Zobrazeno 1 - 10
of 45
pro vyhledávání: '"Aras Toker"'
Autor:
Alexander Muik, Jasmin Quandt, Bonny Gaby Lui, Maren Bacher, Sebastian Lutz, Maika Grünenthal, Aras Toker, Jessica Grosser, Orkun Ozhelvaci, Olga Blokhina, Svetlana Shpyro, Isabel Vogler, Nadine Salisch, Özlem Türeci, Ugur Sahin
Publikováno v:
Cell Reports, Vol 43, Iss 8, Pp 114567- (2024)
Summary: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) exposure histories become increasingly complex through original and variant-adapted vaccines and infections with viral variants. Upon exposure to the highly altered Omicron spike g
Externí odkaz:
https://doaj.org/article/6d3ec055e6634edda15eec6aea826f60
Autor:
Jordan Blum, Alexander Muik, Isil Altintas, Friederike Gieseke, Aras Toker, Esther Breij, Tahamtan Ahmadi, Ugur Sahin, Kristel Kemper, Oezlem Tuereci, Kristina Nuermberger, Sina Fellermeier-Kopf, Andrea Imle, Anna-Lena Krause, Lidia Daszkiewicz
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 11, Iss Suppl 1 (2023)
Externí odkaz:
https://doaj.org/article/5b2dfbe7a11a49c1a72650313cf5a53d
Autor:
Alexander Muik, Bonny Gaby Lui, Jasmin Quandt, Huitian Diao, Yunguan Fu, Maren Bacher, Jessica Gordon, Aras Toker, Jessica Grosser, Orkun Ozhelvaci, Katharina Grikscheit, Sebastian Hoehl, Niko Kohmer, Yaniv Lustig, Gili Regev-Yochay, Sandra Ciesek, Karim Beguir, Asaf Poran, Isabel Vogler, Özlem Türeci, Ugur Sahin
Publikováno v:
Cell Reports, Vol 42, Iss 8, Pp 112888- (2023)
Summary: Evolution of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Omicron variant has led to the emergence of sublineages with different patterns of neutralizing antibody evasion. We report that Omicron BA.4/BA.5 breakthrough inf
Externí odkaz:
https://doaj.org/article/9beefa8d290946d3b470f10ccdbe5236
Autor:
Alexander Muik, Isil Altintas, Friederike Gieseke, Kristina B Schoedel, Saskia M Burm, Aras Toker, Theodora W. Salcedo, Dennis Verzijl, David Eisel, Christian Grunwitz, Lena M Kranz, Mathias Vormehr, David P.E. Satijn, Mustafa Diken, Sebastian Kreiter, Kate Sasser, Tahamtan Ahmadi, Özlem Türeci, Esther C.W. Breij, Maria Jure-Kunkel, Ugur Sahin
Publikováno v:
OncoImmunology, Vol 11, Iss 1 (2022)
Immune checkpoint inhibitors (ICI) targeting the PD-1/PD-L1 axis have changed the treatment paradigm for advanced solid tumors; however, many patients experience treatment resistance. In preclinical models 4-1BB co-stimulation synergizes with ICI by
Externí odkaz:
https://doaj.org/article/c2df5e33bb4545efb02c509f371c1d5a
Autor:
Maria Jure-Kunkel, Homer C Adams III, Kate Sasser, Mark Fereshteh, Alexander Muik, Isil Altintas, Friederike Gieseke, Aras Toker, Özlem Türeci, Tahamtan Ahmadi, Ugur Sahin, Dennis Verzijl, Kristina B Schoedel, Jordan M Blum, Bianca Sänger, Saskia M Burm, Eliana Stanganello, Vanessa M Spires, Fulvia Vascotto, Juliane Quinkhardt, Mustafa Diken, David P E Satijn, Sebastian Kreiter, Esther C W Breij
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 10, Iss 6 (2022)
Externí odkaz:
https://doaj.org/article/026b8577fc804412a127d45c0c573c04
