Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Archie A. Khan"'
Autor:
Archie A. Khan, Harry C. Langston, Louis Walsh, Rebecca Roscoe, Shiromani Jayawardhana, Amanda Fortes Francisco, Martin C. Taylor, Conor J. McCann, John M. Kelly, Michael D. Lewis
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-16 (2024)
Abstract Digestive Chagas disease (DCD) is an enteric neuropathy caused by Trypanosoma cruzi infection. There is a lack of evidence on the mechanism of pathogenesis and rationales for treatment. We used a female C3H/HeN mouse model that recapitulates
Externí odkaz:
https://doaj.org/article/a4a52838d7184b1199e085504845f411
Autor:
Alexandra L. Petrache, Archie A. Khan, Martin W. Nicholson, Alessandra Monaco, Martyna Kuta-Siejkowska, Shozeb Haider, Stephen Hilton, Jasmina N. Jovanovic, Afia B. Ali
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 14 (2020)
Selective negative allosteric modulators (NAMs), targeting α5 subunit-containing GABAA receptors (GABAARs) as potential therapeutic targets for disorders associated with cognitive deficits, including Alzheimer’s disease (AD), continually fail clin
Externí odkaz:
https://doaj.org/article/5adb6257652149dda4942e7f037cacbc
Autor:
Alexander I. Ward, Michael D. Lewis, Archie A. Khan, Conor J. McCann, Amanda F. Francisco, Shiromani Jayawardhana, Martin C. Taylor, John M. Kelly
Publikováno v:
mBio, Vol 11, Iss 4 (2020)
ABSTRACT Infections with Trypanosoma cruzi are usually lifelong despite generating a strong adaptive immune response. Identifying the sites of parasite persistence is therefore crucial to understanding how T. cruzi avoids immune-mediated destruction.
Externí odkaz:
https://doaj.org/article/74fc772af41a456994e952224e9e0ba2
Autor:
Archie A. Khan, Harry C. Langston, Louis Walsh, Rebecca Roscoe, Shiromani Jayawardhana, Amanda F. Francisco, Martin C. Taylor, Conor J. McCann, John M. Kelly, Michael D. Lewis
Digestive Chagas disease (DCD) is an enteric neuropathy caused byTrypanosoma cruziinfection. There is a lack of evidence on the mechanism of pathogenesis and rationales for treatment. We used a mouse model that recapitulates key clinical manifestatio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6d8830b7146cca5887a0b2a88a57d68a
https://doi.org/10.1101/2022.12.14.520395
https://doi.org/10.1101/2022.12.14.520395
Autor:
Francisco Olmo, Fernanda C. Costa, John M. Kelly, Conor J. McCann, Michael D. Lewis, Harry C Langston, Martin C. Taylor, Archie A Khan
Publikováno v:
PLoS Pathogens
PLoS Pathogens, Vol 17, Iss 8, p e1009864 (2021)
PLoS Pathogens, Vol 17, Iss 8, p e1009864 (2021)
Digestive Chagas disease (DCD) is an enteric neuropathy caused by Trypanosoma cruzi infection. The mechanism of pathogenesis is poorly understood and the lack of a robust, predictive animal model has held back research. We screened a series of mouse
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::459ad9da32ac2c8815af7c01581fb173
Autor:
Conor J. McCann, Martin C. Taylor, John M. Kelly, Archie A Khan, Alexander I. Ward, Amanda F. Francisco, Michael D. Lewis, Shiromani Jayawardhana
Infections with Trypanosoma cruzi are usually life-long despite generating a strong adaptive immune response. Identifying the sites of parasite persistence is therefore crucial to understand how T. cruzi avoids immune-mediated destruction. However, t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2f2adad3e0ac52f4f525934d74da16f5
https://doi.org/10.1101/2020.05.13.092551
https://doi.org/10.1101/2020.05.13.092551
Publikováno v:
British Journal of Pharmacology
Background and Purpose A non‐psychoactive phytocannabinoid, cannabidiol (CBD), shows promising results as an effective potential antiepileptic drug in some forms of refractory epilepsy. To elucidate the mechanisms by which CBD exerts its anti‐sei
Autor:
Harry Langston, Amanda Fortes Francisco, Ciaran Doidge, Chrissy H Roberts, Archie A Khan, Shiromani Jayawardhana, Martin C Taylor, John M Kelly, Michael D Lewis
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 18, Iss 6, p e0012278 (2024)
Chagas disease is a zoonosis caused by the protozoan parasite Trypanosoma cruzi. Clinical outcomes range from long-term asymptomatic carriage to cardiac, digestive, neurological and composite presentations that can be fatal in both acute and chronic
Externí odkaz:
https://doaj.org/article/6807b2b04f02489989bb08c3986bec76
Autor:
Archie A Khan, Harry C Langston, Fernanda C Costa, Francisco Olmo, Martin C Taylor, Conor J McCann, John M Kelly, Michael D Lewis
Publikováno v:
PLoS Pathogens, Vol 17, Iss 8, p e1009864 (2021)
Digestive Chagas disease (DCD) is an enteric neuropathy caused by Trypanosoma cruzi infection. The mechanism of pathogenesis is poorly understood and the lack of a robust, predictive animal model has held back research. We screened a series of mouse
Externí odkaz:
https://doaj.org/article/ce5e49f6159a4b51957df35aa743d66a
Autor:
Francisco AF; Department of Infection Biology, London School of Hygiene and Tropical Medicine, London WC1E 7HT, UK., Sousa GR; Harvard Medical School, Section on Immunobiology, Joslin Diabetes Center, 1 Joslin Place, Boston, MA 02215, USA., Vaughan M; Research Department of Haematology, Cancer Institute, Faculty of Medical Sciences, University College London, London WC1E 6DD, UK., Langston H; Department of Infection Biology, London School of Hygiene and Tropical Medicine, London WC1E 7HT, UK., Khan A; Department of Infection Biology, London School of Hygiene and Tropical Medicine, London WC1E 7HT, UK., Jayawardhana S; Department of Infection Biology, London School of Hygiene and Tropical Medicine, London WC1E 7HT, UK., Taylor MC; Department of Infection Biology, London School of Hygiene and Tropical Medicine, London WC1E 7HT, UK., Lewis MD; Department of Infection Biology, London School of Hygiene and Tropical Medicine, London WC1E 7HT, UK., Kelly JM; Department of Infection Biology, London School of Hygiene and Tropical Medicine, London WC1E 7HT, UK.
Publikováno v:
Pathogens (Basel, Switzerland) [Pathogens] 2023 Nov 17; Vol. 12 (11). Date of Electronic Publication: 2023 Nov 17.