Výsledky vyhledávání - "Arda B. Celen"

Sumoylation on its 25th anniversary: mechanisms, pathology, and emerging concepts

Autor: Umut Sahin, Arda B. Celen

Publikováno v: The FEBS Journal. 287:3110-3140

Sumoylation is an essential post-translational modification intimately involved in a diverse range of eukaryotic cellular mechanisms. Small ubiquitin-like modifier (SUMO) protein isoforms can be reversibly linked to lysine residues that reside within

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a661f56cfec188cd6232265c7587b946
https://doi.org/10.1111/febs.15319

Zobrazit plný text záznamu

Plný text ve formátu HTML

A cohort study to determine factors associated with upstaging cutaneous squamous cell carcinoma during Mohs surgery

Autor: Theresa N. Canavan, Arda B. Celen, Nicholas J. Frazzette, John A. Carucci, Nicole Doudican, Mary L. Stevenson

Publikováno v: Journal of the American Academy of Dermatology. 88(1)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c37f34fc5c03ccbdcbdef4bfcb439110
https://pubmed.ncbi.nlm.nih.gov/35378171

Zobrazit plný text záznamu

Sumoylation of Cas9 at lysine 848 regulates protein stability and DNA binding

Autor: Tunahan Ergünay, Özgecan Ayhan, Arda B Celen, Panagiota Georgiadou, Emre Pekbilir, Yusuf T Abaci, Duygu Yesildag, Mandy Rettel, Ulduz Sobhiafshar, Anna Ogmen, NC Tolga Emre, Umut Sahin

Publikováno v: Life Science Alliance

Cas9 is sumoylated and ubiquitylated in human cells. K848 is the major SUMO2/3 modification site, but multiple lysines are ubiquitylated, precipitating proteasomal degradation. Preventing Cas9 sumoylation by K848 ablation or by pharmacologic means re

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::21719ae127bd87ee5aec82d13f6fa3e8
https://doi.org/10.26508/lsa.202101078

Zobrazit plný text záznamu

Analysis of the Conditions That Affect the Selective Processing of Endogenous Notch1 by ADAM10 and ADAM17

Autor: Arda B. Celen, Thorsten Maretzky, Rolake O. Alabi, Jose Lora, Carl P. Blobel

Publikováno v: International Journal of Molecular Sciences
Volume 22
Issue 4
International Journal of Molecular Sciences, Vol 22, Iss 1846, p 1846 (2021)

Notch signaling is critical for controlling a variety of cell fate decisions during metazoan development and homeostasis. This unique, highly conserved signaling pathway relies on cell-to-cell contact, which triggers the proteolytic release of the cy

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::debd3c7ece8adf9562c1d21e399a8fc8
https://doi.org/10.3390/ijms22041846

Zobrazit plný text záznamu

Loss of odor-induced c-Fos expression of juxtaglomerular activity following maintenance of mice on fatty diets

Autor: Nicolas Thiebaud, Debra Ann Fadool, Erminia Fardone, Melissa L. Cooper, Nicholas A Schreiter, Arda B Celen

Publikováno v: Journal of bioenergetics and biomembranes. 51(1)

Diet-induced obesity (DIO) decreases the number of OMP+ olfactory sensory neurons (OSN) in the olfactory epithelium by 25% and reduces correlate axonal projections to the olfactory bulb (OB). Whether surviving OSNs have equivalent odor responsivity i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9c799fb1552397a480ab6ddc12977e8a
https://pubmed.ncbi.nlm.nih.gov/30203289

Zobrazit plný text záznamu