Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Aravindan Jayaraman"'
Autor:
Yuhong Wang, Xiang Ma, Parthasarathy Muthuraman, Arun Raja, Aravindan Jayaraman, Konstantin Petrukhin, Christopher L Cioffi, Jian-Xing Ma, Gennadiy Moiseyev
Publikováno v:
PLoS ONE, Vol 17, Iss 10, p e0269437 (2022)
The visual cycle refers to a series of biochemical reactions of retinoids in ocular tissues and supports the vision in vertebrates. The visual cycle regenerates visual pigments chromophore, 11-cis-retinal, and eliminates its toxic byproducts from the
Externí odkaz:
https://doaj.org/article/0ca8d457ef61443d85b15c1f866ee4b4
Autor:
Charles S. Shanahan, Appasaheb L. Kadam, Barreddi Chiranjeevi, Aline A. Nunes, Aravindan Jayaraman, Saeed Ahmad, Sarah L. Aleshire, Kai O. Donsbach, B. Frank Gupton, Michel C. Nuckols
Nirmatrelvir, the novel antiviral component of Pfizer’s orally available combination therapy Paxlovid, used to treat COVID-19, presents a significant synthetic challenge. Herein, we report process optimization insights that could enable a scalable
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a2a3122a9a6b3664e212d2ce214e878a
https://doi.org/10.26434/chemrxiv-2022-cn0k1
https://doi.org/10.26434/chemrxiv-2022-cn0k1
Amides Activation: Transition Metal‐Free Coupling Between CN Activated Amides and Enolizable Amides
Publikováno v:
Bulletin of the Korean Chemical Society. 42:1293-1295
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3933c42bced238f07fc8ee8d45d14445
https://doi.org/10.1002/bkcs.12371
https://doi.org/10.1002/bkcs.12371
Autor:
Aravindan Jayaraman, Sunwoo Lee
Publikováno v:
Organic Letters. 21:7923-7927
Palladium-catalyzed decarboxylative coupling reactions using alkynoic acids and 1-fluoro-2,2-diiodovinylarenes provide mono- and dialkynylfluoroalkenes with high selectivity. When the reaction was conducted using DBU/DMSO, the hydrodeiodinated monoal
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b9191d4623b6645727a1748e756cd1c2
https://doi.org/10.1021/acs.orglett.9b02907
https://doi.org/10.1021/acs.orglett.9b02907
Publikováno v:
Advanced Synthesis & Catalysis. 361:1846-1858
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f7cc6412df813e2ce85169194d6602c7
https://doi.org/10.1002/adsc.201801535
https://doi.org/10.1002/adsc.201801535
Autor:
Boglarka Racz, Srinivasan Jayakumar, Konstantin Petrukhin, Christopher L. Cioffi, Parthasarathy Muthuraman, Arun Raja, Aravindan Jayaraman, András Váradi
Publikováno v:
J Med Chem
Dissociation of transthyretin (TTR) tetramers may lead to misfolding and aggregation of proamyloidogenic monomers, which underlies TTR amyloidosis (ATTR) pathophysiology. ATTR is a progressive disease resulting from the deposition of toxic fibrils in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bda8a7259834e8e431ac643fcc5d749f
https://europepmc.org/articles/PMC9578043/
https://europepmc.org/articles/PMC9578043/
Autor:
Konstantin Petrukhin, Boglarka Racz, Andras Varadi, Srinivasan Jayakumar, Aravindan Jayaraman, Parthasarathy Muthuraman, Arun Raja, Christopher L. Cioffi
Dissociation of transthyretin (TTR) tetramers may lead to misfolding and aggregation of pro-amyloidogenic monomers, which underlies TTR amyloidosis (ATTR) pathophysiology. ATTR is a progressive disease resulting from the deposition of toxic fibrils i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ca328669e1c1f884ca5a6bf344ee148c
https://doi.org/10.26434/chemrxiv.14102813
https://doi.org/10.26434/chemrxiv.14102813
Publikováno v:
Advanced Synthesis & Catalysis. 360:3978-3989
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9f4f6464f7484b2cd0a2363fd487a3fa
https://doi.org/10.1002/adsc.201800851
https://doi.org/10.1002/adsc.201800851
Publikováno v:
European Journal of Organic Chemistry. 2018:781-784
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::79bc1fa715ae5e109ea88d72bc9a36a3
https://doi.org/10.1002/ejoc.201701640
https://doi.org/10.1002/ejoc.201701640
Publikováno v:
Advanced Synthesis & Catalysis. 360:130-141
2,2,2-Trichloroacetophenone derivatives were synthesized via decarboxylative trichlorination from arylpropiolic acids and trichloroisocyanuric acid (TCCA). The reaction was conducted in the presence of H2O (water) at room temperature, and afforded th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2ca34dcf23d29f34cdfc9f67b1420aff
https://doi.org/10.1002/adsc.201701116
https://doi.org/10.1002/adsc.201701116