Zobrazeno 1 - 10
of 72
pro vyhledávání: '"Archibald S. Perkins"'
Autor:
Edward Ayoub, Michael P. Wilson, Kathleen E. McGrath, Allison J. Li, Benjamin J. Frisch, James Palis, Laura M. Calvi, Yi Zhang, Archibald S. Perkins
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-12 (2018)
Chr3q26 rearrangements cause overexpression of EVI1 and associate with myeloid neoplasms, but the mechanism behind this association is unclear. Here, using a novel mouse model they show that EVI1 causes premalignant myeloid expansion with suppression
Externí odkaz:
https://doaj.org/article/7ab778ef571e43deb286e077ef67c640
Autor:
Sergei A. Vinogradov, Negar Seyedhassantehrani, Archibald S. Perkins, Tatiana V. Esipova, Azucena Ramos, Guoji Guo, Charles P. Lin, Raffaele A. Calogero, Joel A. Spencer, Riccardo Panero, Constantina Christodoulou, Stuart H. Orkin, Sarah Rudzinskas, Raphaël Turcotte, Shu-Chi A. Yeh, Timm Schroeder, Konstantinos D. Kokkaliaris, Yi Zhang, Fernando D. Camargo
Publikováno v:
Nature
The biology of hematopoietic stem cells (HSCs) has predominantly been studied under transplantation conditions1,2. Particularly challenging has been the study of dynamic HSC behaviors given that live animal HSC visualization in the native niche still
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::08a4eedb6ab64fc6eed1e10bd3e42e40
http://europepmc.org/articles/PMC7021587
http://europepmc.org/articles/PMC7021587
Autor:
Cai Ping Koh, Avinash Govind Bahirvani, Chelsia Qiuxia Wang, Tomomasa Yokomizo, Cherry Ee Lin Ng, Linsen Du, Vinay Tergaonkar, Dominic Chih-Cheng Voon, Hiroaki Kitamura, Hiroki Hosoi, Takashi Sonoki, Mok Meng Huang Michelle, Lii Jye Tan, Akiko Niibori-Nambu, Yi Zhang, Archibald S. Perkins, Zakir Hossain, Daniel G. Tenen, Yoshiaki Ito, Byrappa Venkatesh, Motomi Osato
Publikováno v:
Gene. 851:147049
A cis-regulatory genetic element which targets gene expression to stem cells, termed stem cell enhancer, serves as a molecular handle for stem cell-specific genetic engineering. Here we show the generation and characterization of a tamoxifen-inducibl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cf8e1e2f6ef13f4828e21c4e4419664f
https://doi.org/10.1016/j.gene.2022.147049
https://doi.org/10.1016/j.gene.2022.147049
Autor:
Cherry Ee Lin Ng, Daniel G. Tenen, Cai Ping Koh, Takashi Sonoki, Vinay Tergaonkar, Yi Zhang, Archibald S. Perkins, Avinash Govind Bahirvani, Zakir Hossain, Linsen Du, Byrappa Venkatesh, Tomomasa Yokomizo, Chelsia Qiuxia Wang, Akiko Niibori-Nambu, Motomi Osato, Yoshiaki Ito, Hiroki Hosoi, Dominic Chih-Cheng Voon, Michelle Meng Huang Mok
SummaryA cis-regulatory genetic element which targets gene expression to stem cells, termed stem cell enhancer, serves as a molecular handle for stem cell-specific genetic engineering. Here we show the generation and characterization of a tamoxifen-i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::25c73b879a353eafa22afa7a90687302
https://doi.org/10.1101/2021.11.24.469958
https://doi.org/10.1101/2021.11.24.469958
Autor:
Emilie A Bard-Chapeau, Dorota Szumska, Bindya Jacob, Belinda Q L Chua, Gouri C Chatterjee, Yi Zhang, Jerrold M Ward, Fatma Urun, Emi Kinameri, Stéphane D Vincent, Sayadi Ahmed, Shoumo Bhattacharya, Motomi Osato, Archibald S Perkins, Adrian W Moore, Nancy A Jenkins, Neal G Copeland
Publikováno v:
PLoS ONE, Vol 9, Iss 2, p e89397 (2014)
