Identification of a critical binding site for local anaesthetics in the side pockets of K v 1 channels.

Autor: Kiper AK; Institute for Physiology and Pathophysiology, Philipps-University Marburg, Marburg, Germany., Bedoya M; Centro de Bioinformática y Simulación Molecular, Universidad de Talca, Talca, Chile.; Millennium Nucleus of Ion Channels-Associated Diseases (MiNICAD), Universidad de Talca, Talca, Chile., Stalke S; Institute for Physiology and Pathophysiology, Philipps-University Marburg, Marburg, Germany., Marzian S; Institute for Physiology and Pathophysiology, Philipps-University Marburg, Marburg, Germany., Ramírez D; Instituto de Ciencias Biomédicas, Universidad Autónoma de Chile, Santiago, Chile., de la Cruz A; Instituto de Investigaciones Biomédicas Alberto Sols, Consejo Superior de Investigaciones Científicas (CSIC) and Universidad Autónoma de Madrid (UAM), Madrid, Spain.; Spanish Network for Biomedical Research in Cardiovascular Research (CIBERCV), Instituto de Salud Carlos III, Madrid, Spain., Peraza DA; Instituto de Investigaciones Biomédicas Alberto Sols, Consejo Superior de Investigaciones Científicas (CSIC) and Universidad Autónoma de Madrid (UAM), Madrid, Spain.; Spanish Network for Biomedical Research in Cardiovascular Research (CIBERCV), Instituto de Salud Carlos III, Madrid, Spain., Vera-Zambrano A; Instituto de Investigaciones Biomédicas Alberto Sols, Consejo Superior de Investigaciones Científicas (CSIC) and Universidad Autónoma de Madrid (UAM), Madrid, Spain.; Spanish Network for Biomedical Research in Cardiovascular Research (CIBERCV), Instituto de Salud Carlos III, Madrid, Spain.; Biochemistry Department, School of Medicine, Universidad Autónoma de Madrid, Madrid, Spain., Márquez Montesinos JCE; Centro de Bioinformática y Simulación Molecular, Universidad de Talca, Talca, Chile., Arévalo Ramos BA; Centro de Bioinformática y Simulación Molecular, Universidad de Talca, Talca, Chile., Rinné S; Institute for Physiology and Pathophysiology, Philipps-University Marburg, Marburg, Germany., Gonzalez T; Instituto de Investigaciones Biomédicas Alberto Sols, Consejo Superior de Investigaciones Científicas (CSIC) and Universidad Autónoma de Madrid (UAM), Madrid, Spain.; Spanish Network for Biomedical Research in Cardiovascular Research (CIBERCV), Instituto de Salud Carlos III, Madrid, Spain.; Biochemistry Department, School of Medicine, Universidad Autónoma de Madrid, Madrid, Spain., Valenzuela C; Instituto de Investigaciones Biomédicas Alberto Sols, Consejo Superior de Investigaciones Científicas (CSIC) and Universidad Autónoma de Madrid (UAM), Madrid, Spain.; Spanish Network for Biomedical Research in Cardiovascular Research (CIBERCV), Instituto de Salud Carlos III, Madrid, Spain., Gonzalez W; Centro de Bioinformática y Simulación Molecular, Universidad de Talca, Talca, Chile.; Millennium Nucleus of Ion Channels-Associated Diseases (MiNICAD), Universidad de Talca, Talca, Chile., Decher N; Institute for Physiology and Pathophysiology, Philipps-University Marburg, Marburg, Germany.

Publikováno v: British journal of pharmacology [Br J Pharmacol] 2021 Aug; Vol. 178 (15), pp. 3034-3048. Date of Electronic Publication: 2021 May 14.