Zobrazeno 1 - 10
of 132
pro vyhledávání: '"Arata Fukushima"'
Autor:
Ryosuke Shirakawa, Takayuki Nakajima, Aya Yoshimura, Yukako Kawahara, Chieko Orito, Miwako Yamane, Haruka Handa, Shingo Takada, Takaaki Furihata, Arata Fukushima, Naoki Ishimori, Masao Nakagawa, Isao Yokota, Hisataka Sabe, Satoshi Hashino, Shintaro Kinugawa, Takashi Yokota
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-3 (2024)
Externí odkaz:
https://doaj.org/article/aad6a0e84f90434db628ed57404fb939
Autor:
Ryosuke Shirakawa, Takayuki Nakajima, Aya Yoshimura, Yukako Kawahara, Chieko Orito, Miwako Yamane, Haruka Handa, Shingo Takada, Takaaki Furihata, Arata Fukushima, Naoki Ishimori, Masao Nakagawa, Isao Yokota, Hisataka Sabe, Satoshi Hashino, Shintaro Kinugawa, Takashi Yokota
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-8 (2023)
Abstract Systemic inflammation underlies the association between obesity and nonalcoholic fatty liver disease (NAFLD). Here, we investigated functional changes in leukocytes’ mitochondria in obese individuals and their associations with NAFLD. We a
Externí odkaz:
https://doaj.org/article/46e186079e8f4cfe8984d0fe4da74e75
Autor:
Takaaki Furihata, Shingo Takada, Naoya Kakutani, Satoshi Maekawa, Masaya Tsuda, Junichi Matsumoto, Wataru Mizushima, Arata Fukushima, Takashi Yokota, Nobuyuki Enzan, Shouji Matsushima, Haruka Handa, Yoshizuki Fumoto, Junko Nio-Kobayashi, Toshihiko Iwanaga, Shinya Tanaka, Hiroyuki Tsutsui, Hisataka Sabe, Shintaro Kinugawa
Publikováno v:
Communications Biology, Vol 4, Iss 1, Pp 1-11 (2021)
Takaaki Furihata et al. report a new mouse model with heart-specific deletion of the mitochondrial protein, mitoNEET. Their results suggest that loss of mitoNEET expression may contribute to age-associated heart failure in older adults.
Externí odkaz:
https://doaj.org/article/3f63983eae254d919bb87225d2d4c10c
Autor:
Takashi Yokota, Shintaro Kinugawa, Kagami Hirabayashi, Mayumi Yamato, Shingo Takada, Tadashi Suga, Ippei Nakano, Arata Fukushima, Shouji Matsushima, Koichi Okita, Hiroyuki Tsutsui
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-8 (2021)
Abstract Oxidative stress plays a role in the progression of chronic heart failure (CHF). We investigated whether systemic oxidative stress is linked to exercise intolerance and skeletal muscle abnormalities in patients with CHF. We recruited 30 male
Externí odkaz:
https://doaj.org/article/5e142f76e7354e2282f7dc210ec5e4bb
Autor:
Takahiro Abe, Takashi Yokota, Arata Fukushima, Naoya Kakutani, Takashi Katayama, Ryosuke Shirakawa, Satoshi Maekawa, Hideo Nambu, Yoshikuni Obata, Katsuma Yamanashi, Ippei Nakano, Shingo Takada, Isao Yokota, Koichi Okita, Shintaro Kinugawa, Toshihisa Anzai
Publikováno v:
Cardiovascular Diabetology, Vol 19, Iss 1, Pp 1-10 (2020)
Abstract Background Although type 2 diabetes mellitus (T2DM) is one of the most frequent comorbidities in patients with chronic heart failure (CHF), the effects of T2DM on the exercise capacity of CHF patients are fully unknown. Here, we tested the h
Externí odkaz:
https://doaj.org/article/55907e3e25c64eb583466ef8482f1d7b
Autor:
Naoya Kakutani, Shingo Takada, Hideo Nambu, Junichi Matsumoto, Takaaki Furihata, Takashi Yokota, Arata Fukushima, Shintaro Kinugawa
