Zobrazeno 1 - 10
of 23
pro vyhledávání: '"Arafath Kaja, Najumudeen"'
Publikováno v:
European Journal of Cell Biology, Vol 102, Iss 2, Pp 151314- (2023)
The small GTPase Ras is frequently mutated in cancer and a driver of tumorigenesis. The recent years have shown great progress in drug-targeting Ras and understanding how it operates on the plasma membrane. We now know that Ras is non-randomly organi
Externí odkaz:
https://doaj.org/article/ffd7ea454cd94434b1090fcb4a1ab995
Autor:
Owen J. Sansom, John R. P. Knight, Simon T. Barry, Rachel A. Ridgway, David Sumpton, Rory T. Steven, Giovanny Rodriguez-Blanco, Eyal Gottlieb, Gaurav Malviya, William C. Clark, Douglas Strathdee, Emma R. Johnson, Holly Hall, Alex Dexter, Teresa Murta, David Y. Lewis, Saverio Tardito, Gregory Hamm, Gavin Brown, Colin Nixon, Kathryn Gilroy, Zoltan Takats, Sudhir B Malla, Dmitry Solovyev, Sigrid K. Fey, Fatih Ceteci, Gillian M. Mackay, Susan E. Critchlow, Ann Hedley, Nikola Vlahov, Alan M. Race, Martin Bushell, Andrew D. Campbell, Arafath Kaja Najumudeen, Richard J. A. Goodwin, Josephine Bunch, Chelsea J. Nikula, Agata Mrowinska, Philip D Dunne, Rene Jackstadt, Joshua D.G. Leach
Publikováno v:
Nature Genetics. 53:16-26
Oncogenic KRAS mutations and inactivation of the APC tumor suppressor co-occur in colorectal cancer (CRC). Despite efforts to target mutant KRAS directly, most therapeutic approaches focus on downstream pathways, albeit with limited efficacy. Moreove
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::75b377e356fc13ecf01a28f7768fd651
https://doi.org/10.1038/s41588-020-00753-3
https://doi.org/10.1038/s41588-020-00753-3
Autor:
Jim Cassidy, Owen J. Sansom, William C. Clark, Luis Serrano, Volker M. Stucke, Martin J Drysdale, Martin R Turner, Arafath Kaja Najumudeen, R.P. Fordham, Karen Pickering, Lucas B. Zeiger, Ewan J. McGhee, Saskia M. Brachmann, Ann Hedley, Andrew D. Campbell, Kathryn Gilroy, Jeanette A. Johansson, Maureen M. Bain, David F. Vincent, Kevin Myant, Christina Kiel, Kurt I. Anderson, Benjamin LeRoy Miller, Angeliki Malliri, S.R. van Hoof, Sigrid K. Fey, Jan Paul Medema, E.B. Unal, Anna-Karin E. Johnsson, Catherine Nixon, Laura M. Machesky, Douglas Strathdee
Publikováno v:
Nature communications, 12(1):56. Nature Publishing Group
Nature Communications
Pickering, KA, Gilroy, K, Cassidy, JW, Fey, SK, Najumudeen, AK, Zeiger, LB, Vincent, DF, Gay, DM, Johansson, J, Fordham, RP, Miller, B, Clark, W, Hedley, A, Unal, EB, Kiel, C, McGhee, E, Macheskey, LM, Nixon, C, Johnsson, AE, Bain, M, Strathdee, D, van Hoof, SR, Medema, JP, Anderson, KI, Brachmann, SM, Stucke, VM, Malliri, A, Drysdale, M, Turner, M, Serrano, L, Myant, K B, Campbell, AD & Sansom, OJ 2021, ' A RAC-GEF network critical for early intestinal tumourigenesis ', Nature Communications . https://doi.org/10.1038/s41467-020-20255-4
Nature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
University of Edinburgh-PURE
Nature Communications
Pickering, KA, Gilroy, K, Cassidy, JW, Fey, SK, Najumudeen, AK, Zeiger, LB, Vincent, DF, Gay, DM, Johansson, J, Fordham, RP, Miller, B, Clark, W, Hedley, A, Unal, EB, Kiel, C, McGhee, E, Macheskey, LM, Nixon, C, Johnsson, AE, Bain, M, Strathdee, D, van Hoof, SR, Medema, JP, Anderson, KI, Brachmann, SM, Stucke, VM, Malliri, A, Drysdale, M, Turner, M, Serrano, L, Myant, K B, Campbell, AD & Sansom, OJ 2021, ' A RAC-GEF network critical for early intestinal tumourigenesis ', Nature Communications . https://doi.org/10.1038/s41467-020-20255-4
Nature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
University of Edinburgh-PURE
RAC1 activity is critical for intestinal homeostasis, and is required for hyperproliferation driven by loss of the tumour suppressor gene Apc in the murine intestine. To avoid the impact of direct targeting upon homeostasis, we reasoned that indirect
