A pathogenic variant in the uncharacterized RNF212B gene results in severe aneuploidy male infertility and repeated IVF failure

Autor: Gershoni, Moran, Braun, Tslil, Hauser, Ron, Barda, Shimi, Lehavi, Ofer, Malcov, Mira, Frumkin, Tsvia, Kalma, Yael, Pietrokovski, Shmuel, Arama, Eli, Kleiman, Sandra E.

Publikováno v: In Human Genetics and Genomics Advances 13 July 2023 4(3)

Apoptotic cell death in disease—Current understanding of the NCCD 2023

Autor: Vitale, Ilio, Pietrocola, Federico, Guilbaud, Emma, Aaronson, Stuart A, Abrams, John M, Adam, Dieter, Agostini, Massimiliano, Agostinis, Patrizia, Alnemri, Emad S, Altucci, Lucia, Amelio, Ivano, Andrews, David W, Aqeilan, Rami I, Arama, Eli, Baehrecke, Eric H, Balachandran, Siddharth, Bano, Daniele, Barlev, Nickolai A, Bartek, Jiri, Bazan, Nicolas G, Becker, Christoph, Bernassola, Francesca, Bertrand, Mathieu J M, Bianchi, Marco E, Blagosklonny, Mikhail V, Blander, J Magarian, Blandino, Giovanni, Blomgren, Klas, Borner, Christoph, Bortner, Carl D, Bove, Pierluigi, Boya, Patricia, Brenner, Catherine, Broz, Petr, Brunner, Thomas, Damgaard, Rune Busk, Calin, George A, Campanella, Michelangelo, Candi, Eleonora, Carbone, Michele, Carmona-Gutierrez, Didac, Cecconi, Francesco, Chan, Francis K-M, Chen, Guo-Qiang, Chen, Quan, Chen, Youhai H, Cheng, Emily H, Chipuk, Jerry E, Cidlowski, John A, Ciechanover, Aaron, Ciliberto, Gennaro, Conrad, Marcus, Cubillos-Ruiz, Juan R, Czabotar, Peter E, D'Angiolella, Vincenzo, Daugaard, Mads, Dawson, Ted M, Dawson, Valina L, De Maria, Ruggero, De Strooper, Bart, Debatin, Klaus-Michael, Deberardinis, Ralph J, Degterev, Alexei, Del Sal, Giannino, Deshmukh, Mohanish, Di Virgilio, Francesco, Diederich, Marc, Dixon, Scott J, Dynlacht, Brian D, El-Deiry, Wafik S, Elrod, John W, Engeland, Kurt, Fimia, Gian Maria, Galassi, Claudia, Ganini, Carlo, Garcia-Saez, Ana J, Garg, Abhishek D, Garrido, Carmen, Gavathiotis, Evripidis, Gerlic, Motti, Ghosh, Sourav, Green, Douglas R, Greene, Lloyd A, Gronemeyer, Hinrich, Häcker, Georg, Hajnóczky, György, Hardwick, J Marie, Haupt, Ygal, He, Sudan, Heery, David M, Hengartner, Michael O, Hetz, Claudio, Hildeman, David A, Ichijo, Hidenori, Inoue, Satoshi, Jäättelä, Marja, Janic, Ana, Joseph, Bertrand, Jost, Philipp J, Kanneganti, Thirumala-Devi, Karin, Michael, Kashkar, Hamid, Kaufmann, Thomas, Kelly, Gemma L, Kepp, Oliver, Kimchi, Adi, Kitsis, Richard N, Klionsky, Daniel J, Kluck, Ruth, Krysko, Dmitri V, Kulms, Dagmar, Kumar, Sharad, Lavandero, Sergio, Lavrik, Inna N, Lemasters, John J, Liccardi, Gianmaria, Linkermann, Andreas, Lipton, Stuart A, Lockshin, Richard A, López-Otín, Carlos, Luedde, Tom, MacFarlane, Marion, Madeo, Frank, Malorni, Walter, Manic, Gwenola, Mantovani, Roberto, Marchi, Saverio, Marine, Jean-Christophe, Martin, Seamus J, Martinou, Jean-Claude, Mastroberardino, Pier G, Medema, Jan Paul, Mehlen, Patrick, Meier, Pascal, Melino, Gerry, Melino, Sonia, Miao, Edward A, Moll, Ute M, Muñoz-Pinedo, Cristina, Murphy, Daniel J, Niklison-Chirou, Maria Victoria, Novelli, Flavia, Núñez, Gabriel, Oberst, Andrew, Ofengeim, Dimitry, Opferman, Joseph T, Oren, Moshe, Pagano, Michele, Panaretakis, Theocharis, Pasparakis, Manolis, Penninger, Josef M, Pentimalli, Francesca, Pereira, David M, Pervaiz, Shazib, Peter, Marcus E, Pinton, Paolo, Porta, Giovanni, Prehn, Jochen H M, Puthalakath, Hamsa, Rabinovich, Gabriel A, Rajalingam, Krishnaraj, Ravichandran, Kodi S, Rehm, Markus, Ricci, Jean-Ehrland, Rizzuto, Rosario, Robinson, Nirmal, Rodrigues, Cecilia M P, Rotblat, Barak, Rothlin, Carla V, Rubinsztein, David C, Rudel, Thomas, Rufini, Alessandro, Ryan, Kevin M, Sarosiek, Kristopher A, Sawa, Akira, Sayan, Emre, Schroder, Kate, Scorrano, Luca, Sesti, Federico, Shao, Feng, Shi, Yufang, Sica, Giuseppe S, Silke, John, Simon, Hans-Uwe, Sistigu, Antonella, Stephanou, Anastasis, Stockwell, Brent R, Strapazzon, Flavie, Strasser, Andreas, Sun, Liming, Sun, Erwei, Sun, Qiang, Szabadkai, Gyorgy, Tait, Stephen W G, Tang, Daolin, Tavernarakis, Nektarios, Troy, Carol M, Turk, Boris, Urbano, Nicoletta, Vandenabeele, Peter, Vanden Berghe, Tom, Vander Heiden, Matthew G, Vanderluit, Jacqueline L, Verkhratsky, Alexei, Villunger, Andreas, von Karstedt, Silvia, Voss, Anne K, Vousden, Karen H, Vucic, Domagoj, Vuri, Daniela, Wagner, Erwin F, Walczak, Henning, Wallach, David, Wang, Ruoning, Wang, Ying, Weber, Achim, Wood, Will, Yamazaki, Takahiro, Yang, Huang-Tian, Zakeri, Zahra, Zawacka-Pankau, Joanna E, Zhang, Lin, Zhang, Haibing, Zhivotovsky, Boris, Zhou, Wenzhao, Piacentini, Mauro, Kroemer, Guido, Galluzzi, Lorenzo