Publikováno v:
Skeletal Muscle, Vol 10, Iss 1, Pp 1-10 (2020)
Abstract Background Transforming growth factor beta (TGF-β)-Smad2/3 is the major signaling pathway of fibrosis, which is characterized by the excessive production and accumulation of extracellular matrix (ECM) components, including collagen. Althoug
Externí odkaz:
https://doaj.org/article/9f3ea013100c4153ba258f1957e6b740
Autor:
Golam M. Uddin, Liyan Zhang, Saumya Shah, Arata Fukushima, Cory S. Wagg, Keshav Gopal, Rami Al Batran, Simran Pherwani, Kim L. Ho, Jamie Boisvenue, Qutuba G. Karwi, Tariq Altamimi, David S. Wishart, Jason R. B. Dyck, John R. Ussher, Gavin Y. Oudit, Gary D. Lopaschuk
Publikováno v:
Cardiovascular Diabetology, Vol 18, Iss 1, Pp 1-12 (2019)
Abstract Background Branched chain amino acids (BCAA) can impair insulin signaling, and cardiac insulin resistance can occur in the failing heart. We, therefore, determined if cardiac BCAA accumulation occurs in patients with dilated cardiomyopathy (
Externí odkaz:
https://doaj.org/article/1825257d7b364b2bb61f4a044c96565b
Autor:
Wei Wang, MD, PhD, Liyan Zhang, PhD, Pavan K. Battiprolu, PhD, Arata Fukushima, MD, PhD, Khanh Nguyen, BS, Kenneth Milner, BS, Abhishek Gupta, PhD, Tariq Altamimi, PhD, Nikole Byrne, BS, Jun Mori, MD, PhD, Osama Abo Alrob, PhD, Cory Wagg, Natasha Fillmore, PhD, Shao-hua Wang, MD, PhD, Dongming M. Liu, BS, Angela Fu, BS, Jenny Yinglin Lu, BS, Mary Chaves, MS, Alykhan Motani, PhD, John R. Ussher, PhD, Jeff D. Reagan, PhD, Jason R.B. Dyck, PhD, Gary D. Lopaschuk, PhD
Publikováno v:
JACC: Basic to Translational Science, Vol 4, Iss 3, Pp 385-400 (2019)
Summary: Alterations in cardiac energy metabolism after a myocardial infarction contribute to the severity of heart failure (HF). Although fatty acid oxidation can be impaired in HF, it is unclear if stimulating fatty acid oxidation is a desirable ap
Externí odkaz:
https://doaj.org/article/79de453a1dda4adb8a04a801a0ccb1d3
Mitochondrial respiration of complex II is not lower than that of complex I in mouse skeletal muscle
Autor:
Satoshi Maekawa, Shingo Takada, Takaaki Furihata, Arata Fukushima, Takashi Yokota, Shintaro Kinugawa
Publikováno v:
Biochemistry and Biophysics Reports, Vol 21, Iss , Pp - (2020)
Skeletal muscle (SKM) requires a large amount of energy, which is produced mainly by mitochondria, for their daily functioning. Of the several mitochondrial complexes, it has been reported that the dysfunction of complex II is associated with several
Externí odkaz:
https://doaj.org/article/8252122ff27743e88f80f153383f71aa
Autor:
Masaya Tsuda, Arata Fukushima, Junichi Matsumoto, Shingo Takada, Naoya Kakutani, Hideo Nambu, Katsuma Yamanashi, Takaaki Furihata, Takashi Yokota, Koichi Okita, Shintaro Kinugawa, Toshihisa Anzai
Publikováno v:
Journal of Cachexia, Sarcopenia and Muscle, Vol 9, Iss 5, Pp 844-859 (2018)
Abstract Background Exercise intolerance is a common clinical feature and is linked to poor prognosis in patients with heart failure (HF). Skeletal muscle dysfunction, including impaired energy metabolism in the skeletal muscle, is suspected to play
Externí odkaz:
https://doaj.org/article/5be7a25d485d48ddbf56d267d0f98d0c