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d4a4588ea791829c408931197ab3e425
https://pure.amc.nl/en/publications/a-racgef-network-critical-for-early-intestinal-tumourigenesis(1d3b7cc2-5483-46a6-accd-e659022a288b).html
https://pure.amc.nl/en/publications/a-racgef-network-critical-for-early-intestinal-tumourigenesis(1d3b7cc2-5483-46a6-accd-e659022a288b).html
Publikováno v:
PLoS ONE, Vol 9, Iss 1 (2014)
Externí odkaz:
https://doaj.org/article/f9764661da97459abe091a943bdaea06
Autor:
Pirjo Nummela, Colin Nixon, William C. Clark, Ella Gilchrist, Simon J. Leedham, Michael C. Hodder, Nalle Pentinmikko, Arafath Kaja Najumudeen, Nathalie Sphyris, E. Yvonne Jones, Jean-Paul Vincent, Hans Clevers, Nicky J. Willis, Alexander Raven, Kristina Kirschner, Dustin J. Flanagan, Paul V. Fish, Emma Minnee, Pekka Katajisto, Ville Hietakangas, Owen J. Sansom, Christine Perret, Lynn McGarry, Nadia Nasreddin, Rachel A. Ridgway, Ann C. Williams, Kathryn Gilroy, Kalle Luopajärvi, Sandra Scharaw, Béatrice Romagnolo, Marianne Lähde, Ari Ristimäki, Johanna Englund, Anna Taylor Webb, Kari Alitalo, Ann Hedley
Publikováno v:
Nature, 594(7863), 430-435. Nature Publishing Group
Flanagan, D J, Williams, A C, Katajisto, P K, Sampson, O J & al., E 2021, ' NOTUM from Apc-mutant cells biases clonal competition to initiate cancer ', Nature, vol. 594, pp. 430–435 (2021) . https://doi.org/10.1038/s41586-021-03525-z
Flanagan, D J, Williams, A C, Katajisto, P K, Sampson, O J & al., E 2021, ' NOTUM from Apc-mutant cells biases clonal competition to initiate cancer ', Nature, vol. 594, pp. 430–435 (2021) . https://doi.org/10.1038/s41586-021-03525-z
Funding Information: Acknowledgements We thank the Core Services and Advanced Technologies at the Cancer Research UK Beatson Institute (C596/A17196 and A31287), and particularly the Biological Services Unit, Histology Service and Molecular Technologi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d5733edf6d5fc44fd62aea7978eb694e
https://pure.knaw.nl/portal/en/publications/69a3582f-fc29-4f40-bc5f-17ba7825a11a
https://pure.knaw.nl/portal/en/publications/69a3582f-fc29-4f40-bc5f-17ba7825a11a
Autor:
Anne E. Willis, Laura McDonald, George Skalka, Andrew D. Campbell, Heather McKinnon, Kevin M. Haigis, John R. P. Knight, Sebastian May-Wilson, Kathryn Gilroy, William J. Faller, Emma Stanway, Leah Officer, Rachael C. L. Smith, Joshua D.G. Leach, Joseph A. Waldron, Rachel A. Ridgway, Nicola Valeri, Ewan M. Smith, Arafath Kaja Najumudeen, Nahum Sonenberg, Joanne Edwards, Rene Jackstadt, Ana Teodósio, John Le Quesne, Dustin J. Flanagan, Anne Cheasty, Georgios Kanellos, Kerri McArthur, Christopher G. Proud, Constantinos Alexandrou, Georgios Vlachogiannis, Neil P. Jones, Nikola Vlahov, Owen J. Sansom, Kathryn Af Pennel, Craig MacKay, Martin E. Swarbrick, Martin Bushell
Publikováno v:
Knight, J R P, Alexandrou, C, Skalka, G L, Vlahov, N, Pennel, K, Officer, L, Teodosio, A, Kanellos, G, Gay, D M, May-Wilson, S, Smith, E M, Najumudeen, A K, Gilroy, K, Ridgway, R A, Flanagan, D J, Smith, R C L, McDonald, L, MacKay, C, Cheasty, A, McArthur, K, Stanway, E, Leach, J D, Jackstadt, R, Waldron, J A, Campbell, A D, Vlachogiannis, G, Valeri, N, Haigis, K M, Sonenberg, N, Proud, C G, Jones, N P, Swarbrick, M E, McKinnon, H J, Faller, W J, Quesne, J L, Edwards, J, Willis, A E, Bushell, M & Sansom, O J 2021, ' MNK Inhibition Sensitizes KRAS-Mutant Colorectal Cancer to mTORC1 Inhibition by Reducing eIF4E Phosphorylation and c-MYC Expression ', Cancer discovery, vol. 11, no. 5, pp. 1228-1247 . https://doi.org/10.1158/2159-8290.CD-20-0652
