Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Ararat J. Ablooglu"'
Autor:
Bart Weijts, Edgar Gutierrez, Semion K. Saikin, Ararat J. Ablooglu, David Traver, Alex Groisman, Eugene Tkachenko
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-11 (2018)
The mechanisms of sensing of blood flow and responses to it in vascular remodelling are poorly understood. Here, the authors show that in zebrafish blood flow controls both the fate determination of individual blood vessels and the arterial versus ve
Externí odkaz:
https://doaj.org/article/b1794bd622bc45d3a2fefd0e655fefd7
Autor:
Joseph M. Cantor, Ararat J. Ablooglu, Zhongji Liao, Mark H. Ginsberg, Manjula Pandey, Hisashi Kato, Sanford J. Shattil
Publikováno v:
Blood. 125:1995-2004
The bidirectional signaling and hemostatic functions of platelet αIIbβ3 are regulated by kindlin-3 through interactions with the β3 cytoplasmic tail. Little is known about kindlin regulation of the related "vitronectin receptor," αVβ3. These rel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8289eebbbda3f0887b76ac8c567c9023
https://doi.org/10.1182/blood-2014-09-603035
https://doi.org/10.1182/blood-2014-09-603035
Publikováno v:
Journal of Biological Chemistry. 289:11183-11193
Protein-protein interactions are driving forces in cellular processes. As a prime example, transmembrane integrins link extracellular matrix and intracellular proteins, resulting in bidirectional signaling that regulates cell migration, proliferation
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::539b14cdfc5637a39c99bbf91b3b2656
https://doi.org/10.1074/jbc.m113.535369
https://doi.org/10.1074/jbc.m113.535369
Autor:
Alex Groisman, Eugene Tkachenko, Edgar Gutierrez, Semion K. Saikin, Bart Weijts, David Traver, Ararat J. Ablooglu
Arteries and veins are formed independently by different types of endothelial cells (ECs). In vascular remodeling, arteries and veins become connected and some arteries become veins. It is unclear how ECs in transforming vessels change their type and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::af824940cf4127047f7b0177a8736538
https://doi.org/10.1101/095307
https://doi.org/10.1101/095307
Autor:
Rebecca A. Stockton, Mark H. Ginsberg, Andrey A. Bobkov, Ararat J. Ablooglu, Jian J. Liu, Alexandre R. Gingras, Jaewon Han
Publikováno v:
Molecular Biology of the Cell
Rap1 stabilizes cell–cell junctions by directly binding to KRIT1, displacing it from microtubules and enabling localization at the junctions.
Activation of Rap1 small GTPases stabilizes cell–cell junctions, and this activity requires Krev In
Activation of Rap1 small GTPases stabilizes cell–cell junctions, and this activity requires Krev In
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4a959ac97dd459f58ef076dd459025c7
https://doi.org/10.1091/mbc.e11-02-0157
https://doi.org/10.1091/mbc.e11-02-0157
Publikováno v:
Development. 137:3449-3458
Integrin αV can form heterodimers with several β subunits to mediate cell-cell and cell-extracellular matrix interactions. During zebrafish gastrulation, αV is expressed maternally and zygotically. Here, we used a morpholino-mediated αV knockdown
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9cc9a2fcbd58186ea7d40d7e43bda901
https://doi.org/10.1242/dev.045310
https://doi.org/10.1242/dev.045310
Publikováno v:
Developmental Dynamics. 236:2268-2276
alphaVbeta3 is a receptor for vitronectin and other extracellular matrix ligands, and it has been implicated in angiogenesis and osteoclast function in mammals. We have cloned full-length cDNAs of zebrafish integrin alphaV (itgalphaV), and two paralo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::20cb5a4ebfbdba3907602d075f0a4201
https://doi.org/10.1002/dvdy.21229
https://doi.org/10.1002/dvdy.21229
Autor:
Ronald A. Kohanski, John B. Alexander Ross, Mark Frankel, Ararat J. Ablooglu, Elena Rusinova, Robert L. Heinrikson, Joseph W. Leone
Publikováno v:
Molecular and Cellular Biology. 21:4197-4207
Receptor tyrosine kinases may use intrasteric inhibition to suppress autophosphorylation prior to growth factor stimulation. To test this hypothesis we made an Asp1161Ala mutant in the activation loop that relieved intrasteric inhibition of the unpho
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a7bf275f91ef4717d3d882141e10e48b
https://doi.org/10.1128/mcb.21.13.4197-4207.2001
https://doi.org/10.1128/mcb.21.13.4197-4207.2001
Autor:
Mark Frankel, Ararat J. Ablooglu, Stevan R. Hubbard, Ronald A. Kohanski, Steven M. Bishop, Jeffrey H. Till
Publikováno v:
Journal of Biological Chemistry. 276:10049-10055
The tyrosine kinase domain of the insulin receptor is subject to autoinhibition in the unphosphorylated basal state via steric interactions involving the activation loop. A mutation in the activation loop designed to relieve autoinhibition, Asp-1161
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::78d648d4fcf095180d78f0f360665971
https://doi.org/10.1074/jbc.m010161200
https://doi.org/10.1074/jbc.m010161200
Autor:
Jeffrey H. Till, Philip A. Cole, Ararat J. Ablooglu, Keykavous Parang, Ronald A. Kohanski, Stevan R. Hubbard
Publikováno v:
Nature Structural Biology. 8:37-41
Protein kinase inhibitors have applications as anticancer therapeutic agents and biological tools in cell signaling. Based on a phosphoryl transfer mechanism involving a dissociative transition state, a potent and selective bisubstrate inhibitor for
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::aa18f4daad54ad0fccbc8a5be62124eb
https://doi.org/10.1038/83028
https://doi.org/10.1038/83028