Zobrazeno 1 - 10
of 48
pro vyhledávání: '"Aran F Labrijn"'
Autor:
Henrik J Ditzel, Christa E Müller, Odd L Gammelgaard, Mikkel G Terp, Christian Renn, Aran F Labrijn, Oliver Hamaker, Aaraby Y Nielsen, Henriette Vever, Soren WK Hansen, Morten F Gjerstorff, Paul WHI Parren
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 10, Iss 9 (2022)
Background Immunosuppressive extracellular adenosine is generated by the enzymatic activity of CD73. In preclinical models, antibodies (Abs) targeting different epitopes on CD73 exert anticancer activity through distinct mechanisms such as inhibition
Externí odkaz:
https://doaj.org/article/545f0eb7e81a46de9104ffcb29d1c784
Autor:
Steven W. de Taeye, Arthur E. H. Bentlage, Mirjam M. Mebius, Joyce I. Meesters, Suzanne Lissenberg-Thunnissen, David Falck, Thomas Sénard, Nima Salehi, Manfred Wuhrer, Janine Schuurman, Aran F. Labrijn, Theo Rispens, Gestur Vidarsson
Publikováno v:
Frontiers in Immunology, Vol 11 (2020)
Antibody dependent cellular cytotoxicity (ADCC) is an Fc-dependent effector function of IgG important for anti-viral immunity and anti-tumor therapies. NK-cell mediated ADCC is mainly triggered by IgG-subclasses IgG1 and IgG3 through the IgG-Fc-recep
Externí odkaz:
https://doaj.org/article/7dd572adb41b4228b412bd1779181bed
Autor:
Alicia M Chenoweth, Sandra Esparon, Bruce D Wines, Janine Schuurman, Aran F Labrijn, P Mark Hogarth
Publikováno v:
Immunology & Cell Biology.
Autor:
Thorbald van Hall, Janine Schuurman, J. Sjef Verbeek, Mischa A. Houtkamp, Danita H. Schuurhuis, Aran F. Labrijn, Sandra Verploegen, Marjolein Sluijter, Işıl Altıntaş, Hreinn Benonisson
Dynamics of T cell distribution
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::166bcba5273f3781111e8bfd9926e802
https://doi.org/10.1158/1535-7163.22509997.v1
https://doi.org/10.1158/1535-7163.22509997.v1
Autor:
Thorbald van Hall, Janine Schuurman, J. Sjef Verbeek, Mischa A. Houtkamp, Danita H. Schuurhuis, Aran F. Labrijn, Sandra Verploegen, Marjolein Sluijter, Işıl Altıntaş, Hreinn Benonisson
legends
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7938e70eb122393150fa73261d93df16
https://doi.org/10.1158/1535-7163.22509994.v1
https://doi.org/10.1158/1535-7163.22509994.v1
Autor:
Thorbald van Hall, Janine Schuurman, J. Sjef Verbeek, Mischa A. Houtkamp, Danita H. Schuurhuis, Aran F. Labrijn, Sandra Verploegen, Marjolein Sluijter, Işıl Altıntaş, Hreinn Benonisson
Immunotherapy of cancer with CD3-targeting bispecific antibodies (CD3 bsAb) is a fast developing field, and multiple tumor-associated antigens (TAA) are evaluated for hematologic and solid malignancies. The efficacy of these CD3 bsAb is usually exami
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0d15e11b2ea3ff43ef4500bd633da2e0
https://doi.org/10.1158/1535-7163.c.6539473.v1
https://doi.org/10.1158/1535-7163.c.6539473.v1
Autor:
Odd L Gammelgaard, Mikkel G Terp, Christian Renn, Aran F Labrijn, Oliver Hamaker, Aaraby Y Nielsen, Henriette Vever, Soren WK Hansen, Morten F Gjerstorff, Christa E Müller, Paul WHI Parren, Henrik J Ditzel
Publikováno v:
Journal for ImmunoTherapy of Cancer, 10(9). BMJ PUBLISHING GROUP
BackgroundImmunosuppressive extracellular adenosine is generated by the enzymatic activity of CD73. In preclinical models, antibodies (Abs) targeting different epitopes on CD73 exert anticancer activity through distinct mechanisms such as inhibition
Autor:
Aran F. Labrijn, Thorbald van Hall, Kristel Kemper, Patrick J. Engelberts, Jim Middelburg, Janine Schuurman
Publikováno v:
Cancers, Vol 13, Iss 287, p 287 (2021)
Cancers
Cancers, 13(2). MDPI
Cancers
Cancers, 13(2). MDPI
Simple Summary CD3-bispecific antibody therapy is a form of immunotherapy that enables soldier cells of the immune system to recognize and kill tumor cells. This type of therapy is currently successfully used in the clinic to treat tumors in the bloo
Autor:
Steven J. Orcutt, Aran F. Labrijn, Adam Zwolak, Mark L. Chiu, William M. Atkins, Theo Rispens, Dennis R. Goulet, Rob N. de Jong
Publikováno v:
The Journal of Biological Chemistry
Journal of biological chemistry, 293(2), 651-661. American Society for Biochemistry and Molecular Biology Inc.
Journal of biological chemistry, 293(2), 651-661. American Society for Biochemistry and Molecular Biology Inc.
Bispecific antibodies (bsAbs) combine the antigen specificities of two distinct Abs and demonstrate therapeutic promise based on novel mechanisms of action. Among the many platforms for creating bsAbs, controlled Fab-arm exchange (cFAE) has proven us
Autor:
Anthony A. Armstrong, Tom C. Nesspor, Joyce I. Meesters, Matthew Bunce, Isil Altintas, Sandra Verploegen, Janine Schuurman, Aran F. Labrijn, Sandeep Somani, Mark L. Chiu, Paul W. H. I. Parren
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-14 (2017)
Labrijn, A F, Meesters, J I, Bunce, M, Armstrong, A A, Somani, S, Nesspor, T C, Chiu, M L, Altintaş, I, Verploegen, S, Schuurman, J & Parren, P W H I 2017, ' Efficient Generation of Bispecific Murine Antibodies for Pre-Clinical Investigations in Syngeneic Rodent Models ', Scientific Reports, vol. 7, 2476 . https://doi.org/10.1038/s41598-017-02823-9
Scientific Reports
Labrijn, A F, Meesters, J I, Bunce, M, Armstrong, A A, Somani, S, Nesspor, T C, Chiu, M L, Altintaş, I, Verploegen, S, Schuurman, J & Parren, P W H I 2017, ' Efficient Generation of Bispecific Murine Antibodies for Pre-Clinical Investigations in Syngeneic Rodent Models ', Scientific Reports, vol. 7, 2476 . https://doi.org/10.1038/s41598-017-02823-9
Scientific Reports
Therapeutic concepts exploiting tumor-specific antibodies are often established in pre-clinical xenograft models using immuno-deficient mice. More complex therapeutic paradigms, however, warrant the use of immuno-competent mice, that more accurately