Zobrazeno 1 - 10
of 253
pro vyhledávání: '"Ara, M. P."'
Publikováno v:
ACS Central Science, Vol 10, Iss 5, Pp 1044-1053 (2024)
Externí odkaz:
https://doaj.org/article/dc2e4eb49e3a478e8d308603d8956dad
Akademický článek
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Publikováno v:
ACS Central Science; 5/22/2024, Vol. 10 Issue 5, p1044-1053, 10p
Akademický článek
Tento výsledek nelze pro nepřihlášené uživatele zobrazit.
K zobrazení výsledku je třeba se přihlásit.
K zobrazení výsledku je třeba se přihlásit.
Autor:
Per Plenge, Ara M. Abramyan, Gunnar Sørensen, Arne Mørk, Pia Weikop, Ulrik Gether, Benny Bang-Andersen, Lei Shi, Claus J. Loland
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-12 (2020)
The serotonin transporter (SERT) terminates serotonin signaling and its activity is modulated by antidepressants. Here authors reveal the mechanistic details underlying the coupling between the two binding sites in SERT and a high-affinity ligand for
Externí odkaz:
https://doaj.org/article/4706c23f56b542ffad3d502b3f12fe7e
Publikováno v:
Computational and Structural Biotechnology Journal, Vol 18, Iss , Pp 199-206 (2020)
The sigma 1 receptor (σ1R) is a unique endoplasmic reticulum membrane protein. Its ligands have been shown to possess therapeutic potential for neurological and substance use disorders among others. The E102Q mutation of σ1R has been found to elici
Externí odkaz:
https://doaj.org/article/7f534a138e184cc19cf26b34582a5e2f
Publikováno v:
ACS Central Science; May 2024, Vol. 10 Issue: 5 p1044-1053, 10p
Autor:
Jordi Bonaventura, Mark A. G. Eldridge, Feng Hu, Juan L. Gomez, Marta Sanchez-Soto, Ara M. Abramyan, Sherry Lam, Matthew A. Boehm, Christina Ruiz, Mitchell R. Farrell, Andrea Moreno, Islam Mustafa Galal Faress, Niels Andersen, John Y. Lin, Ruin Moaddel, Patrick J. Morris, Lei Shi, David R. Sibley, Stephen V. Mahler, Sadegh Nabavi, Martin G. Pomper, Antonello Bonci, Andrew G. Horti, Barry J. Richmond, Michael Michaelides
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-12 (2019)
Designer Receptors Exclusively Activated by Designer Drugs (DREADDs) are a powerful tool for neuroscience, but the standard DREADD ligand, CNO, has significant drawbacks. Here the authors report two novel high-potency DREADD ligands and a novel DREAD
Externí odkaz:
https://doaj.org/article/61041765c18b4742add3c9f64f5d7580
Autor:
Gili, Margalida, Castro, Adoración, García-Palacios, Azucena, Garcia-Campayo, Javier, Mayoral-Cleries, Fermin, Botella, Cristina, Roca, Miquel, Barceló-Soler, Alberto, Hurtado, María M, Navarro, MªTeresa, Villena, Amelia, Pérez-Ara, M Ángeles, Riera-Serra, Pau, Baños, Rosa Mª
Publikováno v:
Journal of Medical Internet Research, Vol 22, Iss 6, p e15845 (2020)
BackgroundPrimary care is a major access point for the initial treatment of depression, but the management of these patients is far from optimal. The lack of time in primary care is one of the major difficulties for the delivery of evidence-based psy
Externí odkaz:
https://doaj.org/article/2217bd6eff3e4c3f94b9b1ba4d620579
Autor:
J Robert Lane, Ara M Abramyan, Pramisha Adhikari, Alastair C Keen, Kuo-Hao Lee, Julie Sanchez, Ravi Kumar Verma, Herman D Lim, Hideaki Yano, Jonathan A Javitch, Lei Shi
Publikováno v:
eLife, Vol 9 (2020)
By analyzing and simulating inactive conformations of the highly homologous dopamine D2 and D3 receptors (D2R and D3R), we find that eticlopride binds D2R in a pose very similar to that in the D3R/eticlopride structure but incompatible with the D2R/r
Externí odkaz:
https://doaj.org/article/22ae5702392642ec91760a357236acbd