Publikováno v: Vitale, I, Pietrocola, F, Guilbaud, E, Aaronson, S A, Abrams, J M, Adam, D, Agostini, M, Agostinis, P, Alnemri, E S, Altucci, L, Amelio, I, Andrews, D W, Aqeilan, R I, Arama, E, Baehrecke, E H, Balachandran, S, Bano, D, Barlev, N A, Bartek, J, Bazan, N G, Becker, C, Bernassola, F, Bertrand, M J M, Bianchi, M E, Blagosklonny, M V, Blander, J M, Blandino, G, Blomgren, K, Borner, C, Bortner, C D, Bove, P, Boya, P, Brenner, C, Broz, P, Brunner, T, Damgaard, R B, Calin, G A, Campanella, M, Candi, E, Carbone, M, Carmona-Gutierrez, D, Cecconi, F, Chan, F K M, Chen, G Q, Chen, Q, Chen, Y H, Cheng, E H, Chipuk, J E, Cidlowski, J A, Ciechanover, A, Ciliberto, G, Conrad, M, Cubillos-Ruiz, J R, Czabotar, P E, D’Angiolella, V, Daugaard, M, Dawson, T M, Dawson, V L, De Maria, R, De Strooper, B, Debatin, K M, Deberardinis, R J, Degterev, A, Del Sal, G, Deshmukh, M, Di Virgilio, F, Diederich, M, Dixon, S J, Dynlacht, B D, El-Deiry, W S, Elrod, J W, Engeland, K, Fimia, G M, Galassi, C, Ganini, C, Garcia-Saez, A J, Garg, A D, Garrido, C, Gavathiotis, E, Gerlic, M, Ghosh, S, Green, D R, Greene, L A, Gronemeyer, H, Häcker, G, Hajnóczky, G, Hardwick, J M, Haupt, Y, He, S, Heery, D M, Hengartner, M O, Hetz, C, Hildeman, D A, Ichijo, H, Inoue, S, Jäättelä, M, Janic, A, Joseph, B, Jost, P J, Kanneganti, T D, Karin, M, Kashkar, H, Kaufmann, T, Kelly, G L, Kepp, O, Kimchi, A, Kitsis, R N, Klionsky, D J, Kluck, R, Krysko, D V, Kulms, D, Kumar, S, Lavandero, S, Lavrik, I N, Lemasters, J J, Liccardi, G, Linkermann, A, Lipton, S A, Lockshin, R A, López-Otín, C, Luedde, T, MacFarlane, M, Madeo, F, Malorni, W, Manic, G, Mantovani, R, Marchi, S, Marine, J C, Martin, S J, Martinou, J C, Mastroberardino, P G, Medema, J P, Mehlen, P, Meier, P, Melino, G, Melino, S, Miao, E A, Moll, U M, Muñoz-Pinedo, C, Murphy, D J, Niklison-Chirou, M V, Novelli, F, Núñez, G, Oberst, A, Ofengeim, D, Opferman, J T, Oren, M, Pagano, M, Panaretakis, T, Pasparakis, M, Penninger, J M, Pentimalli, F, Pereira, D M, Pervaiz, S, Peter, M E, Pinton, P, Porta, G, Prehn, J H M, Puthalakath, H, Rabinovich, G A, Rajalingam, K, Ravichandran, K S, Rehm, M, Ricci, J E, Rizzuto, R, Robinson, N, Rodrigues, C M P, Rotblat, B, Rothlin, C V, Rubinsztein, D C, Rudel, T, Rufini, A, Ryan, K M, Sarosiek, K A, Sawa, A, Sayan, E, Schroder, K, Scorrano, L, Sesti, F, Shao, F, Shi, Y, Sica, G S, Silke, J, Simon, H U, Sistigu, A, Stephanou, A, Stockwell, B R, Strapazzon, F, Strasser, A, Sun, L, Sun, E, Sun, Q, Szabadkai, G, Tait, S W G, Tang, D, Tavernarakis, N, Troy, C M, Turk, B, Urbano, N, Vandenabeele, P, Vanden Berghe, T, Vander Heiden, M G, Vanderluit, J L, Verkhratsky, A, Villunger, A, von Karstedt, S, Voss, A K, Vousden, K H, Vucic, D, Vuri, D, Wagner, E F, Walczak, H, Wallach, D, Wang, R, Wang, Y, Weber, A, Wood, W, Yamazaki, T, Yang, H T, Zakeri, Z, Zawacka-Pankau, J E, Zhang, L, Zhang, H, Zhivotovsky, B, Zhou, W, Piacentini, M, Kroemer, G & Galluzzi, L 2023, ' Apoptotic cell death in disease—Current understanding of the NCCD 2023 ', Cell Death and Differentiation, vol. 30, no. 5, pp. 1097-1154 . https://doi.org/10.1038/s41418-023-01153-w
Cell death and differentiation 30(5), 1097-1154 (2023). doi:10.1038/s41418-023-01153-w

