Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Aram Lyu"'
Autor:
Aram Lyu, Ryan S. Humphrey, Seo Hee Nam, Tyler A. Durham, Zicheng Hu, Dhivya Arasappan, Terzah M. Horton, Lauren I. R. Ehrlich
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-17 (2023)
Abstract We previously found that T-cell acute lymphoblastic leukemia (T-ALL) requires support from tumor-associated myeloid cells, which activate Insulin Like Growth Factor 1 Receptor (IGF1R) signaling in leukemic blasts. However, IGF1 is not suffic
Externí odkaz:
https://doaj.org/article/e9fb44485b3149c89cdbcadcd98daf4d
Autor:
Lawrence Fong, Eliezer Van Allen, Alec Starzinski, Zenghua Fan, Diamond Luong, Aram Lyu, Ali Setayesh
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 11, Iss Suppl 1 (2023)
Externí odkaz:
https://doaj.org/article/e6d91c42de714cc091858a4b57e001ad
Autor:
George Georgiou, Seo Hee Nam, Aram Lyu, Hilary J. Selden, Chang-Han Lee, Wesley H. Godfrey, Lauren I.R. Ehrlich, Adviti Sarang, Todd A. Triplett, Dhivya Arasappan, Terzah M. Horton, Rachel Y. Ames, Zicheng Hu
Publikováno v:
Blood. 136:1837-1850
Despite harboring mutations in oncogenes and tumor suppressors that promote cancer growth, T-cell acute lymphoblastic leukemia (T-ALL) cells require exogenous cells or signals to survive in culture. We previously reported that myeloid cells, particul
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4b8746cfd2b9313a83ccd0b6e8f4d9e9
https://doi.org/10.1182/blood.2020007145
https://doi.org/10.1182/blood.2020007145
Autor:
Aram Lyu, Seo Hee Nam, Ryan S. Humphrey, Tyler A. Durham, Zicheng Hu, Dhivya Arasappan, Terzah M. Horton, Lauren I. R. Ehrlich
We previously found that T-cell acute lymphoblastic leukemia (T-ALL) requires support from tumor-associated myeloid cells, which activate IGF1R signaling in the leukemic blasts. However, IGF1 is not sufficient to sustain T-ALL survival in vitro, impl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d272c8bb77114a0b0d01a581c5374ed5
https://doi.org/10.1101/2022.01.05.475106
https://doi.org/10.1101/2022.01.05.475106
Autor:
Sonia Mason, Emily K. Grantham, Moatasem M. Azzam, Yuri A. Blednov, R. Adron Harris, Anna S. Warden, Lauren I.R. Ehrlich, Aram Lyu, Adriana DaCosta, Todd A. Triplett, R. Dayne Mayfield
Publikováno v:
Addict Biol
Alcohol abuse induces changes in microglia morphology and immune function, but whether microglia initiate or simply amplify the harmful effects of alcohol exposure is still a matter of debate. Here, we determine microglia function in acute and volunt
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4b3f5344f930d8123593a97bc685ed1c
https://doi.org/10.1111/adb.12889
https://doi.org/10.1111/adb.12889
Publikováno v:
Cancer Research. 81:3185-3185
T-cell acute lymphoblastic leukemia (T-ALL) is a malignant transformation of immature T cells. Although T-ALL harbors multiple pro-leukemic genetic alterations, T-ALL blasts require exogenous signals to survive. We recently reported that tumor-associ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::09d42723e916b44037e1505a0bfcd641
https://doi.org/10.1158/1538-7445.am2021-3185
https://doi.org/10.1158/1538-7445.am2021-3185
Autor:
Aram Lyu, Todd A. Triplett, Wesley H. Godfrey, Seo Hee Nam, Rachel Y. Ames, Zicheng Hu, Adviti Sarang, Hilary J. Selden, Chang-Han Lee, George Georgiou, Terzah M. Horton, Lauren I. R. Ehrlich
Publikováno v:
The Journal of Immunology. 204:163.5-163.5
T cell acute lymphoblastic leukemia (T-ALL) is a malignancy of immature T cells. Despite harboring multiple genetic alterations that drive disease, primary T-ALL cells require exogenous signals to survive. We previously reported that tumor-associated
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b8aeeda11ba7ce6ff83f5a86d9bb89f5
https://doi.org/10.4049/jimmunol.204.supp.163.5
https://doi.org/10.4049/jimmunol.204.supp.163.5
Publikováno v:
The Journal of Immunology. 200:56.6-56.6
T cell acute lymphoblastic leukemia (T-ALL) is a malignancy of developing T cells. Although intensified radiation and chemotherapy have improved survival rates to ~85% in pediatric patients, these therapies are toxic, and patients who relapse have no
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::167e458fbd352dc3953dcced6fb86d2b
https://doi.org/10.4049/jimmunol.200.supp.56.6
https://doi.org/10.4049/jimmunol.200.supp.56.6
Publikováno v:
Cancer Research. 77:2965-2965
T cell acute lymphoblastic leukemia (T-ALL) is a hematological cancer that arises from developing T-cells. Most T-ALL research has focused on elucidating cell-intrinsic genetic permutations that promote tumor proliferation and survival, which has res
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::62c063323a5cdcd3fad0b5b6565b1169
https://doi.org/10.1158/1538-7445.am2017-2965
https://doi.org/10.1158/1538-7445.am2017-2965
Publikováno v:
Plantcell physiology. 51(10)
Genes that are stably expressed during development or in response to environmental changes are essential for accurate normalization in qRT-PCR experiments. To prevent possible misinterpretation caused by the use of unstable housekeeping genes, such a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bb0b5a7c14e9cec208d37529e980725c
https://pubmed.ncbi.nlm.nih.gov/20798276
https://pubmed.ncbi.nlm.nih.gov/20798276