Zobrazeno 1 - 10
of 23
pro vyhledávání: '"Arafath K, Najumudeen"'
Autor:
Johanna Lilja, Jasmin Kaivola, James R. W. Conway, Joni Vuorio, Hanna Parkkola, Pekka Roivas, Michal Dibus, Megan R. Chastney, Taru Varila, Guillaume Jacquemet, Emilia Peuhu, Emily Wang, Ulla Pentikäinen, Itziar Martinez D. Posada, Hellyeh Hamidi, Arafath K. Najumudeen, Owen J. Sansom, Igor L. Barsukov, Daniel Abankwa, Ilpo Vattulainen, Marko Salmi, Johanna Ivaska
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-20 (2024)
Abstract The KRAS oncogene drives many common and highly fatal malignancies. These include pancreatic, lung, and colorectal cancer, where various activating KRAS mutations have made the development of KRAS inhibitors difficult. Here we identify the s
Externí odkaz:
https://doaj.org/article/aab4a06c715b4e4481e20d3e6037ab7e
Autor:
Arafath K. Najumudeen, Sigrid K. Fey, Laura M. Millett, Catriona A. Ford, Kathryn Gilroy, Nuray Gunduz, Rachel A. Ridgway, Eve Anderson, Douglas Strathdee, William Clark, Colin Nixon, Jennifer P. Morton, Andrew D. Campbell, Owen J. Sansom
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-14 (2024)
Abstract Oncogenic KRAS mutations are well-described functionally and are known to drive tumorigenesis. Recent reports describe a significant prevalence of KRAS allelic imbalances or gene dosage changes in human cancers, including loss of the wild-ty
Externí odkaz:
https://doaj.org/article/cc435f850ded4ca6b07a54a34129b55d
Autor:
Amy K. Holt, Arafath K. Najumudeen, Tracey J. Collard, Hao Li, Laura M. Millett, Ashley J. Hoskin, Danny N. Legge, Eleanor M. H. Mortensson, Dustin J. Flanagan, Nicholas Jones, Madhu Kollareddy, Penny Timms, Matthew D. Hitchings, James Cronin, Owen J. Sansom, Ann C. Williams, Emma E. Vincent
Publikováno v:
Cancer & Metabolism, Vol 11, Iss 1, Pp 1-19 (2023)
Abstract Background To support proliferation and survival within a challenging microenvironment, cancer cells must reprogramme their metabolism. As such, targeting cancer cell metabolism is a promising therapeutic avenue. However, identifying tractab
Externí odkaz:
https://doaj.org/article/d2b8ee6de35a474887a1c18cb634d284
Autor:
Joshua D. G. Leach, Nikola Vlahov, Petros Tsantoulis, Rachel A. Ridgway, Dustin J. Flanagan, Kathryn Gilroy, Nathalie Sphyris, Ester G. Vázquez, David F. Vincent, William J. Faller, Michael C. Hodder, Alexander Raven, Sigrid Fey, Arafath K. Najumudeen, Douglas Strathdee, Colin Nixon, Mark Hughes, William Clark, Robin Shaw, S:CORT consortium, Sander R. van Hooff, David J. Huels, Jan Paul Medema, Simon T. Barry, Margaret C. Frame, Asier Unciti-Broceta, Simon J. Leedham, Gareth J. Inman, Rene Jackstadt, Barry J. Thompson, Andrew D. Campbell, Sabine Tejpar, Owen J. Sansom
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
Right-sided colorectal cancer (rCRC) has a different mutational spectrum to the left-sided counterpart. Here the authors develop a mouse model of rCRC that recapitulates human BRAF-mutant rCRC and show that loss of TGFβ-receptor signalling and infla
Externí odkaz:
https://doaj.org/article/e406c430dd004d04b04b4ed7f56f1c67
Autor:
Owen J. Sansom, Martin Bushell, Anne E. Willis, Joanne Edwards, John Le Quesne, William J. Faller, Heather J. McKinnon, Martin E. Swarbrick, Neil P. Jones, Christopher G. Proud, Nahum Sonenberg, Kevin M. Haigis, Nicola Valeri, Georgios Vlachogiannis, Andrew D. Campbell, Joseph A. Waldron, Rene Jackstadt, Joshua D. Leach, Emma Stanway, Kerri McArthur, Anne Cheasty, Craig MacKay, Laura McDonald, Rachael C.L. Smith, Dustin J. Flanagan, Rachel A. Ridgway, Kathryn Gilroy, Arafath K. Najumudeen, Ewan M. Smith, Sebastian May-Wilson, David M. Gay, Georgios Kanellos, Ana Teodosio, Leah Officer, Kathryn Pennel, Nikola Vlahov, George L. Skalka, Constantinos Alexandrou, John R.P. Knight
All supplemental figures and legends
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2cee3a26e547749f005f869f86f6004e
https://doi.org/10.1158/2159-8290.22540555
https://doi.org/10.1158/2159-8290.22540555
Autor:
Owen J. Sansom, Martin Bushell, Anne E. Willis, Joanne Edwards, John Le Quesne, William J. Faller, Heather J. McKinnon, Martin E. Swarbrick, Neil P. Jones, Christopher G. Proud, Nahum Sonenberg, Kevin M. Haigis, Nicola Valeri, Georgios Vlachogiannis, Andrew D. Campbell, Joseph A. Waldron, Rene Jackstadt, Joshua D. Leach, Emma Stanway, Kerri McArthur, Anne Cheasty, Craig MacKay, Laura McDonald, Rachael C.L. Smith, Dustin J. Flanagan, Rachel A. Ridgway, Kathryn Gilroy, Arafath K. Najumudeen, Ewan M. Smith, Sebastian May-Wilson, David M. Gay, Georgios Kanellos, Ana Teodosio, Leah Officer, Kathryn Pennel, Nikola Vlahov, George L. Skalka, Constantinos Alexandrou, John R.P. Knight
