Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Archie C. Reyes"'
Autor:
Michael H. J. Rhodin, Archie C. Reyes, Anand Balakrishnan, Nalini Bisht, Nicole M. Kelly, Joyce Sweeney Gibbons, Jonathan Lloyd, Michael Vaine, Tessa Cressey, Miranda Crepeau, Ruichao Shen, Nathan Manalo, Jonathan Castillo, Rachel E. Levene, Daniel Leonard, Tianzhu Zang, Lijuan Jiang, Kellye Daniels, Robert M. Cox, Carolin M. Lieber, Josef D. Wolf, Richard K. Plemper, Sarah R. Leist, Trevor Scobey, Ralph S. Baric, Guoqiang Wang, Bryan Goodwin, Yat Sun Or
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-12 (2024)
Abstract The COVID-19 pandemic has led to the deaths of millions of people and severe global economic impacts. Small molecule therapeutics have played an important role in the fight against SARS-CoV-2, the virus responsible for COVID-19, but their ef
Externí odkaz:
https://doaj.org/article/b18ce07e716a43029667919f23fb41e5
Autor:
Gordon J. Lockbaum, Archie C. Reyes, Jeong Min Lee, Ronak Tilvawala, Ellen A. Nalivaika, Akbar Ali, Nese Kurt Yilmaz, Paul R. Thompson, Celia A. Schiffer
Publikováno v:
Viruses, Vol 13, Iss 2, p 174 (2021)
Viral proteases are critical enzymes for the maturation of many human pathogenic viruses and thus are key targets for direct acting antivirals (DAAs). The current viral pandemic caused by SARS-CoV-2 is in dire need of DAAs. The Main protease (Mpro) i
Externí odkaz:
https://doaj.org/article/5f63463719c241c3bb92df5389254837
Autor:
Santanu Mondal, Yongzhi Chen, Gordon J. Lockbaum, Sudeshna Sen, Sauradip Chaudhuri, Archie C. Reyes, Jeong Min Lee, Arshia N. Kaur, Nadia Sultana, Michael D. Cameron, Scott A. Shaffer, Celia A. Schiffer, Katherine A. Fitzgerald, Paul R. Thompson
Publikováno v:
Journal of the American Chemical Society. 144:21035-21045
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::beb1c6bfa827747f832a9fe06d47bedf
https://doi.org/10.1021/jacs.2c04626
https://doi.org/10.1021/jacs.2c04626
Autor:
Manuel Roqueta-Rivera, Mary Chau, Kelsey Garlick, Anand Balakrishnan, Archie C. Reyes, Jonathan Lloyd, Sourav Ghorai, Jiang Long, Joe Panarese, Bin Wang, Khanh Hoang, Tim Greizer, Lijuan Jiang, Guoqiang Wang, Yat Sun Or, Bryan Goodwin
Publikováno v:
Journal of Hepatology. 77:S745-S746
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9faece611d9bd7593ddbef6685cbda8f
https://doi.org/10.1016/s0168-8278(22)01811-6
https://doi.org/10.1016/s0168-8278(22)01811-6
Publikováno v:
Biochemistry
The role of a global, substrate-driven, enzyme conformational change in enabling the extraordinarily large rate acceleration for orotidine 5’-monophosphate decarboxylase (OMPDC)-catalyzed decarboxylation of orotidine 5’-monophosphate (OMP) is exa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a3ccd85fcac5b1f3fc0dd2c6ea87f1c5
https://pubmed.ncbi.nlm.nih.gov/34726391
https://pubmed.ncbi.nlm.nih.gov/34726391
Autor:
Ellen A. Nalivaika, Gordon J. Lockbaum, Nese Kurt Yilmaz, Paul R. Thompson, Ronak Tilvawala, Akbar Ali, Jeong Min Lee, Celia A. Schiffer, Archie C. Reyes
Publikováno v:
Viruses
Viruses, Vol 13, Iss 174, p 174 (2021)
Volume 13
Issue 2
Viruses, Vol 13, Iss 174, p 174 (2021)
Volume 13
Issue 2
Viral proteases are critical enzymes for the maturation of many human pathogenic viruses and thus are key targets for direct acting antivirals (DAAs). The current viral pandemic caused by SARS-CoV-2 is in dire need of DAAs. The Main protease (Mpro) i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e5d93e5f46878910aaa848b1632b83e4
http://europepmc.org/articles/PMC7911568
http://europepmc.org/articles/PMC7911568
Publikováno v:
Biochemistry
A comparison of the values of kcat/Km for reduction of dihydroxyacetone phosphate (DHAP) by NADH catalyzed by wild type and K120A/R269A variant glycerol-3-phosphate dehydrogenase from human liver (hlGPDH) shows that the transition state for enzyme-ca
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c6e640b67b7f3f042933bb237966b3d7
https://pubmed.ncbi.nlm.nih.gov/32250105
https://pubmed.ncbi.nlm.nih.gov/32250105
Autor:
John A. Gerlt, Astrid P. Koudelka, David C. Plache, John P. Richard, Tina L. Amyes, Archie C. Reyes
Publikováno v:
Journal of the American Chemical Society
We report the results of a study of the catalytic role of a network of four interacting amino acid side chains at yeast orotidine 5′-monophosphate decarboxylase (ScOMPDC), by the stepwise replacement of all four side chains. The H-bond, which links
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::363d9ef17a0581a5e7825d2b1f8e56c2
https://doi.org/10.1021/jacs.8b09609
https://doi.org/10.1021/jacs.8b09609
Publikováno v:
Accounts of Chemical Research
Conspectus The mystery associated with catalysis by what were once regarded as protein black boxes, diminished with the X-ray crystallographic determination of the three-dimensional structures of enzyme–substrate complexes. The report that several
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6ac3f85bcf7fd5ee0d0efa49927f0e30
https://doi.org/10.1021/acs.accounts.8b00059
https://doi.org/10.1021/acs.accounts.8b00059
Autor:
Venkatesh V. Nemmara, Sarah Gutch, Ronak Tilvawala, Archie C. Reyes, Nicoletta Sorvillo, Denisa D. Wagner, Deya Cherpokova, Paul R. Thompson, Ari J. Salinger, Saeko Fukui
Publikováno v:
Cell Chem Biol
Summary Aberrant protein citrullination is associated with many pathologies; however, the specific effects of this modification remain unknown. We have previously demonstrated that serine protease inhibitors (SERPINs) are highly citrullinated in rheu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f6e6ebb43527063d7083d7d8145cce67
https://doi.org/10.1016/j.chembiol.2021.07.009
https://doi.org/10.1016/j.chembiol.2021.07.009