Zobrazeno 1 - 10
of 33
pro vyhledávání: '"Ara M Abramyan"'
Autor:
J Robert Lane, Ara M Abramyan, Pramisha Adhikari, Alastair C Keen, Kuo-Hao Lee, Julie Sanchez, Ravi Kumar Verma, Herman D Lim, Hideaki Yano, Jonathan A Javitch, Lei Shi
Publikováno v:
eLife, Vol 9 (2020)
By analyzing and simulating inactive conformations of the highly homologous dopamine D2 and D3 receptors (D2R and D3R), we find that eticlopride binds D2R in a pose very similar to that in the D3R/eticlopride structure but incompatible with the D2R/r
Externí odkaz:
https://doaj.org/article/22ae5702392642ec91760a357236acbd
Autor:
Ravi Kumar Verma, Ara M Abramyan, Mayako Michino, R Benjamin Free, David R Sibley, Jonathan A Javitch, J Robert Lane, Lei Shi
Publikováno v:
PLoS Computational Biology, Vol 14, Iss 1, p e1005948 (2018)
The dopamine D2 and D3 receptors (D2R and D3R) are important targets for antipsychotics and for the treatment of drug abuse. SB269652, a bitopic ligand that simultaneously binds both the orthosteric binding site (OBS) and a secondary binding pocket (
Externí odkaz:
https://doaj.org/article/c32595f0cebf4f86b145258df520dd63
Publikováno v:
ACS Central Science, Vol 10, Iss 5, Pp 1044-1053 (2024)
Externí odkaz:
https://doaj.org/article/dc2e4eb49e3a478e8d308603d8956dad
Publikováno v:
Computational and Structural Biotechnology Journal, Vol 18, Iss , Pp 199-206 (2020)
The sigma 1 receptor (σ1R) is a unique endoplasmic reticulum membrane protein. Its ligands have been shown to possess therapeutic potential for neurological and substance use disorders among others. The E102Q mutation of σ1R has been found to elici
Externí odkaz:
https://doaj.org/article/7f534a138e184cc19cf26b34582a5e2f
Autor:
Zoe L. Watson, Isaac Knudson, Fred R. Ward, Scott J. Miller, Jamie H. D. Cate, Alanna Schepartz, Ara M. Abramyan
As genetic code expansion advances beyond L-α-amino acids to backbone modifications and new polymerization chemistries, the field faces an increasingly broad challenge to discover what the ribosome can accommodate. Although the E. coli ribosome tole
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cf3a15e66d52e2a3452ba1937f3d98c3
https://doi.org/10.1101/2022.08.13.503842
https://doi.org/10.1101/2022.08.13.503842
Autor:
Disha M. Gandhi, Ara M. Abramyan, Xin Hu, Jeffrey Aubé, Kevin J. Frankowski, David R. Sibley, Emmanuel Akano, Lei Shi, Joseph P. Steiner, Thomas M. Keck, Marc Ferrer, Amy E. Moritz, R. Benjamin Free, Warren S. Weiner, Noel Southall
Publikováno v:
J Med Chem
To identify novel D3 dopamine receptor (D3R) agonists, we conducted a high-throughput screen using a β-arrestin recruitment assay. Counterscreening of the hit compounds provided an assessment of their selectivity, efficacy, and potency. The most pro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::71df63d947d47819d658d465cac70a62
https://doi.org/10.1021/acs.jmedchem.0c00424
https://doi.org/10.1021/acs.jmedchem.0c00424
Autor:
Ara M. Abramyan, Lei Shi, Claus J. Loland, Ulrik Gether, Arne Mørk, Benny Bang-Andersen, Per Plenge, Gunnar Sørensen, Pia Weikop
Publikováno v:
Nature Communications
Nature Communications, Vol 11, Iss 1, Pp 1-12 (2020)
Plenge, P, Abramyan, A M, Sørensen, G, Mork, A, Weikop, P, Gether, U, Bang-Andersen, B, Shi, L & Loland, C J 2020, ' The mechanism of a high-affinity allosteric inhibitor of the serotonin transporter ', Nature Communications, vol. 11, no. 1, 1491 . https://doi.org/10.1038/s41467-020-15292-y
Nature Communications, Vol 11, Iss 1, Pp 1-12 (2020)
Plenge, P, Abramyan, A M, Sørensen, G, Mork, A, Weikop, P, Gether, U, Bang-Andersen, B, Shi, L & Loland, C J 2020, ' The mechanism of a high-affinity allosteric inhibitor of the serotonin transporter ', Nature Communications, vol. 11, no. 1, 1491 . https://doi.org/10.1038/s41467-020-15292-y
The serotonin transporter (SERT) terminates serotonin signaling by rapid presynaptic reuptake. SERT activity is modulated by antidepressants, e.g., S-citalopram and imipramine, to alleviate symptoms of depression and anxiety. SERT crystal structures
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::51135ede0d0432322ed2914a8c5cf861
http://europepmc.org/articles/PMC7083837
http://europepmc.org/articles/PMC7083837
Autor:
Julie Sanchez, Herman D. Lim, Ravi Kumar Verma, Ara M. Abramyan, Kuo-Hao Lee, Hideaki Yano, Lei Shi, Pramisha Adhikari, Jonathan A. Javitch, J. Robert Lane, Alastair C. Keen
Publikováno v:
eLife, Vol 9 (2020)
eLife
eLife
By analyzing and simulating inactive conformations of the highly homologous dopamine D2 and D3 receptors (D2R and D3R), we find that eticlopride binds D2R in a pose very similar to that in the D3R/eticlopride structure but incompatible with the D2R/r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cad8b8e322c324ef2f01ce0eac02ab9a
https://nottingham-repository.worktribe.com/file/4046260/1/elife-52189-v1
https://nottingham-repository.worktribe.com/file/4046260/1/elife-52189-v1
Autor:
Lei Shi, Julie Sanchez, Hideaki Yano, Ara M. Abramyan, Herman D. Lim, Kuo-Hao Lee, Alastair C. Keen, Pramisha Adhikari, Ravi Kumar Verma, J. Robert Lane, Jonathan A. Javitch
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3ad6e09cbdc594b3e2f570a7ed730a74
https://doi.org/10.7554/elife.52189.sa2
https://doi.org/10.7554/elife.52189.sa2
Autor:
Mayako Michino, J. Robert Lane, Carmen Klein Herenbrink, Arthur Christopoulos, Jonathan A. Javitch, Ravi Kumar Verma, Jeremy Shonberg, Ara M. Abramyan, Peter J. Scammells, David M. Thal, Anitha Kopinathan, Christopher J Draper-Joyce, Ben Capuano, Lei Shi
Publikováno v:
Scientific Reports, Vol 8, Iss 1, Pp 1-12 (2018)
Sodium ions (Na+) allosterically modulate the binding of orthosteric agonists and antagonists to many class A G protein-coupled receptors, including the dopamine D2 receptor (D2R). Experimental and computational evidences have revealed that this effe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b3f896e416e29ab56b9a0f7bd6151f01
http://link.springer.com/article/10.1038/s41598-018-19642-1
http://link.springer.com/article/10.1038/s41598-018-19642-1