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pro vyhledávání: '"Arachidonyl trifluoromethyl ketone"'
Akademický článek
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Autor:
Hui Yang, Wei Sun, Jiqiao Yuan, Shuyi Li, Xuyu Li, Qi Hou, Fan Yannan, Mingbao Lin, Ziqian Zhang
Publikováno v:
Mediators of Inflammation
Mediators of Inflammation, Vol 2021 (2021)
Mediators of Inflammation, Vol 2021 (2021)
Perilla frutescens (L.) Britton is a classic herbal plant used widely against asthma in China. But its mechanism of beneficial effect remains undermined. In the study, the antiallergic asthma effects of Perilla leaf extract (PLE) were investigated, a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a29841066661dfcd9d0a0e69054bba82
https://doi.org/10.1155/2021/6611219
https://doi.org/10.1155/2021/6611219
Publikováno v:
Journal of Neurotrauma. 38:1327-1337
Surviving motoneurons undergo dendritic atrophy after spinal cord injury (SCI), suggesting an important therapeutic target for neuroprotective strategies to improve recovery of function after SCI. Our previous studies showed that phospholipase A2 (PL
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c6b8d685d6cd49a9250f058431c0c04f
https://doi.org/10.1089/neu.2014.3690
https://doi.org/10.1089/neu.2014.3690
Autor:
Axel Schambach, Adrian Schwarzer, Anna Lieske, Denise Klatt, Nicole Dörpmund, Olga S. Kustikova, Maike Stahlhut, Marc-Jens Kleppa, Dirk Hoffmann, Tobias Maetzig, Jacob Jalil Hassan
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 9411, p 9411 (2021)
International Journal of Molecular Sciences
Volume 22
Issue 17
International Journal of Molecular Sciences
Volume 22
Issue 17
HOXA9 and MEIS1 are frequently upregulated in acute myeloid leukemia (AML), including those with MLL-rearrangement. Because of their pivotal role in hemostasis, HOXA9 and MEIS1 appear non-druggable. We, thus, interrogated gene expression data of pre-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::78cab0238ea386bce838a0397176b23c
https://www.mdpi.com/1422-0067/22/17/9411
https://www.mdpi.com/1422-0067/22/17/9411
Publikováno v:
Journal of Cellular and Molecular Medicine
The only Na‐nutrient cotransporter described in mammalian small intestinal crypt cells is SN2/SNAT5, which facilitates glutamine uptake. In a rabbit model of chronic intestinal inflammation, SN2 stimulation is secondary to an increase in affinity o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4d3094ffb3273d2a6ff095ab1feaf6bf
https://doi.org/10.1111/jcmm.13257
https://doi.org/10.1111/jcmm.13257
Autor:
Wee Yong Ong, Yulin Lam, Mei-Lin Go, Yong Jun Chen, Francis Chee Kuan Tan, Chandra S. Verma, Chian-Ming Low, Srinivasaraghavan Kannan, Cheng Yang Ng
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-12 (2017)
Cytosolic phospholipase A2 (cPLA2) is an enzyme that releases arachidonic acid (AA) for the synthesis of eicosanoids and lysophospholipids which play critical roles in the initiation and modulation of oxidative stress and neuroinflammation. In the ce
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::01798ee664b60960be748a5d1326f3b2
http://link.springer.com/article/10.1038/s41598-017-13996-8
http://link.springer.com/article/10.1038/s41598-017-13996-8
Autor:
Stuart A. Nicklin, Ioana Alesutan, Dirk von Lewinski, Jean-Loup Bascands, Christian Delles, Beate Boehme, Guylène Feuillet, Trang T.D. Luong, Julie Klein, Nadeshda Schelski, Antonia Vlahou, Harald Mischak, William Mullen, Colette Denis, Burkert Pieske, Jakob Voelkl, Jean-Sébastien Saulnier-Blache, Agnieszka Latosinska, Florian Lang, Manousos Makridakis, Vasiliki Lygirou, Sophie Van Linthout, Joost P. Schanstra
Publikováno v:
JCI Insight
JCI Insight, 2019, 4 (10), pp.125638. ⟨10.1172/jci.insight.125638⟩
JCI Insight, American Society for Clinical Investigation, 2019, 4 (10), pp.125638. ⟨10.1172/jci.insight.125638⟩
JCI Insight, American Society for Clinical Investigation, 2019, 4 (10), pp.e125638. ⟨10.1172/jci.insight.125638⟩
JCI Insight, 2019, 4 (10), pp.125638. ⟨10.1172/jci.insight.125638⟩
JCI Insight, American Society for Clinical Investigation, 2019, 4 (10), pp.125638. ⟨10.1172/jci.insight.125638⟩
JCI Insight, American Society for Clinical Investigation, 2019, 4 (10), pp.e125638. ⟨10.1172/jci.insight.125638⟩
International audience; Although cardiovascular disease (CVD) is the leading cause of morbimortality worldwide, promising new drug candidates are lacking. We compared the arterial high-resolution proteome of patients with advanced versus early-stage
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::362498f808f165d0218c5a057d0801d4
https://www.hal.inserm.fr/inserm-02444365
https://www.hal.inserm.fr/inserm-02444365
Publikováno v:
Chidgey, J, Fraser, P A & Aaronson, P I 2016, ' Reactive oxygen species facilitate the EDH response in arterioles by potentiating intracellular endothelial Ca2+ release ', Free Radical Biology and Medicine . https://doi.org/10.1016/j.freeradbiomed.2016.06.010
Free Radical Biology & Medicine
Free Radical Biology & Medicine
There is abundant evidence that H2O2 can act as an endothelium-derived hyperpolarizing factor in the resistance vasculature. However, whilst scavenging H2O2 can abolish endothelial dependent hyperpolarization (EDH) and the associated vascular relaxat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::738f934f8eafceecdae9bc503def72eb
Autor:
Mikhail V. Dubinin, Igor A. Dyachenko, Konstantin N. Belosludtsev, Maxim E. Astashev, Nikita V. Penkov, Victor N. Samartsev, Sergey V. Gudkov
Publikováno v:
The Journal of Membrane Biology. 249:339-347
The work examines the effect of inhibitors of cytosolic Ca(2+)-dependent and Ca(2+)-independent phospholipases A2 on bilayer lipid membranes. It was established that trifluoroperazine (TFP) and, to a lesser extent, arachidonyl trifluoromethyl ketone
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d7255d2047a5759cabc2b9d31ceef307
https://doi.org/10.1007/s00232-016-9872-7
https://doi.org/10.1007/s00232-016-9872-7
Autor:
Xiumei Wang, Minghua Sui, Xuan Zhao, Weiwei Zhang, Liangming Zhang, Dengjun Sun, Jing Jiang, Chunxia Xin, Yanchun Wang, Ping Sui, Dongmei Geng
Publikováno v:
DNA and cell biology.
Phospholipase A2-IVA (PLA2G4A) is the most abundant subtype of cytoplasmic phospholipase A2 (cPLA2) and is an important enzyme in tumor development. Our study aimed to explore the role of PLA2G4A in the regulation of lung cancer. The contents of cell
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a572209044a3e202c509c5f95bdec27b
https://pubmed.ncbi.nlm.nih.gov/30328712
https://pubmed.ncbi.nlm.nih.gov/30328712