováno v:
Neoplasia: An International Journal for Oncology Research, Vol 2, Iss 4, Pp 325-338 (2000)
Determining the optimal mode of delivery for doxorubicin is important given the wide use of the drug against many tumor types. The relative performances of bolus injection, continuous infusion, liposomal and thermoliposomal delivery are not yet defin
Externí odkaz:
https://doaj.org/article/47cecb6a19744b6eaa1365c7873fdcdc
Publikováno v:
Journal of Theoretical Biology. 464:180
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::41d07f9c060a6c2f6aa3fe2b0374b391
https://doi.org/10.1016/j.jtbi.2018.12.041
https://doi.org/10.1016/j.jtbi.2018.12.041
Publikováno v:
Journal of Theoretical Biology. 464:181
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::23add27149f1d4a3209ffd69a659f9f7
https://doi.org/10.1016/j.jtbi.2018.12.040
https://doi.org/10.1016/j.jtbi.2018.12.040
Publikováno v:
Bulletin of mathematical biology. 80(5)
Many cancer patients receive combination treatments with radiation and chemotherapy. Available mathematical models for cellular pharmacodynamics have limited ability to represent observed in vitro responses to radiochemotherapy. Here, a family of add
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0e3acf785a1451c33dd1eec4f1fff05d
https://pubmed.ncbi.nlm.nih.gov/28849417
https://pubmed.ncbi.nlm.nih.gov/28849417
Publikováno v:
Journal of Theoretical Biology. 294:56-73
A mathematical model of the interactions between a growing tumor and the immune system is presented. The equations and parameters of the model are based on experimental and clinical results from published studies. The model includes the primary cell
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::720f1a4602ca46f5f1042a852cbada61
https://doi.org/10.1016/j.jtbi.2011.10.027
https://doi.org/10.1016/j.jtbi.2011.10.027
Publikováno v:
Journal of theoretical biology. 380
Complete clinical regressions of solid tumors in response to chemotherapy are difficult to explain by direct cytotoxicity alone, because of low growth fractions and obstacles to drug delivery. A plausible indirect mechanism that might reconcile this
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ed302479bd42da7046a97bfc609b1501
http://ora.ox.ac.uk/objects/uuid:4fd84e7c-2055-4b94-89c5-2b7f67ddfdc3
http://ora.ox.ac.uk/objects/uuid:4fd84e7c-2055-4b94-89c5-2b7f67ddfdc3