KRAS-mutant colorectal cancers are resistant to therapeutics, presenting a significant problem for ∼40% of cases. Rapalogs, which inhibit mTORC1 and thus protein synthesis, are significantly less potent in KRAS-mutant colorectal cancer. Using Kras-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a4b093ca20383c7ab94bac414895dbf3
https://doi.org/10.1158/2159-8290.CD-20-0652
https://doi.org/10.1158/2159-8290.CD-20-0652
Autor:
Mert Erkan, Julia Lee, Marina Pajic, Janet Youkhana, Anouschka Akerman, Nelson Russia, Amber L. Johns, Thomas P. Davis, Thomas R. Cox, Jie Liu, Jessica L. Chitty, Rosa Mistica C. Ignacio, Angela Chou, George Sharbeen, Yordanos F I Setargew, Yi Fang Guan, Andrew D. Campbell, Joshua A. McCarroll, Jeff Holst, Jennifer P. Morton, Nigel Turner, Arafath Kaja Najumudeen, Koroush S. Haghighi, Estrella Gonzales-Aloy, Phoebe A. Phillips, Owen J. Sansom, Paul Timpson, Val Gebski, Chantal Kopecky, Sigrid K. Fey, Minoti V. Apte, Cyrille Boyer, Brooke A. Pereira, David Goldstein, Stephanie Naim, John Kokkinos, Anthony J. Gill, Jorjina Kasparian, Benjamin J McLean
Publikováno v:
Cancer Research
Cancer-associated fibroblasts (CAF) are major contributors to pancreatic ductal adenocarcinoma (PDAC) progression through protumor signaling and the generation of fibrosis, the latter of which creates a physical barrier to drugs. CAF inhibition is th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3ef2f04e3bd86332b0646ae479e3af1f
http://cdm21054.contentdm.oclc.org/cdm/ref/collection/IR/id/10025
http://cdm21054.contentdm.oclc.org/cdm/ref/collection/IR/id/10025
Publikováno v:
PLoS ONE, Vol 8, Iss 6, p e66425 (2013)
Hundreds of eukaryotic signaling proteins require myristoylation to functionally associate with intracellular membranes. N-myristoyl transferases (NMT) responsible for this modification are established drug targets in cancer and infectious diseases.
Externí odkaz:
https://doaj.org/article/85cd1ded5fa44cfeadbc2fb9b2a0096a
Autor:
Ian S. Gilmore, Piotr Grabowski, Mariia Yuneva, Arafath Kaja Najumudeen, Bin Yan, Panina Y, Teresa Murta, Andrew D. Campbell, Chelsea J. Nikula, Simon T. Barry, Alex Dexter, Owen J. Sansom, Kenneth N. Robinson, Richard J. A. Goodwin, Josephine Bunch, Spencer A. Thomas, John G. Swales, Adam J. Taylor, Zoltan Takats, Efstathios A Elia, Gregory Hamm, Rory T. Steven
High dimensionality omics and hyperspectral imaging datasets present difficult challenges for feature extraction and data mining due to huge numbers of features that cannot be simultaneously examined. The sample numbers and variables of these methods
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fd61ee8aa985a5f6076c40d93227b70a
https://doi.org/10.1101/2020.09.03.269555
https://doi.org/10.1101/2020.09.03.269555
Autor:
Paul Timpson, Nelson Russia, Jennifer P. Morton, Val Gebski, John Kokkinos, Anthony J. Gill, Arafath Kaja Najumudeen, Jeff Holst, Koroush S. Haghighi, Minoti V. Apte, Joshua A. McCarroll, Chantal Kopecky, Anouschka Akerman, Angela Chou, Jessica L. Chitty, Janet Youkhana, David Goldstein, Stephanie Naim, Mert Erkan, Thomas P. Davis, Owen J. Sansom, Phoebe A. Phillips, Nigel Turner, Thomas R. Cox, Rosa Mistica C. Ignacio, George Sharbeen, Estrella Gonzales-Aloy, Julia Lee, Sigrid K. Fey, Amber L. Johns, Jie Liu, Cyrille Boyer, Brooke A. Pereira, Andrew D. Campbell
Cancer-Associated Fibroblasts (CAFs) are major contributors to pancreatic ductal adenocarcinoma (PDAC) progression, through pro-tumour cross-talk and the generation of fibrosis (physical barrier to drugs). CAF inhibition is thus an ideal component of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::311239113c6c59995bc8590e7a3a457d
https://doi.org/10.1101/2020.07.12.199638
https://doi.org/10.1101/2020.07.12.199638