Kupffer cell-like syncytia replenish resident macrophage function in the fibrotic liver.

Autor: Peiseler M; Department of Physiology and Pharmacology, University of Calgary, Calgary, Alberta, Canada.; Snyder Institute for Chronic Diseases, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada.; Department of Hepatology and Gastroenterology, Charité Universitätsmedizin Berlin, Campus Virchow Klinikum and Campus Charité Mitte, Berlin, Germany.; Berlin Institute of Health (BIH), Berlin, Germany., Araujo David B; Department of Physiology and Pharmacology, University of Calgary, Calgary, Alberta, Canada.; Snyder Institute for Chronic Diseases, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada., Zindel J; Department of Physiology and Pharmacology, University of Calgary, Calgary, Alberta, Canada.; Snyder Institute for Chronic Diseases, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada.; Department of Visceral Surgery and Medicine, Department for BioMedical Research (DBMR), University of Bern, Bern, Switzerland., Surewaard BGJ; Department of Physiology and Pharmacology, University of Calgary, Calgary, Alberta, Canada.; Snyder Institute for Chronic Diseases, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada., Lee WY; Department of Physiology and Pharmacology, University of Calgary, Calgary, Alberta, Canada.; Snyder Institute for Chronic Diseases, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada., Heymann F; Department of Hepatology and Gastroenterology, Charité Universitätsmedizin Berlin, Campus Virchow Klinikum and Campus Charité Mitte, Berlin, Germany., Nusse Y; Department of Physiology and Pharmacology, University of Calgary, Calgary, Alberta, Canada.; Snyder Institute for Chronic Diseases, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada., Castanheira FVS; Department of Physiology and Pharmacology, University of Calgary, Calgary, Alberta, Canada.; Snyder Institute for Chronic Diseases, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada., Shim R; Department of Physiology and Pharmacology, University of Calgary, Calgary, Alberta, Canada.; Snyder Institute for Chronic Diseases, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada., Guillot A; Department of Hepatology and Gastroenterology, Charité Universitätsmedizin Berlin, Campus Virchow Klinikum and Campus Charité Mitte, Berlin, Germany., Bruneau A; Department of Hepatology and Gastroenterology, Charité Universitätsmedizin Berlin, Campus Virchow Klinikum and Campus Charité Mitte, Berlin, Germany., Atif J; Ajmera Transplant Centre, Toronto General Research Institute, University Health Network, Toronto, Ontario, Canada., Perciani C; Ajmera Transplant Centre, Toronto General Research Institute, University Health Network, Toronto, Ontario, Canada., Ohland C; Department of Physiology and Pharmacology, University of Calgary, Calgary, Alberta, Canada.; Snyder Institute for Chronic Diseases, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada., Ganguli Mukherjee P; Department of Cell Biology and Anatomy, University of Calgary, Calgary, Alberta, Canada., Niehrs A; Leibniz Institute of Virology (LIV), Hamburg, Germany., Thuenauer R; Leibniz Institute of Virology (LIV), Hamburg, Germany., Altfeld M; Leibniz Institute of Virology (LIV), Hamburg, Germany., Amrein M; Department of Cell Biology and Anatomy, University of Calgary, Calgary, Alberta, Canada., Liu Z; Shanghai Institute of Immunology, Department of Immunology and Microbiology, Shanghai Jiao Tong University School of Medicine, Shanghai, China., Gordon PMK; Centre for Health Genomics and Informatics, University of Calgary, Calgary, Alberta, Canada., McCoy K; Department of Physiology and Pharmacology, University of Calgary, Calgary, Alberta, Canada.; Snyder Institute for Chronic Diseases, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada.; Department of Microbiology, Immunology and Infectious Diseases, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada., Deniset J; Department of Physiology and Pharmacology, University of Calgary, Calgary, Alberta, Canada.; Snyder Institute for Chronic Diseases, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada.; Department of Cardiac Sciences, University of Calgary, Calgary, Alberta, Canada.; Libin Cardiovascular Institute, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada., MacParland S; Ajmera Transplant Centre, Toronto General Research Institute, University Health Network, Toronto, Ontario, Canada., Ginhoux F; Singapore Immunology Network (SIgN), Agency for Science, Technology and Research (A*STAR), Singapore, Singapore.; Gustave Roussy Cancer Campus, INSERM U1015, Villejuif, France., Tacke F; Department of Hepatology and Gastroenterology, Charité Universitätsmedizin Berlin, Campus Virchow Klinikum and Campus Charité Mitte, Berlin, Germany., Kubes P; Department of Physiology and Pharmacology, University of Calgary, Calgary, Alberta, Canada.; Snyder Institute for Chronic Diseases, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada.

Publikováno v: Science (New York, N.Y.) [Science] 2023 Sep 08; Vol. 381 (6662), pp. eabq5202. Date of Electronic Publication: 2023 Sep 08.