Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Archna P. Gupta"'
Autor:
Archna P Gupta, Wai Hoe Chin, Lei Zhu, Sachel Mok, Yen-Hoon Luah, Eng-How Lim, Zbynek Bozdech
Publikováno v:
PLoS Pathogens, Vol 9, Iss 2, p e1003170 (2013)
Epigenetic mechanisms are emerging as one of the major factors of the dynamics of gene expression in the human malaria parasite, Plasmodium falciparum. To elucidate the role of chromatin remodeling in transcriptional regulation associated with the pr
Externí odkaz:
https://doaj.org/article/2cd8ecd45a444de39399d9629ae1cbe6
Autor:
Katherine T Andrews, Archna P Gupta, Thanh N Tran, David P Fairlie, Geoffrey N Gobert, Zbynek Bozdech
Publikováno v:
PLoS ONE, Vol 7, Iss 2, p e31847 (2012)
Histone deacetylase (HDAC) inhibitors are being intensively pursued as potential new drugs for a range of diseases, including malaria. HDAC inhibitors are also important tools for the study of epigenetic mechanisms, transcriptional control, and other
Externí odkaz:
https://doaj.org/article/2662f5cb0f714304aad887d85ebc595f
Publikováno v:
PLoS Pathogens, Vol 6, Iss 1, p e1000737 (2010)
The apparent paucity of molecular factors of transcriptional control in the genomes of Plasmodium parasites raises many questions about the mechanisms of life cycle regulation in these malaria parasites. Epigenetic regulation has been suggested to pl
Externí odkaz:
https://doaj.org/article/6e166e6a8c874d2982e1be06ba9b53b9
Autor:
Paul R. Gilson, Michael F. Duffy, Gernot Längst, Danny W. Wilson, Michaela Petter, Shu Wei Lim, Paul Jenoe, Archna P. Gupta, Zbynek Bozdech, Sophie Clara Oehring, Graham Brown, Gabrielle A. Josling, Till S. Voss, Suzette Moes, Olivier Dietz, Thomas Schubert, Brendan S. Crabb
Publikováno v:
Cell host & microbe
SummaryDuring red-blood-cell-stage infection of Plasmodium falciparum, the parasite undergoes repeated rounds of replication, egress, and invasion. Erythrocyte invasion involves specific interactions between host cell receptors and parasite ligands a
Autor:
Michaela Petter, Archna P. Gupta, Graham Brown, Chin Chin Lee, Michael F. Duffy, Zbynek Bozdech, Shamista A. Selvarajah, Wai Hoe Chin
Publikováno v:
Molecular Microbiology. 87:1167-1182
Summary Histone variants are important components of eukaryotic chromatin and can alter chromatin structure to confer specialized functions. H2B variant histones are rare in nature but have evolved independently in the phyla Apicomplexa and Trypanaso
Publikováno v:
Molecular Microbiology. 86:1345-1363
Fatty acids stored as triglycerides, an important source of cellular energy, are catabolized through β-oxidation pathways predicted to occur both in peroxisomes and mitochondria in filamentous fungi. Here, we characterize the function of Enoyl-CoA h
Autor:
Peter R. Preiser, Evarist Planet, Llús Ribas de Pouplana, Alfred Cortés, Archna P. Gupta, Zbynek Bozdech, Sachel Mok, Núria Rovira-Graells, Valerie M. Crowley
Publikováno v:
Genome Research
Genome Research; Vol 22
Genome Research; Vol 22
Malaria genetic variation has been extensively characterized, but the level of epigenetic plasticity remains largely unexplored. Here we provide a comprehensive characterization of transcriptional variation in the most lethal malaria parasite, Plasmo
Autor:
Zbynek Bozdech, Archna P. Gupta, Wai Hoe Chin, Eng-How Lim, Lei Zhu, Sachel Mok, Yen-Hoon Luah
Publikováno v:
PLoS Pathogens, Vol 9, Iss 2, p e1003170 (2013)
PLoS Pathogens
PLoS Pathogens
Epigenetic mechanisms are emerging as one of the major factors of the dynamics of gene expression in the human malaria parasite, Plasmodium falciparum. To elucidate the role of chromatin remodeling in transcriptional regulation associated with the pr
Publikováno v:
Molecular microbiology. 86(6)
Fatty acids stored as triglycerides, an important source of cellular energy, are catabolized through β-oxidation pathways predicted to occur both in peroxisomes and mitochondria in filamentous fungi. Here, we characterize the function of Enoyl-CoA h
Publikováno v:
Methods in molecular biology (Clifton, N.J.). 923
DNA microarray is presently one of the most powerful and fastest growing technologies for genomic research of infectious diseases. Accordingly, DNA microarray-based global analyses of Plasmodium parasites provided many insights into the general biolo