The ecotropic viral integration site 1 (Evi1) oncogenic transcription factor is one of a number of alternative transcripts encoded by the Mds1 and Evi1 complex locus (Mecom). Overexpression of Evi1 has been observed in a number of myeloid disorders a
Externí odkaz:
https://doaj.org/article/effd38105d7245568043cd9f308454a6
Autor:
Loralei L. Thornburg, Stefanie J. Hollenbach, Archibald S. Perkins, Marika Toscano, Elizabeth Westen
Publikováno v:
Case Reports in Perinatal Medicine. 9
Background Hemophagocytic lymphohistiocytosis (HLH) is a rare and life-threatening disease. It is characterized by impaired natural killer cell and cytotoxic lymphocyte function leading to dysregulated macrophage phagocytosis of erythrocytes, leukocy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c1f4bb38ec3743468a07f022ccbcc0f1
https://doi.org/10.1515/crpm-2019-0046
https://doi.org/10.1515/crpm-2019-0046
Autor:
Laura M. Calvi, Edward Ayoub, James Palis, Kathleen E. McGrath, Archibald S. Perkins, Allison J. Li, Michael P Wilson, Yi Zhang, Benjamin J. Frisch
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-12 (2018)
Nature Communications
Nature Communications
Inv(3q26) and t(3:3)(q21;q26) are specific to poor-prognosis myeloid malignancies, and result in marked overexpression of EVI1, a zinc-finger transcription factor and myeloid-specific oncoprotein. Despite extensive study, the mechanism by which EVI1
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5ca2f1e3264ec8bac0a16a913b8a07bb
https://doaj.org/article/7ab778ef571e43deb286e077ef67c640
https://doaj.org/article/7ab778ef571e43deb286e077ef67c640
Publikováno v:
Experimental hematology. 85
Mds1-Evi1 (also known as Prdm3) and Prdm16 are two highly related zinc finger transcription factors that, within the hematopoietic system, are both expressed primarily in hematopoietic stem cells (HSCs). Our laboratory previously found that constitut
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ceca41b7bd120bd1f6d2550b3bb8c7c8
https://pubmed.ncbi.nlm.nih.gov/32437910
https://pubmed.ncbi.nlm.nih.gov/32437910
Autor:
Katherine H. Fegan, Archibald S. Perkins, Yi Zhang, Paul D. Kingsley, Kathleen E. McGrath, Hongbo Yu, James Palis, Edward Ayoub, Sarah Rudzinskas, Kelly A. McGlynn
Publikováno v:
Blood. 138:2153-2153
The ontogeny of the hematopoietic system consists of two broad programs. The first, an HSC-independent program, consists of overlapping waves of primitive, erythro-myeloid (EMP), and some lymphoid progenitors. HSC-independent hematopoiesis is require
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1231929f7493305fdd2cc14a76de2b22
https://doi.org/10.1182/blood-2021-154041
https://doi.org/10.1182/blood-2021-154041
Autor:
Kathleen E. McGrath, Hongbo Yu, Sarah Rudzinskas, Paul D. Kingsley, Edward Ayoub, Yi Zhang, Archibald S. Perkins, Kate Fegan, James Palis, Kelly A. McGlynn
Publikováno v:
Cell Reports. 36:109562
Hematopoietic ontogeny consists of two broad programs: an initial hematopoietic stem cell (HSC)-independent program followed by HSC-dependent hematopoiesis that sequentially seed the fetal liver and generate blood cells. However, the transition from
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a10381921a3bbf3d177a120f65aead2d
https://doi.org/10.1016/j.celrep.2021.109562
https://doi.org/10.1016/j.celrep.2021.109562