Crucial Players for Inter-Organelle Communication: PI5P4Ks and Their Lipid Product PI-4,5-P2 Come to the Surface

Autor: Archna Ravi, Lavinia Palamiuc, Brooke M. Emerling

Publikováno v: Frontiers in Cell and Developmental Biology, Vol 9 (2022)

While organelles are individual compartments with specialized functions, it is becoming clear that organellar communication is essential for maintaining cellular homeostasis. This cooperation is carried out by various interactions taking place on the

Externí odkaz: https://doaj.org/article/202713ba9c994f08ad4a00da2ac920a2

Crucial Players for Inter-Organelle Communication: PI5P4Ks and Their Lipid Product PI-4,5-P

Autor: Archna, Ravi, Lavinia, Palamiuc, Brooke M, Emerling

Publikováno v: Frontiers in Cell and Developmental Biology

While organelles are individual compartments with specialized functions, it is becoming clear that organellar communication is essential for maintaining cellular homeostasis. This cooperation is carried out by various interactions taking place on the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::20d7e26e58beedad4ff08b70143b744b
https://pubmed.ncbi.nlm.nih.gov/35071233

PTEN Deficiency and AMPK Activation Promote Nutrient Scavenging and Anabolism in Prostate Cancer Cells

Autor: Seong M. Kim, Pierre Thibault, Brendan T. Finicle, Dong Gao, Michelle A. Digman, Leonel Malacrida, Jue Hou, Aimee L. Edinger, Vaishali Jayashankar, Jane Robertson, Jonathan Chernoff, Bruce J. Tromberg, Archna Ravi, Peter Kubiniok, Eric O. Potma, Tricia T. Nguyen

Publikováno v: Cancer discovery, vol 8, iss 7

We report that PTEN-deficient prostate cancer cells use macropinocytosis to survive and proliferate under nutrient stress. PTEN loss increased macropinocytosis only in the context of AMPK activation, revealing a general requirement for AMPK in macrop

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::45b63fced40a8d3fb79ce4603c6f7559
https://doi.org/10.1158/2159-8290.cd-17-1215

Targeting cancer metabolism by simultaneously disrupting parallel nutrient access pathways

Autor: Bruce J. Tromberg, Seong M. Kim, Robert Edwards, Stephen Hanessian, Ryan J. McMonigle, Garret Guenther, Aimee L. Edinger, Tricia T. Nguyen, Eric O. Potma, Brendan T. Finicle, Yanling Zhang, Bin Chen, Tiffany M. Nguyen, Jue Hou, Atsuo T. Sasaki, Archna Ravi, Satoshi Kofuji, Mari Kono, Lois S. Weisman, Alison N. McCracken, Saurabh G. Roy, Manuel U. Ramirez, Timothy Wiher, Elizabeth Selwan

Publikováno v: Kim, Seong M; Roy, Saurabh G; Chen, Bin; Nguyen, Tiffany M; McMonigle, Ryan J; McCracken, Alison N; et al.(2016). Targeting cancer metabolism by simultaneously disrupting parallel nutrient access pathways. Journal of Clinical Investigation, 126(11), 4088-4102. doi: 10.1172/jci87148. UC Irvine: Institute for Clinical and Translational Science. Retrieved from: http://www.escholarship.org/uc/item/6zh0q267

Oncogenic mutations drive anabolic metabolism, creating a dependency on nutrient influx through transporters, receptors, and macropinocytosis. While sphingolipids suppress tumor growth by downregulating nutrient transporters, macropinocytosis and aut

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3dd0ed68029bf8a65f6d0ff97e053648
https://doi.org/10.1172/jci87148

Concerted modulation of paxillin dynamics at focal adhesions by deleted in liver cancer-1 and focal adhesion kinase during early cell spreading

Autor: Boon Chuan Low, Feroz M. Hameed, Shelly Kaushik, Archna Ravi

Publikováno v: Cytoskeleton. 71:677-694

Deleted in Liver Cancer-1 (DLC1) is a RhoGTPase-activating protein (GAP) and a tumor suppressor often downregulated in cancers. It is localized to the focal adhesions (FAs) and its absence leads to enhanced cell migration, invasion, and metastasis. A

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::e15613ea278c382f3e965d315d0f82e0
https://doi.org/10.1002/cm.21201