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Randomised double-blind placebo-controlled study of interferon beta-1a in relapsing/remitting multiple sclerosis. PRISMS (Prevention of Relapses and Disability by Interferon beta-1a Subcutaneously in Multiple Sclerosis) Study Group

Autor: Ebers, GC, Rice, G, Lesaux, J, Paty, D, Oger, J, Li, DKB, Beall, S, Devonshire, V, Hashimoto, S, Hooge, J, Kastrukoff, L, Krieger, C, Mezei, M, Seland, P, Vorobeychi, G, Morrison, W, Nelson, J, Freedman, MS, Chrisie, S, Nelson, R, Rabinovitch, H, Freedman, C, Hartung, HP, Rieckmann, P, Archelos, J, Jung, S, Weilbach, F, Flachenecke, P, Sauer, J, Hommes, O, Jongen, P, Brouwer, S, McLeod, J, Pollard, J, Ng, R, Sandberg-Wollheim, M, Kallen, K, Nilsson, P, Ekberg, R, Lundgren, A, Jadback, G, Wikstrom, J, Multanen, J, Valjakka, M, Carton, H, Lissoir, F, Declerq, I, Vieren, M, Peeters, E, Dubois, B, Dekeersmaeker, E, Van Herle, A, Hughes, RAC, Sharrack, B, Soudain, S, Panelius, M, Eralinna, J, Soilu-Hanninen, M, Murto, S, Medaer, R, Broeckx, J, Vanroose, E, Bogaers, A, Blumhardt, LD, Edwards, S, Liu, C, Orpe, V, Barnes, D, Schwartz, M, Stoy, N, Harraghy, C, Bertelsmann, F, Uitdehaag, B, Nasseri, K, Chofflon, M, Roth, S, Kappos, L, Huber, S, Bellaiche, Y, Senn, C, King, J, Jubert, J, Whitten, S, Newsom-Davis, JM, Palace, J, Lee, M, Evangelou, N, Pinto, A, Cavey, A, Sindic, CJM, Monteyne, P, Verougstraete, D, Van Doorn, PA, Moll, W, Visser, L, Willems, M, Martina, I, Buljevac, D, Loman, L, Bates, D, Pandit, D, Irving, J, Rhodes, B, Riddehough, A, Zhao, GJ, Wang, X, Cheng, Y, Ammoury, N, Dupont, F, Galazka, A, Hyde, R, Olson, M, Pernin, MO, Abdul-Ahad, AK, Noseworthy, J, Borden, E, O'Brien, P, Wolinsky, J, Grp, PRISMSS

Publikováno v: Lancet. 352(9139)

BACKGROUND: Previous trials of interferon beta in multiple sclerosis (MS) have shown efficacy, but the degree of clinical benefit remains uncertain, and the optimum dose is not known. We undertook a double-blind, placebo-controlled study in relapsing

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od______1064::5693c22c46bfd03de445cd73b4162e50
http://ora.ox.ac.uk/objects/uuid:61d8908f-d676-4725-b673-220d6d81871c

Modulation of the expression of integrins on glial cells during experimental autoimmune encephalomyelitis. A central role for TNF-alpha

Autor: Previtali, S. C., Archelos, J. J., Hartung, H. P.

Integrins comprise a group of adhesion receptors involved in cell-cell and cell-extracellular matrix interactions. Evidence is accumulating that integrins expressed on mononuclear cells play a central role in the induction of autoimmune diseases of t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::fabe23265f67d676cc7eeebc759bc6a4
https://europepmc.org/articles/PMC1858084/

Downregulation of Myelin Associated Glycoprotein (MAG) on Schwann cells by interferon-gamma and tumor necrosis factor-alpha affects neurite outgrowth

Autor: Schneider-Schaulies, Jürgen, Kirchhoff, F., Archelos, J., Schachner, M.

To investigate the influence of inflammatory cytokines on the potential of peripheral nerves to regenerate, we analyzed the effect of interferon-y (lFN-y) and tumor necrosis factor-a (TNF-a) on the ability of immortalized Schwann cells to mediate out

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od_______713::1a9f5c07207e7bdf4e16a396606d3672
https://opus.bibliothek.uni-wuerzburg.de/files/4738/Schneider_Schaulies_J_Downregulation.pdf

Statins as immunomodulators: comparison with interferon-beta 1b in MS.

Autor: Neuhaus, O, Strasser-Fuchs, S, Fazekas, F, Kieseier, B C, Niederwieser, G, Hartung, H P, Archelos, J J

Publikováno v: Neurology; 2002 Oct 8, Vol. 59 Issue 7, p990-997, 8p