Zobrazeno 1 - 10
of 113
pro vyhledávání: '"Arash Grakoui"'
Autor:
Mohamed Eisa, Elsa Gomez-Escobar, Nathalie Bédard, Nourtan F. Abdeltawab, Nicol Flores, Sabrina Mazouz, Alizée Fieffé-Bédard, Patrick Sakayan, John Gridley, Mohamed S. Abdel-Hakeem, Julie Bruneau, Arash Grakoui, Naglaa H. Shoukry
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
IntroductionFollicular helper T cells are essential for helping in the maturation of B cells and the production of neutralizing antibodies (NAbs) during primary viral infections. However, their role during recall responses is unclear. Here, we used h
Externí odkaz:
https://doaj.org/article/d03d3dd95f8b4fb3bae433a2d17ed618
Autor:
Piyush Dravid, Satyapramod Murthy, Zayed Attia, Cole Cassady, Rahul Chandra, Sheetal Trivedi, Ashish Vyas, John Gridley, Brantley Holland, Anuradha Kumari, Arash Grakoui, John M Cullen, Christopher M Walker, Himanshu Sharma, Amit Kapoor
Publikováno v:
PLoS Pathogens, Vol 19, Iss 10, p e1011697 (2023)
Immune correlates of hepatitis C virus (HCV) clearance and control remain poorly defined due to the lack of an informative animal model. We recently described acute and chronic rodent HCV-like virus (RHV) infections in lab mice. Here, we developed MH
Externí odkaz:
https://doaj.org/article/3336fcc916264e49a9b6a618c24ae864
Autor:
Ashish Kumar, Tiana C. Rohe, Elizabeth J. Elrod, Abdul G. Khan, Altaira D. Dearborn, Ryan Kissinger, Arash Grakoui, Joseph Marcotrigiano
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-10 (2023)
Hepatitis C virus (HCV) uses a hybrid entry mechanism. Upon exposure to low pH, envelope glycoprotein E2 releases an internal loop into the host membrane. Here we show the amino terminal region is a critical determinant for membrane interaction, prov
Externí odkaz:
https://doaj.org/article/dd08cce7e5a34d5d8a9691bdc5ae1a25
Autor:
Akira Nishio, Sharika Hasan, Heiyoung Park, Nana Park, Jordan H. Salas, Eduardo Salinas, Lela Kardava, Paul Juneau, Nicole Frumento, Guido Massaccesi, Susan Moir, Justin R. Bailey, Arash Grakoui, Marc G. Ghany, Barbara Rehermann
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-16 (2022)
Long-term dynamics of the humoral response to HCV in cured individuals aren’t well understood. Here, Nishio et al. show that virus-neutralizing antibody levels decrease in potency and breadth after cure of chronic hepatitis C, while HCV-specific me
Externí odkaz:
https://doaj.org/article/2d4cf5245d9644afaee0f1a8317aa30a
Autor:
Aaron M. Rosado, Yan Zhang, Hyun-Kyu Choi, Yunfeng Chen, Samuel M. Ehrlich, Fengzhi Jin, Arash Grakoui, Brian D. Evavold, Cheng Zhu
Publikováno v:
APL Bioengineering, Vol 7, Iss 1, Pp 016102-016102-17 (2023)
Interactions between proteins coordinate biological processes in an organism and may impact its responses to changing environments and diseases through feedback systems. Feedback systems function by using changes in the past to influence behaviors in
Externí odkaz:
https://doaj.org/article/5aae22cc85894f19ac854ed479664ab0
Differential immune transcriptomic profiles between vaccinated and resolved HCV reinfected subjects.
Autor:
Sabrina Mazouz, Eduardo Salinas, Nathalie Bédard, Ali Filali, Omar Khedr, Leo Swadling, Mohamed S Abdel-Hakeem, Asiyah Siddique, Eleanor Barnes, Julie Bruneau, Arash Grakoui, Naglaa H Shoukry
Publikováno v:
PLoS Pathogens, Vol 18, Iss 11, p e1010968 (2022)
Successive episodes of hepatitis C virus (HCV) infection represent a unique natural rechallenge experiment to define correlates of long-term protective immunity and inform vaccine development. We applied a systems immunology approach to characterize
Externí odkaz:
https://doaj.org/article/b2d2784ae87745beaff1b98d4364a008
Autor:
Abigail Vanderheiden, Jeronay Thomas, Allison L. Soung, Meredith E. Davis-Gardner, Katharine Floyd, Fengzhi Jin, David A. Cowan, Kathryn Pellegrini, Adrian Creanga, Amarendra Pegu, Alexandrine Derrien-Colemyn, Pei-Yong Shi, Arash Grakoui, Robyn S. Klein, Steven E. Bosinger, Jacob E. Kohlmeier, Vineet D. Menachery, Mehul S. Suthar
Publikováno v:
mBio, Vol 13, Iss 3 (2022)
Externí odkaz:
https://doaj.org/article/12d5b5bafec94e74979569fbd9832892
Autor:
Daniel M. Chopyk, Johnasha D. Stuart, Matthew G. Zimmerman, Jing Wen, Sanjeev Gumber, Mehul S. Suthar, Manoj Thapa, Mark J. Czaja, Arash Grakoui
Publikováno v:
Hepatology Communications, Vol 3, Iss 11, Pp 1435-1449 (2019)
Acetaminophen (APAP)‐induced liver injury is the most common cause of acute liver failure (ALF) in the Western world. APAP toxicity progresses to multiorgan dysfunction and thus has broader whole‐body implications. Importantly, greater 30‐day m
Externí odkaz:
https://doaj.org/article/ac4c9199aa944376a1d82c6fef0fbe8f
Autor:
Abigail Vanderheiden, Jeronay Thomas, Allison L. Soung, Meredith E. Davis-Gardner, Katharine Floyd, Fengzhi Jin, David A. Cowan, Kathryn Pellegrini, Adrian Creanga, Amarendra Pegu, Alexandrine Derrien-Colemyn, Pei-Yong Shi, Arash Grakoui, Robyn S. Klein, Steven E. Bosinger, Jacob E. Kohlmeier, Vineet D. Menachery, Mehul S. Suthar
Publikováno v:
mBio, Vol 12, Iss 6 (2021)
ABSTRACT Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has caused a historic pandemic of respiratory disease (coronavirus disease 2019 [COVID-19]), and current evidence suggests that severe disease is associated with dysregulated immun
Externí odkaz:
https://doaj.org/article/338d7fe83d2f443ab2dd478f383e3881
Publikováno v:
Cells, Vol 9, Iss 2, p 364 (2020)
Cells in the body are actively engaging with their environments that include both biochemical and biophysical aspects. The process by which cells convert mechanical stimuli from their environment to intracellular biochemical signals is known as mecha
Externí odkaz:
https://doaj.org/article/7cc61f6300af4e2198c2dc41244ed355