Multiscale Model Identifies Improved Schedule for Treatment of Acute Myeloid Leukemia In Vitro With the Mcl‐1 Inhibitor AZD5991

Autor: Ardeshir Goliaei, Haley A. Woods, Adriana E. Tron, Matthew A. Belmonte, J. Paul Secrist, Douglas Ferguson, Lisa Drew, Adrian J. Fretland, Bree B. Aldridge, Francis D. Gibbons

Publikováno v: CPT: Pharmacometrics & Systems Pharmacology, Vol 9, Iss 10, Pp 561-570 (2020)

Anticancer efficacy is driven not only by dose but also by frequency and duration of treatment. We describe a multiscale model combining cell cycle, cellular heterogeneity of B‐cell lymphoma 2 family proteins, and pharmacology of AZD5991, a potent

Externí odkaz: https://doaj.org/article/07ad18bfe7b84642b234c602cec0a6fa

Multiscale Model Identifies Improved Schedule for Treatment of Acute Myeloid Leukemia In Vitro With the Mcl‐1 Inhibitor AZD5991

Autor: Francis D. Gibbons, Haley Woods, Matthew A. Belmonte, Ardeshir Goliaei, Douglas Ferguson, Adriana E. Tron, Bree B. Aldridge, J. Paul Secrist, Adrian J. Fretland, Lisa Drew

Publikováno v: CPT: Pharmacometrics & Systems Pharmacology, Vol 9, Iss 10, Pp 561-570 (2020)
CPT: Pharmacometrics & Systems Pharmacology

Anticancer efficacy is driven not only by dose but also by frequency and duration of treatment. We describe a multiscale model combining cell cycle, cellular heterogeneity of B-cell lymphoma 2 family proteins, and pharmacology of AZD5991, a potent sm

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2e59c72d486a10dbcaf60a38ec56d943
https://doaj.org/article/07ad18bfe7b84642b234c602cec0a6fa

Subcellular localization of Rap1 GTPase activator CalDAG-GEFI is orchestrated by interaction of its atypical C1 domain with membrane phosphoinositides

Autor: Aaron A. Cook, Ardeshir Goliaei, Lucia Stefanini, Marjorie Poggi, Brenda Temple, Florence Golesi, Wolfgang Bergmeier, Matthias Canault, Muzaddid Sarker, Sharon L. Campbell, Mohammad A. I. Khan

Publikováno v: J Thromb Haemost
Journal of Thrombosis and Haemostasis
Journal of Thrombosis and Haemostasis, 2019, 18 (3), pp.693-705. ⟨10.1111/jth.14687⟩
Journal of Thrombosis and Haemostasis, Wiley, 2019, 18 (3), pp.693-705. ⟨10.1111/jth.14687⟩

International audience; Background The small GTPase Rap1 and its guanine nucleotide exchange factor, CalDAG-GEFI (CDGI), are critical for platelet function and hemostatic plug formation. CDGI function is regulated by a calcium binding EF hand regulat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::173db87d767b36b08860af8d8757e2c1
https://pubmed.ncbi.nlm.nih.gov/31758832

Mechanism of Membrane Poration by Shock Wave Induced Nanobubble Collapse: A Molecular Dynamics Study

Autor: Upendra Adhikari, Max L. Berkowitz, Ardeshir Goliaei

Publikováno v: The Journal of Physical Chemistry B. 119:6225-6234

We performed coarse-grained molecular dynamics simulations in order to understand the mechanism of membrane poration by shock wave induced nanobubble collapse. Pressure profiles obtained from the simulations show that the shock wave initially hits th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::71734e01e432367a38769939f964cc37
https://doi.org/10.1021/acs.jpcb.5b02218

Interaction of Poloxamers with Lipid Bilayer: Molecular Dynamics Simulations using United Atom and Coarse-Grained Force Fields

Autor: Upendra Adhikari, Ardeshir Goliaei, Max L. Berkowitz

Publikováno v: Biophysical Journal. 110(3)

Poloxamers are triblock copolymers containing a hydrophilic polyethylene oxide block on either side of a hydrophobic polypropylene oxide block (PEO-PPO-PEO). Poloxamer molecules of different block lengths are used for various purposes: to facilitate

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::00192c89e4cf57615ff5c88c91fdaee5