Zobrazeno 1 - 10
of 45
pro vyhledávání: '"Aranka Brockmueller"'
Autor:
Alena Mazurakova, Lenka Koklesova, Sandra Hurta Csizmár, Marek Samec, Aranka Brockmueller, Miroslava Šudomová, Kamil Biringer, Erik Kudela, Martin Pec, Samson Mathews Samuel, Monika Kassayova, Sherif T.S. Hassan, Karel Smejkal, Mehdi Shakibaei, Dietrich Büsselberg, Luciano Saso, Peter Kubatka, Olga Golubnitschaja
Publikováno v:
Journal of Advanced Research, Vol 55, Iss , Pp 103-118 (2024)
Background: Cancer management faces multiple obstacles, including resistance to current therapeutic approaches. In the face of challenging microenvironments, cancer cells adapt metabolically to maintain their supply of energy and precursor molecules
Externí odkaz:
https://doaj.org/article/8d1874c70909462aa7839fd64043bac5
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
IntroductionOsteoarthritis (OA) is associated with excessive cartilage degradation, inflammation, and decreased autophagy. Insufficient efficacy of conventional monotherapies and poor tissue regeneration due to side effects are just some of the unres
Externí odkaz:
https://doaj.org/article/67f32f92b9e84d72a86d1e27b38877f1
Publikováno v:
Cells, Vol 13, Iss 13, p 1145 (2024)
Osteoporosis (OP), which is characterized by a decrease in bone density and increased susceptibility to fractures, is closely linked to the gut microbiota (GM). It is increasingly realized that the GM plays a key role in the maintenance of the functi
Externí odkaz:
https://doaj.org/article/5c3e1ddec6404fd3b9e8bd2a3b757cc6
Publikováno v:
Nutrients, Vol 16, Iss 5, p 708 (2024)
Breast cancer (BC) is currently one of the most common cancers in women worldwide with a rising tendency. Epigenetics, generally inherited variations in gene expression that occur independently of changes in DNA sequence, and their disruption could b
Externí odkaz:
https://doaj.org/article/8700497dfc484e918366d10962795cf9
Autor:
Aranka Brockmueller, Sosmitha Girisa, Mahzad Motallebi, Ajaikumar B. Kunnumakkara, Mehdi Shakibaei
Publikováno v:
Frontiers in Pharmacology, Vol 14 (2023)
Background: Hypoxia-inducible factor-1α (HIF-1α) is one of the major tumor-associated transcription factors modulating numerous tumor properties such as tumor cell metabolism, survival, proliferation, angiogenesis, and metastasis. Calebin A (CA), a
Externí odkaz:
https://doaj.org/article/a1b7502684b24dc6a0b39f5e67685600
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
IntroductionP53 represents a key player in apoptosis-induction in cancers including colorectal cancer (CRC) that ranks third worldwide in cancer prevalence as well as mortality statistics. Although a pro-apoptotic effect of resveratrol has been repea
Externí odkaz:
https://doaj.org/article/4de713680a7d4fd2b43d0d3539155a9d
Autor:
Aranka Brockmueller, Anna-Lena Mueller, Ajaikumar B. Kunnumakkara, Bharat B. Aggarwal, Mehdi Shakibaei
Publikováno v:
Frontiers in Oncology, Vol 12 (2022)
Chronic diseases including cancer have high case numbers as well as mortality rates. The efficient treatment of chronic diseases is a major ongoing medical challenge worldwide, because of their complexity and many inflammatory pathways such as JNK, p
Externí odkaz:
https://doaj.org/article/37c7a2395752485da8924353b3c230b6
Publikováno v:
Frontiers in Pharmacology, Vol 13 (2022)
Graphical Abstract
Externí odkaz:
https://doaj.org/article/319bd966c95e4eb997cf75a8508ee96c
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 5, p 4988 (2023)
Frequent development of resistance to chemotherapeutic agents such as 5-flourouracil (5-FU) complicates the treatment of advanced colorectal cancer (CRC). Resveratrol is able to utilize β1-integrin receptors, strongly expressed in CRC cells, to tran
Externí odkaz:
https://doaj.org/article/23e84b1f9d7b46fd8acd28e9fb3c507e
Autor:
Constanze Buhrmann, Aranka Brockmueller, Choudhary Harsha, Ajaikumar B. Kunnumakkara, Peter Kubatka, Bharat B. Aggarwal, Mehdi Shakibaei
Publikováno v:
Frontiers in Pharmacology, Vol 12 (2021)
Background: Tumor microenvironment (TME) has a pivotal impact on tumor progression, and epithelial-mesenchymal transition (EMT) is an extremely crucial initial event in the metastatic process in colorectal cancer (CRC) that is not yet fully understoo
Externí odkaz:
https://doaj.org/article/4f64a298bc2b4e3285b7d21a514f9873