58 p.-5 fig.-7 box.
Apoptosis is a form of regulated cell death (RCD) that involves proteases of the caspase family. Pharmacological and genetic strategies that experimentally inhibit or delay apoptosis in mammalian systems have elucidated the k

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ab2b742266215ffe65e96dc332753aba
https://orbit.dtu.dk/en/publications/0f60f683-cf55-4ff1-9d52-631620c6ad87

Non‐lethal message from the Holy Land: The first international conference on nonapoptotic roles of apoptotic proteins.

Autor: Arama, Eli¹ (AUTHOR) eli.arama@weizmann.ac.il, Baena‐Lopez, Luis Alberto² (AUTHOR), Fearnhead, Howard O.³ (AUTHOR)

Publikováno v: FEBS Journal. Apr2021, Vol. 288 Issue 7, p2166-2183. 18p.

Controlling caspase activity in life and death.

Autor: White, Kristin¹, Arama, Eli², Hardwick, J. Marie³ hardwick@jhu.edu

Publikováno v: PLoS Genetics. 2/16/2017, Vol. 13 Issue 2, p1-6. 6p.

p53-dependent programmed necrosis controls germ cell homeostasis during spermatogenesis

Autor: Napoletano, Francesco, Gibert, Benjamin, Yacobi-Sharon, Keren, Vincent, Stéphane, Favrot, Clémentine, Mehlen, Patrick, Girard, Victor, Teil, Margaux, Chatelain, Gilles, Walter, Ludivine, Arama, Eli, Mollereau, Bertrand

Publikováno v: PLoS Genetics
PLoS Genetics, Public Library of Science, 2017, 13 (9), pp.e1007024. ⟨10.1371/journal.pgen.1007024⟩
PLoS Genetics, 2017, 13 (9), pp.e1007024. ⟨10.1371/journal.pgen.1007024⟩
PLoS Genetics, Vol 13, Iss 9, p e1007024 (2017)

The importance of regulated necrosis in pathologies such as cerebral stroke and myocardial infarction is now fully recognized. However, the physiological relevance of regulated necrosis remains unclear. Here, we report a conserved role for p53 in reg

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::474017ff0f415aa09aa163090e06434b
https://hal.archives-ouvertes.fr/hal-02377207