Single nucleotide polymorphism in gene encoding transcription factor Prep1 is associated with HIV-1-associated dementia.

Autor: Sebastiaan M Bol, Thijs Booiman, Daniëlle van Manen, Evelien M Bunnik, Ard I van Sighem, Margit Sieberer, Brigitte Boeser-Nunnink, Frank de Wolf, Hanneke Schuitemaker, Peter Portegies, Neeltje A Kootstra, Angélique B van 't Wout

Publikováno v: PLoS ONE, Vol 7, Iss 2, p e30990 (2012)

BACKGROUND: Infection with HIV-1 may result in severe cognitive and motor impairment, referred to as HIV-1-associated dementia (HAD). While its prevalence has dropped significantly in the era of combination antiretroviral therapy, milder neurocogniti

Externí odkaz: https://doaj.org/article/39162ba0da244103989f1c69d89be247

2018 update to the HIV-TRePS system: the development of new computational models to predict HIV treatment outcomes, with or without a genotype, with enhanced usability for low-income settings

Autor: Luminita Ene, Shanmugam Saravanan, Andrew D. Revell, E Schuelter, Julio S. G. Montaner, Catherine A Rehm, Brian K. Agan, Peter Reiss, Tobias F. Rinke de Wit, Robin Wood, Maurizio Zazzi, David A. Cooper, Elisa de Lazzari, Carina Cesar, Ricardo Sobhie Diaz, Brendan Larder, Gerardo Alvarez-Uria, Rdi Data, Scott Wegner, J A Metcalf, Gordana Dragovic, H. Clifford Lane, Carlo Torti, Roos Barth, Gaston Picchio, Dechao Wang, Omar Sued, Richard Harrigan, Stefano Vella, John D. Baxter, Richard Norris, Marie-Pierre deBethune, Ard I van Sighem, Lidia Ruiz, Julio Montaner, Anton Pozniak, Schlomo Staszewski, Brian Gazzard, Bonaventura Clotet, Sundhiya Mandalia, Juan Sierra Madero, Bonventura Clotet, Lotty Ledwaba, Cliff Lane, Wataru Sugiura, Adrian Streinu-Cercel, Andrew Carr, Kim C. E. Sigaloff, José M. Gatell, Dolphina Cogill, Hugo Tempelman, Karl Hesse, Vincent C. Marconi, Raph L Hamers, Colette Smith, Rolf Kaiser, Gabrielle Dettorre, Carl Morrow, Pachamuthu Balavskrishnan, Tulio de Oliveira, Sean Emery, Cecilia Sucupira, Laura Monno, Emanuel Vlahakis, Raph L. Hamers, Paul Khabo, Chris Hoffmann, Ard van Sighem, Mark T. Nelson, Maria-Jesus Perez-Elias

Publikováno v: Journal of antimicrobial chemotherapy, 73(8), 2186-2196. Oxford University Press

Objectives Optimizing antiretroviral drug combination on an individual basis can be challenging, particularly in settings with limited access to drugs and genotypic resistance testing. Here we describe our latest computational models to predict treat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bb0b2b20ef76c760d2eb547fed68117d
https://pubmed.ncbi.nlm.nih.gov/29889249

An update to the HIV-TRePS system: The development of new computational models that do not require a genotype to predict HIV treatment outcomes

Autor: Dechao Wang, Julio S. G. Montaner, Marie-Pierre deBethune, Gerardo Alvarez-Uria, Annemarie M. J. Wensing, Emanuel Vlahakis, Raph L. Hamers, John D. Baxter, Bonventura Clotet, Elisa de Lazzari, Kim C. E. Sigaloff, Sean Emery, Gaston Picchio, Richard Norris, Vincent Marconi, Roos Barth, Gordana Dragovic, Bonaventura Clotet, Brian Gazzard, Ard van Sighem, Luminita Ene, Andrew D. Revell, Laura Monno, Andrew Carr, Richard Harrigan, David A. Cooper, Mark Nelson, Scott Wegner, H. Clifford Lane, Sundhiya Mandalia, Ard I van Sighem, Maurizio Zazzi, Carlo Torti, Anton Pozniak, Adrian Streinu-Cercel, Wataru Sugiura, Carl A. Morrow, Tobias F. Rinke de Wit, Brendan Larder, Maria-Jesus Perez-Elias, J A Metcalf, Schlomo Staszewski, Karl Hesse, Cliff Lane, José M. Gatell, Julio Montaner, Peter Reiss, Robin Wood, Hugo Tempelman, Lidia Ruiz, Brian K. Agan

Publikováno v: Journal of Antimicrobial Chemotherapy, 69(4):dkt447, 1104-1110. Oxford University Press
Journal of antimicrobial chemotherapy, 69(4), 1104-1110. Oxford University Press
Revell, A D, Wang, D, Wood, R, Morrow, C, Tempelman, H, Hamers, R, Alvarez-Uria, G, Streinu-Cercel, A, Ene, L, Wensing, A, Reiss, P, Van Sighem, A I, Nelson, M, Emery, S, Montaner, J S G, Lane, H C, Larder, B A, Van sighem, A, Harrigan, R, Rinke de Wit, T, Sigaloff, K, Agan, B, Marconi, V, Wegner, S, Sugiura, W, Zazzi, M, Gatell, J, Lazzari, E, Gazzard, B, Pozniak, A, Mandalia, S, Ruiz, L, Clotet, B, Staszewski, S, Torti, C, Metcalf, J, Perez-Elias, M J, Carr, A, Norris, R, Hesse, K, Vlahakis, E, Barth, R & Dragovic, G 2014, ' An update to the HIV-TRePS system : The development of new computational models that do not require a genotype to predict HIV treatment outcomes ', Journal of Antimicrobial Chemotherapy, vol. 69, no. 4, dkt447, pp. 1104-1110 . https://doi.org/10.1093/jac/dkt447

Objectives: The optimal individualized selection of antiretroviral drugs in resource-limited settings is challenging because of the limited availability of drugs and genotyping. Here we describe the development of the latest computational models to p

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d91a0ce8c798536dc6a6066574fc956e
https://research.vumc.nl/en/publications/bc40283e-8545-4ae3-9f12-61ed7acc2c4a

Mortality and progression to AIDS after starting highly active antiretroviral therapy.

Autor: Ard I. van Sighem

Publikováno v: AIDS (02699370); Oct2003, Vol. 17 Issue 15, p2227-2236, 10p