Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Arcadio Rubio García"'
Autor:
Niina Sandholm, Arcadio Rubio García, Marcin L. Pekalski, Jamie R. J. Inshaw, Antony J. Cutler, John A. Todd
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-11 (2022)
Abstract We recently mapped a genetic susceptibility locus on chromosome 6q22.33 for type 1 diabetes (T1D) diagnosed below the age of 7 years between the PTPRK and thymocyte-selection-associated (THEMIS) genes. As the thymus plays a central role in s
Externí odkaz:
https://doaj.org/article/b8467bba9920488788059b947110bd92
Autor:
João J. Oliveira, Sarah Karrar, Daniel B. Rainbow, Christopher L. Pinder, Pamela Clarke, Arcadio Rubio García, Osama Al-Assar, Keith Burling, Sian Morris, Richard Stratton, Tim J. Vyse, Linda S. Wicker, John A. Todd, Ricardo C. Ferreira
Publikováno v:
Arthritis Research & Therapy, Vol 20, Iss 1, Pp 1-13 (2018)
Abstract Background The molecular heterogeneity of autoimmune and inflammatory diseases has been one of the main obstacles to the development of safe and specific therapeutic options. Here, we evaluated the diagnostic and clinical value of a robust,
Externí odkaz:
https://doaj.org/article/66741b78262f4fd8a97efd4d6ee4e01c
Autor:
Oliver S. Burren, Arcadio Rubio García, Biola-Maria Javierre, Daniel B. Rainbow, Jonathan Cairns, Nicholas J. Cooper, John J. Lambourne, Ellen Schofield, Xaquin Castro Dopico, Ricardo C. Ferreira, Richard Coulson, Frances Burden, Sophia P. Rowlston, Kate Downes, Steven W. Wingett, Mattia Frontini, Willem H. Ouwehand, Peter Fraser, Mikhail Spivakov, John A. Todd, Linda S. Wicker, Antony J. Cutler, Chris Wallace
Publikováno v:
Genome Biology, Vol 18, Iss 1, Pp 1-19 (2017)
Abstract Background Autoimmune disease-associated variants are preferentially found in regulatory regions in immune cells, particularly CD4+ T cells. Linking such regulatory regions to gene promoters in disease-relevant cell contexts facilitates iden
Externí odkaz:
https://doaj.org/article/a2ac010742a3449aa23a667a36cbedcf
Autor:
Ricardo C. Ferreira, Daniel B. Rainbow, Arcadio Rubio García, Marcin L. Pekalski, Linsey Porter, João J. Oliveira, Frank Waldron-Lynch, Linda S. Wicker, John A. Todd
Publikováno v:
Data in Brief, Vol 12, Iss C, Pp 676-691 (2017)
We provide in this paper a detailed characterization of the human peripheral CD4+ CD127lowCD25+ regulatory T cell (Treg) compartment, with a particular emphasis in defining the population expressing higher levels of the IL-6 receptor (IL-6R). We prov
Externí odkaz:
https://doaj.org/article/118550356a274a4582df91b80dc090ad
Autor:
Chris Wallace, Antony J Cutler, Nikolas Pontikos, Marcin L Pekalski, Oliver S Burren, Jason D Cooper, Arcadio Rubio García, Ricardo C Ferreira, Hui Guo, Neil M Walker, Deborah J Smyth, Stephen S Rich, Suna Onengut-Gumuscu, Stephen J Sawcer, Maria Ban, Sylvia Richardson, John A Todd, Linda S Wicker
Publikováno v:
PLoS Genetics, Vol 11, Iss 6, p e1005272 (2015)
Identification of candidate causal variants in regions associated with risk of common diseases is complicated by linkage disequilibrium (LD) and multiple association signals. Nonetheless, accurate maps of these variants are needed, both to fully expl
Externí odkaz:
https://doaj.org/article/07890477c158413ba3b6207964cdda3f
Autor:
Arcadio Rubio García, Athina Paterou, Rebecca D. Powell Doherty, Laurie G. Landry, Mercede Lee, Amanda M. Anderson, Hubert Slawinski, Ricardo C. Ferreira, Dominik Trzupek, Agnieszka Szypowska, Linda S. Wicker, Luc Teyton, Nicola Ternette, Maki Nakayama, John A. Todd, Marcin L. Pekalski
Type 1 diabetes (T1D) is caused by a T-cell-mediated destruction of insulin-secreting pancreatic islet β cells. The T1D-predisposing human leukocyte antigen (HLA) class II molecule, DQ8, binds and presents insulin B chain peptides in the thymus prod
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::088d2857e527d780bc0ac671af83e408
https://doi.org/10.1101/2022.05.11.22274678
https://doi.org/10.1101/2022.05.11.22274678
Autor:
John A. Todd, Niina Sandholm, Marcin L. Pekalski, Antony J. Cutler, Arcadio Rubio García, Jamie Inshaw
We recently mapped a genetic susceptibility locus on chromosome 6q22.33 for type 1 diabetes diagnosed below age of 7 years near the gene Protein tyrosine phosphatase receptor type K (PTPRK) and the thymocyte selection associated gene (THEMIS). As the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::01085b80c13a64a43f7807d5566b1272
https://doi.org/10.1101/2021.09.17.460789
https://doi.org/10.1101/2021.09.17.460789
Autor:
Arcadio Rubio García, Mercede Lee, Laurie G. Landry, Hubert Sławiński, Dominik Trzupek, John A. Todd, Maki Nakayama, Luc Teyton, Marcin Ł. Pękalski, Ricardo C. Ferreira, Athina Paterou, Agnieszka Szypowska, Linda S. Wicker
Type 1 diabetes (T1D) is a common autoimmune disorder characterized by the destruction of insulin-secreting pancreatic β cells [1], in which polymorphism of the human leukocyte antigen (HLA) class II region is the major genetic risk factor [2, 3, 4]
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2ce1a8c72db764d6107365947f420f72
https://doi.org/10.1101/2021.09.06.458974
https://doi.org/10.1101/2021.09.06.458974
Autor:
Mercede Lee, Linda S. Wicker, Athina Paterou, Marcin Ł. Pękalski, Arcadio Rubio García, John A. Todd, Hubert Sławiński
How organisms achieve sustained peripheral tolerance throughout their lifetime, a correct immune discrimination between self and non-self, remains poorly understood. Host-microbiome interactions carry fundamental information that facilitates this pro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bd5ca7bbcf7433ea69ae6ebadebbd3d2
https://doi.org/10.1101/2019.12.18.881433
https://doi.org/10.1101/2019.12.18.881433
Autor:
Pamela Clarke, John A. Todd, Sarah Karrar, Linda S. Wicker, Arcadio Rubio García, Ricardo C. Ferreira, Osama Al-Assar, Daniel B. Rainbow, João J. Oliveira, Timothy J. Vyse, Christopher L. Pinder, Keith Burling
The molecular heterogeneity of autoimmune and inflammatory diseases has been one of the main obstacles to the development of safe and specific therapeutic options. Here we have evaluated the diagnostic and clinical value of a robust, inexpensive, imm
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b1742518f63295cea53a7c4f8f161b81