Autor:
Maria Jure-Kunkel, Rachelle Kosoff, Mark Fereshteh, Alexander Muik, Isil Altintas, Friederike Gieseke, Kristina Schödel, Theodora Salcedo, Saskia Burm, Aras Toker, Lena Kranz, Mathias Vormehr, David Eisel, Özlem Türeci, Esther Breij, Tahamtan Ahmadi, Ugur Sahin
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 8, Iss Suppl 3 (2020)
Externí odkaz:
https://doaj.org/article/eea14f7713674c8fb51f93a571e8bfb1
Autor:
Heather L. MacGregor, Carlos Garcia-Batres, Azin Sayad, Andrew Elia, Hal K. Berman, Aras Toker, Sarah Rachel Katz, Patricia A. Shaw, Blaise A. Clarke, Sarah Q. Crome, Celine Robert-Tissot, Marcus Q. Bernardini, Linh T. Nguyen, Pamela S. Ohashi
Publikováno v:
OncoImmunology, Vol 8, Iss 12 (2019)
B7-H4, an immune suppressive member of the B7 family, is highly expressed in a wide variety of human malignancies making it an attractive immunotherapeutic target. However, the association between B7-H4 expression in the tumor microenvironment and th
Externí odkaz:
https://doaj.org/article/443f112e10b64daabf241455c47930ef
Autor:
Susanne Herppich, Aras Toker, Beate Pietzsch, Yohko Kitagawa, Naganari Ohkura, Takahisa Miyao, Stefan Floess, Shohei Hori, Shimon Sakaguchi, Jochen Huehn
Publikováno v:
Frontiers in Immunology, Vol 10 (2019)
Regulatory T (Treg) cells mainly develop within the thymus and arise from CD25+Foxp3− (CD25+ TregP) or CD25−Foxp3+ (Foxp3+ TregP) Treg cell precursors resulting in Treg cells harboring distinct transcriptomic profiles and complementary T cell rec
Externí odkaz:
https://doaj.org/article/9a5401e312c7446ebd3e9fe0ba2aedd4
Publikováno v:
Frontiers in Oncology, Vol 9 (2019)
Regulatory T (Treg) cells play crucial roles in health and disease through their immunosuppressive properties against various immune cells. In this review we will focus on the inhibitory role of Treg cells in anti-tumor immunity. We outline how Treg
Externí odkaz:
https://doaj.org/article/482ab719cbcd459d812ef7a3c7201020
Autor:
Ignacio Melero, Maria Jure-Kunkel, Uğur Şahin, Tahamtan Ahmadi, Ulf Forssmann, Özlem Türeci, Kate Sasser, Eleni Lagkadinou, Gaurav Bajaj, Esther C.W. Breij, Sebastian Kreiter, David Satijn, Mustafa Diken, Mark Fereshteh, Edward N. van den Brink, Aras Toker, Theo S. Plantinga, Juliane Quinkhardt, Angelica Sette, Fulvia Vascotto, Dennis Verzijl, Eliana Stanganello, Saskia M. Burm, Theodora W. Salcedo, Bianca Sänger, Jordan M. Blum, Kristina B. Schoedel, Maria E. Rodriguez-Ruiz, Guzman Alonso, Patricia M. LoRusso, Emiliano Calvo, Corinne Maurice-Dror, Eytan Ben-Ami, Ravit Geva, Friederike Gieseke, Isil Altintas, Elena Garralda, Alexander Muik
Checkpoint inhibitors (CPI) have revolutionized the treatment paradigm for advanced solid tumors; however, there remains an opportunity to improve response rates and outcomes. In preclinical models, 4-1BB costimulation synergizes with CPIs targeting
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::77571654a67b8230111048825587e8ec
https://doi.org/10.1158/2159-8290.c.6549569
https://doi.org/10.1158/2159-8290.c.6549569