KRAS-mutant colorectal cancers are resistant to therapeutics, presenting a significant problem for ∼40% of cases. Rapalogs, which inhibit mTORC1 and thus protein synthesis, are significantly less potent in KRAS-mutant colorectal cancer. Using Kras-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4f56670615fce027f717d8d9f47081b8
https://doi.org/10.1158/2159-8290.c.6549409
https://doi.org/10.1158/2159-8290.c.6549409
Autor:
Phoebe A. Phillips, Yordanos F. Setargew, Benjamin J. McLean, Jorjina Kasparian, Koroush S. Haghighi, Jennifer P. Morton, Thomas P. Davis, Minoti V. Apte, Nigel Turner, Marina Pajic, Yi Fang Guan, Val Gebski, Estrella Gonzales-Aloy, Anthony J. Gill, Amber Johns, Angela Chou, Julia Lee, Nelson Russia, Jie Liu, Stephanie Naim, Rosa Mistica C. Ignacio, Owen J. Sansom, Andrew D. Campbell, Arafath K. Najumudeen, Sigrid K. Fey, Jessica L. Chitty, Brooke A. Pereira, Thomas R. Cox, Paul Timpson, David Goldstein, Mert Erkan, Cyrille Boyer, Jeff Holst, John Kokkinos, Janet Youkhana, Chantal Kopecky, Anouschka Akerman, Joshua A. McCarroll, George Sharbeen
Cancer-associated fibroblasts (CAF) are major contributors to pancreatic ductal adenocarcinoma (PDAC) progression through protumor signaling and the generation of fibrosis, the latter of which creates a physical barrier to drugs. CAF inhibition is th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::86d65521fa58365f055bbf9ff1e8f1ff
https://doi.org/10.1158/0008-5472.c.6512931.v1
https://doi.org/10.1158/0008-5472.c.6512931.v1
Autor:
Phoebe A. Phillips, Yordanos F. Setargew, Benjamin J. McLean, Jorjina Kasparian, Koroush S. Haghighi, Jennifer P. Morton, Thomas P. Davis, Minoti V. Apte, Nigel Turner, Marina Pajic, Yi Fang Guan, Val Gebski, Estrella Gonzales-Aloy, Anthony J. Gill, Amber Johns, Angela Chou, Julia Lee, Nelson Russia, Jie Liu, Stephanie Naim, Rosa Mistica C. Ignacio, Owen J. Sansom, Andrew D. Campbell, Arafath K. Najumudeen, Sigrid K. Fey, Jessica L. Chitty, Brooke A. Pereira, Thomas R. Cox, Paul Timpson, David Goldstein, Mert Erkan, Cyrille Boyer, Jeff Holst, John Kokkinos, Janet Youkhana, Chantal Kopecky, Anouschka Akerman, Joshua A. McCarroll, George Sharbeen
SLC7A11 knockdown in PDAC CAFs does not affect glutamate secretion and is maintained in the presence of oxidative stress.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6392a8bb5adc4a0965731494b29c63cd
https://doi.org/10.1158/0008-5472.22428168
https://doi.org/10.1158/0008-5472.22428168
Autor:
Phoebe A. Phillips, Yordanos F. Setargew, Benjamin J. McLean, Jorjina Kasparian, Koroush S. Haghighi, Jennifer P. Morton, Thomas P. Davis, Minoti V. Apte, Nigel Turner, Marina Pajic, Yi Fang Guan, Val Gebski, Estrella Gonzales-Aloy, Anthony J. Gill, Amber Johns, Angela Chou, Julia Lee, Nelson Russia, Jie Liu, Stephanie Naim, Rosa Mistica C. Ignacio, Owen J. Sansom, Andrew D. Campbell, Arafath K. Najumudeen, Sigrid K. Fey, Jessica L. Chitty, Brooke A. Pereira, Thomas R. Cox, Paul Timpson, David Goldstein, Mert Erkan, Cyrille Boyer, Jeff Holst, John Kokkinos, Janet Youkhana, Chantal Kopecky, Anouschka Akerman, Joshua A. McCarroll, George Sharbeen
Australian Pancreatic Cancer Genome Initiative International Cancer Genome Cohort patient cohort characteristics.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::07924398ea68cfd9441878bf940f9c25
https://doi.org/10.1158/0008-5472.22428159.v1
https://doi.org/10.1158/0008-5472.22428159.v1
Autor:
Phoebe A. Phillips, Yordanos F. Setargew, Benjamin J. McLean, Jorjina Kasparian, Koroush S. Haghighi, Jennifer P. Morton, Thomas P. Davis, Minoti V. Apte, Nigel Turner, Marina Pajic, Yi Fang Guan, Val Gebski, Estrella Gonzales-Aloy, Anthony J. Gill, Amber Johns, Angela Chou, Julia Lee, Nelson Russia, Jie Liu, Stephanie Naim, Rosa Mistica C. Ignacio, Owen J. Sansom, Andrew D. Campbell, Arafath K. Najumudeen, Sigrid K. Fey, Jessica L. Chitty, Brooke A. Pereira, Thomas R. Cox, Paul Timpson, David Goldstein, Mert Erkan, Cyrille Boyer, Jeff Holst, John Kokkinos, Janet Youkhana, Chantal Kopecky, Anouschka Akerman, Joshua A. McCarroll, George Sharbeen
SLC7A11 multivariate survival analysis parameters.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::904ffe21be5abe42d7185d5ba7397801
https://doi.org/10.1158/0008-5472.22428153
https://doi.org/10.1158/0008-5472.22428153