p38γ and p38δ regulate postnatal cardiac metabolism through glycogen synthase 1.

Autor: Ayelén M Santamans, Valle Montalvo-Romeral, Alfonso Mora, Juan Antonio Lopez, Francisco González-Romero, Daniel Jimenez-Blasco, Elena Rodríguez, Aránzazu Pintor-Chocano, Cristina Casanueva-Benítez, Rebeca Acín-Pérez, Luis Leiva-Vega, Jordi Duran, Joan J Guinovart, Jesús Jiménez-Borreguero, José Antonio Enríquez, María Villlalba-Orero, Juan P Bolaños, Patricia Aspichueta, Jesús Vázquez, Bárbara González-Terán, Guadalupe Sabio

Publikováno v: PLoS Biology, Vol 19, Iss 11, p e3001447 (2021)

During the first weeks of postnatal heart development, cardiomyocytes undergo a major adaptive metabolic shift from glycolytic energy production to fatty acid oxidation. This metabolic change is contemporaneous to the up-regulation and activation of

Externí odkaz: https://doaj.org/article/c36e9e81543246be91c8817f25d367e5

Neutrophil infiltration regulates clock-gene expression to organize daily hepatic metabolism

Autor: María Crespo, Barbara Gonzalez-Teran, Ivana Nikolic, Alfonso Mora, Cintia Folgueira, Elena Rodríguez, Luis Leiva-Vega, Aránzazu Pintor-Chocano, Macarena Fernández-Chacón, Irene Ruiz-Garrido, Beatriz Cicuéndez, Antonia Tomás-Loba, Noelia A-Gonzalez, Ainoa Caballero-Molano, Daniel Beiroa, Lourdes Hernández-Cosido, Jorge L Torres, Norman J Kennedy, Roger J Davis, Rui Benedito, Miguel Marcos, Ruben Nogueiras, Andrés Hidalgo, Nuria Matesanz, Magdalena Leiva, Guadalupe Sabio

Publikováno v: eLife, Vol 9 (2020)

Liver metabolism follows diurnal fluctuations through the modulation of molecular clock genes. Disruption of this molecular clock can result in metabolic disease but its potential regulation by immune cells remains unexplored. Here, we demonstrated t

Externí odkaz: https://doaj.org/article/68531b33dacf4efb84a24e972b0693bf

Neutrophil infiltration regulates clock-gene expression to organize daily hepatic metabolism

Autor: Norman J. Kennedy, Cintia Folgueira, Magdalena Leiva, Jorge L Torres, Lourdes Hernández-Cosido, Bárbara González-Terán, Luis Leiva-Vega, Ivana Nikolic, Miguel Marcos, Noelia A-Gonzalez, Andrés Hidalgo, Rui Benedito, Alfonso Mora, Irene Ruiz-Garrido, Aránzazu Pintor-Chocano, Ainoa Caballero-Molano, Nuria Matesanz, Elena Rodríguez, Roger J. Davis, Daniel Beiroa, Beatriz Cicuéndez, Macarena Fernández-Chacón, María Crespo, Guadalupe Sabio, Rubén Nogueiras, Antonia Tomás-Loba

Publikováno v: Repisalud
Instituto de Salud Carlos III (ISCIII)
eLife
eLife, Vol 9 (2020)

Liver metabolism follows diurnal fluctuations through the modulation of molecular clock genes. Disruption of this molecular clock can result in metabolic disease but its potential regulation by immune cells remains unexplored. Here, we demonstrated t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c5e2ad9f31b1bef9e1d18ed31f39f975
http://hdl.handle.net/20.500.12105/13249

p38γ is essential for cell cycle progression and liver tumorigenesis

Autor: Jesús Ruiz-Cabello, Aránzazu Pintor-Chocano, Bárbara González-Terán, Guadalupe Sabio, Luis Leiva-Vega, Marcos Malumbres, Jerónimo Bravo, Juan A. Bernal, Marta Roche-Molina, Yulia A. Nevzorova, Nuria Matesanz, Hannah E. Mischo, Jesús Vázquez, Antonia Tomás-Loba, Ainoa Caballero, Valle Montalvo-Romeral, Miguel Marcos, Elisa Manieri, Beatriz Caballero, Ferran Feixas, Lourdes Hernández-Cosido, Marianna Trakala, Marta León, Rafael Romero-Becerra, Francisco Javier Cubero, Elena Rodríguez, Alfonso Mora, Oscar Blanco, Jorge L Torres, Juan Antonio López, Sílvia Osuna, Ayelén M Santamans, Diego Miranda-Saavedra

Publikováno v: Repisalud
Instituto de Salud Carlos III (ISCIII)
Digital.CSIC. Repositorio Institucional del CSIC
instname
Tomás-loba, A, Manieri, E, González-terán, B, Mora, A, Leiva-vega, L, Santamans, A M, Romero-becerra, R, Rodríguez, E, Pintor-chocano, A, Feixas, F, López, J A, Caballero, B, Trakala, M, Blanco, Ó, Torres, J L, Hernández-cosido, L, Montalvo-romeral, V, Matesanz, N, Roche-molina, M, Bernal, J A, Mischo, H, León, M, Caballero, A, Miranda-saavedra, D, Ruiz-cabello, J, Nevzorova, Y A, Cubero, F J, Bravo, J, Vázquez, J, Malumbres, M, Marcos, M, Osuna, S & Sabio, G 2019, ' p38γ is essential for cell cycle progression and liver tumorigenesis ', Nature, vol. 568, no. 7753, pp. 557-560 . https://doi.org/10.1038/s41586-019-1112-8

27 páginas, 4 figuras. Contiene material suplementario, método, 6 figuras en: https://doi.org/10.1038/s41586-019-1112-8
The cell cycle is a tightly regulated process that is controlled by the conserved cyclin-dependent kinase (CDK)-cyclin prot

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::469c33c1353c050aa904bf7d041c9c7a
https://pubmed.ncbi.nlm.nih.gov/30971822