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EGF activates an inducible survival response via the RAS-> Erk-1/2 pathway to counteract interferon-α-mediated apoptosis in epidermoid cancer cells

Autor: Alberto Abbruzzese, Giovanni Vitale, M. Marra, S. Improta, E. Di Gennaro, G. Giuberti, Salvatore Venuta, Michele Caraglia, Stefano Pepe, Pierfrancesco Tassone, Pierosandro Tagliaferri, Alfredo Budillon, Ar Bianco

Publikováno v: Cell Death & Differentiation. 10:218-229

The mechanisms of tumor cell resistance to interferon-alpha (IFNalpha) are at present mostly unsolved. We have previously demonstrated that IFNalpha induces apoptosis on epidermoid cancer cells and EGF antagonizes this effect. We have also found that

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::67c4d25d2d4fada03b8901ade5447480
https://doi.org/10.1038/sj.cdd.4401131

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Gemcitabine combined with continuous infusion 5-fluorouracil in advanced and symptomatic pancreatic cancer: a clinical benefit-oriented phase II study

Autor: Pierosandro Tagliaferri, Vincenzo Damiano, A.M. Libroia, Ar Bianco, Antonietta Fabbrocini, S. De Lorenzo, Elide Matano

Publikováno v: British Journal of Cancer

Gemcitabine and 5-fluorouracil are the only two compounds with reproducible activity against advanced pancreatic cancer (APC). We have evaluated a novel combination of gemcitabine and 5-fluorouracil on the clinical benefit response (CBR) end point. E

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eadb9bf01b023103d78ceca7d2574948
https://doi.org/10.1054/bjoc.1999.1139

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'Modulation of 5-fluorouracil as adjuvant systemic chemotherapy in colorectal cancer:the IGCS-COL multicentre, randomised, phase III study'

Autor: SDE PLACIDO, GPAOLETTI, SPALAZZO, LMANZIONE, CIANNACE, GP IANNIELLO, FDE VITA, CFICORELLA, AFARRIS, GPISTILLUCCI, MGEMINI, E. CORTESI, CGALLO, FPERRONE, GPERSICO, AR BIANCO, LOPEZ, Manuela, GEBBIA, Nicolo', PALMERI, Sergio

The aims of this multicentre, randomised phase III trial were to evaluate: (1) the role of levamisol (LEV); and (2) the role of folinic acid (FA), added to 5-fluorouracil (5FU) in the adjuvant treatment of colorectal cancer. Patients with histologica

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od______3658::9f457648e2614ab66ffe49055d5ec03a
http://hdl.handle.net/10447/2216

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Desferioxamine increases iron depletion and apoptosis induced by ara-C of human myeloid leukaemic cells

Autor: M. Musico, S. De Lorenzo, Alberto Abbruzzese, Michele Caraglia, Stefano Pepe, Antonietta Fabbrocini, Carmine Selleri, Pierosandro Tagliaferri, Claudia Pizzi, A Leardi, Ar Bianco, Rosario Notaro

Publikováno v: British Journal of Haematology. 102:746-752

We investigated whether changes in iron metabolism and the transferrin receptor (TRF-R) expression were involved in the antileukaemic effects of arabinoside cytosine (ara-C). Treatment with 100 n M ara-C for 48 h reduced thymidine uptake and increase

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::4e7fd1f98429a818c60c792e8a6606f1
https://doi.org/10.1046/j.1365-2141.1998.00834.x

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Vinorelbine is well tolerated and active in the treatment of elderly patients with advanced non-small cell lung cancer. A two-stage phase II study

Autor: Alessandra Rossi, C. Gridelli, M. D'Aprile, R. Migliorino, S. Cigolari, Ciro Gallo, S. Cariello, Ar Bianco, F. De Marinis, F. Di Costanzo, R. Bartolucci, Silvio Monfardini, M. Pergola, F. Perrone, G P Ianniello

Publikováno v: European Journal of Cancer. 33:392-397

More than 30% of lung cancers arise in patients aged 70 years or more; however, because elderly patients are not considered to tolerate chemotherapy, they are generally excluded from clinical trials and are not considered eligible for aggressive cisp

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8c28299ff132acfc3f0e0ee665d760e1
https://doi.org/10.1016/s0959-8049(97)89011-9

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First-line systemic therapy for metastatic breast cancer and management of pleural effusion

Autor: Chiara Carlomagno, Rossella Lauria, S. De Placido, Alessandro Morabito, Ar Bianco, F. Perrone

Publikováno v: Scopus-Elsevier

S.A. was a 35-year-old woman when, in October 1988, she discovered a nodule in her right breast and was referred to a surgeon. She had a family history of breast cancer and was nulliparous. Physical examination revealed a stony hard nodule of 2.5 cm

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5cab930ef8cbe24d92c1e958becc5c07
https://doi.org/10.1093/oxfordjournals.annonc.a059068

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90k is a serum marker of poor-prognosis in non-hodgkins-lymphoma patients

Autor: Pierosandro Tagliaferri, Stefano Iacobelli, Giovannella Palmieri, Clara Natoli, Nicola Tinari, Ar Bianco, Antonino Grassadonia, A Rea, Alessandro Morabito

Publikováno v: Oncology reports. 1(4)

Monoclonal antibody SP-2, which binds to a 90,000 daltons tumor-associated antigen termed 90K, was generated by mouse immunization with proteins released by human breast cancer cells into the culture medium (Iacobelli et al: Cancer Res 46: 3005-3010,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::db8353ff762cf23e529fd9295d6e8dd2
https://pubmed.ncbi.nlm.nih.gov/21607429

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