Zobrazeno 1 - 10
of 27
pro vyhledávání: '"Aram Davtyan"'
Autor:
Arpine Poghosyan, Sona Hakobyan, Hranush Avagyan, Aida Avetisyan, Nane Bayramyan, Lina Hakobyan, Liana Abroyan, Aram Davtyan, Davit Poghosyan, Bagrat Baghdasaryan, Elina Arakelova, Elena Karalova, Zaven Karalyan
Publikováno v:
Virology Journal, Vol 21, Iss 1, Pp 1-13 (2024)
Abstract The spread of the African swine fever virus (ASF virus) genotype ii in the Eurasian region has been very successful and often inexplicable. The virus spreads rapidly and persists in areas with wild boar populations, but areas without feral p
Externí odkaz:
https://doaj.org/article/a2616c1143374ebbad0440a54298d583
Publikováno v:
Frontiers in Oncology, Vol 13 (2023)
IntroductionThe p53-Y220C mutation is one of the most common mutations that play a major role in cancer progression.MethodsIn this study, we applied artificial intelligence (AI)-powered virtual screening to identify small-molecule compounds that spec
Externí odkaz:
https://doaj.org/article/87cc42fb452445c99a637c523a586f15
Autor:
Artur Meller, Saulo De Oliveira, Aram Davtyan, Tigran Abramyan, Gregory R. Bowman, Henry van den Bedem
Publikováno v:
Frontiers in Molecular Biosciences, Vol 10 (2023)
Virtual screening is a widely used tool for drug discovery, but its predictive power can vary dramatically depending on how much structural data is available. In the best case, crystal structures of a ligand-bound protein can help find more potent li
Externí odkaz:
https://doaj.org/article/b60074420ce54bbd8559ec679949561f
Autor:
Wei Lu, Carlos Bueno, Nicholas P Schafer, Joshua Moller, Shikai Jin, Xun Chen, Mingchen Chen, Xinyu Gu, Aram Davtyan, Juan J de Pablo, Peter G Wolynes
Publikováno v:
PLoS Computational Biology, Vol 17, Iss 2, p e1008308 (2021)
We present OpenAWSEM and Open3SPN2, new cross-compatible implementations of coarse-grained models for protein (AWSEM) and DNA (3SPN2) molecular dynamics simulations within the OpenMM framework. These new implementations retain the chemical accuracy a
Externí odkaz:
https://doaj.org/article/0798f893f15a4c1cbfc88bfc6b07fa78
Autor:
Aram Davtyan, Paolo Favaro
Publikováno v:
Lecture Notes in Computer Science ISBN: 9783031197895
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1b4aa5f2c7969bc17b9975eb517f441f
https://doi.org/10.1007/978-3-031-19790-1_5
https://doi.org/10.1007/978-3-031-19790-1_5
Publikováno v:
Proceedings of the National Academy of Sciences. 117:1468-1477
Assemblies of structural maintenance of chromosomes (SMC) proteins and kleisin subunits are essential to chromosome organization and segregation across all kingdoms of life. While structural data exist for parts of the SMC−kleisin complexes, comple
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f178cbbdc4de04b61588be64c21a9862
https://doi.org/10.1073/pnas.1917750117
https://doi.org/10.1073/pnas.1917750117
Autor:
Aram Davtyan, Peter G. Wolynes, Peter G. Vekilov, Nicholas P. Schafer, Yuechuan Xu, Kaitlin Knapp, Kyle N Le, Mohammad S. Safari
Publikováno v:
Proc Natl Acad Sci U S A
Amyloid fibrillization is an exceedingly complex process in which incoming peptide chains bind to the fibril while concertedly folding. The coupling between folding and binding is not fully understood. We explore the molecular pathways of association
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3376ad6becb4721ddf2fa35b14934d30
https://doi.org/10.1073/pnas.2110995118
https://doi.org/10.1073/pnas.2110995118
Autor:
Arash Saeedi, Mohsen Fathi, Michelle Craig Barton, Alena Klindziuk, Michael B. Sherman, David S. Yang, Navin Varadarajan, Peter G. Vekilov, Aram Davtyan, Anatoly B. Kolomeisky, Mohammad S. Safari
Publikováno v:
Proc Natl Acad Sci U S A
The protein p53 is a crucial tumor suppressor, often called "the guardian of the genome"; however, mutations transform p53 into a powerful cancer promoter. The oncogenic capacity of mutant p53 has been ascribed to enhanced propensity to fibrillize an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::01be2f28c0f64d8ff02e6e4d94e0cef3
https://doi.org/10.1073/pnas.2015618118
https://doi.org/10.1073/pnas.2015618118
Autor:
Raheleh Roudi, Yong Li, Dana Rae Tardiel-Cyril, Daniele Generali, Navid Sobhani, Aram Davtyan
Publikováno v:
Cancers
Cancers, Vol 13, Iss 1440, p 1440 (2021)
Cancers, Vol 13, Iss 1440, p 1440 (2021)
Simple Summary In the fight against cancer, immunotherapies have given great hope after encouraging results in clinical investigations showing complete remission in some patients with melanoma. In fact, directing the immune system against cancer has
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3f5132183bdd488df2268125ec88e20c
https://doi.org/10.20944/preprints202102.0150.v1
https://doi.org/10.20944/preprints202102.0150.v1
Autor:
Shikai Jin, Carlos Bueno, Peter G. Wolynes, Aram Davtyan, Wei Lu, Mingchen Chen, Nicholas P. Schafer, Xinyu Gu, Xun Chen, Juan J. de Pablo, Joshua Moller
Publikováno v:
PLoS Computational Biology, Vol 17, Iss 2, p e1008308 (2021)
PLoS Computational Biology
PLoS Computational Biology
We present OpenAWSEM and Open3SPN2, new cross-compatible implementations of coarse-grained models for protein (AWSEM) and DNA (3SPN2) molecular dynamics simulations within the OpenMM framework. These new implementations retain the chemical accuracy a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::16ea4e7c9b5a38b9e36931dd9ae0b008
https://doaj.org/article/0798f893f15a4c1cbfc88bfc6b07fa78
https://doaj.org/article/0798f893f15a4c1cbfc88bfc6b07fa78