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263 INFORMING INTERVENTION DESIGN IN COGNITIVELY IMPAIRED POPULATIONS: LESSONS LEARNED FROM THE OPTIMIZE DEPRESCRIBING INTERVENTION

Autor: OC Sheehan, EA Bayliss, AR Green, ML Drace, J Norton, E Reeve, SS Shetterly, S Gleason Kathy, LA Weffald, ML Maciejewski, C Kraus, M Maiyani, J Wolff, CM Boyd

Publikováno v: Age and Ageing. 51

Background Polypharmacy is common in older adults with cognitive impairment and multiple chronic conditions increasing their risks of adverse drug events, hospitalization, further cognitive decline and death and leading to higher health care costs. D

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::93e429b2cb0b7a3f678deef67aee0021
https://doi.org/10.1093/ageing/afac218.231

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Interstitial deletion constitutes the major mechanism for loss of heterozygosity on chromosome 20q in polycythemia vera

Autor: Fa, Asimakopoulos, James Gilbert, Ma, Aldred, Tc, Pearson, Ar, Green

Publikováno v: Europe PubMed Central

An acquired deletion of the long arm of chromosome 20 is a recurrent abnormality in myeloproliferative disorders, particularly polycythemia vera and myelodysplastic syndromes. The association of 20q deletions with myeloid "stem cell" disorders sugges

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::5e1bbc98a41c704215706aa01b404574
https://pubmed.ncbi.nlm.nih.gov/8839864

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Lineage-restricted regulation of the murine SCL/TAL-1 promoter

Autor: Ernesto Bockamp, McLaughlin F, Am, Murrell, Göttgens B, Robb L, Cg, Begley, Ar, Green

Publikováno v: Europe PubMed Central

The SCL/TAL-1 gene encodes a basic helix-loop-helix transcription factor that is expressed in multipotent hematopoietic progenitors before lineage commitment. Its expression is maintained during differentiation along erythroid, mast, and megakaryocyt

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::e2d5ac2d45f8b686df2f0bb14a2b6824
https://pubmed.ncbi.nlm.nih.gov/7632958

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Molecular analysis of chromosome 20q deletions associated with myeloproliferative disorders and myelodysplastic syndromes

Autor: FA Asimakopoulos, NJ White, E Nacheva, AR Green

Publikováno v: Blood. 84(9)

Acquired deletions of the long arm of chromosome 20 are found in several hematologic conditions and particularly in the myeloproliferative disorders and myelodysplastic syndromes. The spectrum of diseases associated with 20q deletions suggests that s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7611cbfb252a6330ad20a4b31af1c7bb
https://pubmed.ncbi.nlm.nih.gov/7949181

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Tumour cell membrane laminin expression is associated with basal-like phenotype and poor survival in Nigerian breast cancer

Autor: Ayodeji Agboola, Ho, Ebili, Vo, Iyawe, Aa, Banjo, Bs, Salami, Ea, Rakha, Nolan C, Io, Ellis, Ar, Green

Publikováno v: Europe PubMed Central

Laminin is a glycoprotein with diverse functions in carcinogenesis including cell proliferation, invasion, metastases and epithelial-mesenchymal transition (EMT). In breast cancer (BC) laminin expression is speculated to be associated with unfavourab

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::bf16246109e5b799e732c825e285a001
http://europepmc.org/abstract/med/27568664

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Cytokine-induced megakaryocytic differentiation is regulated by genome-wide loss of a uSTAT transcriptional program

Autor: Hj, Park, Li J, Hannah R, Simon Biddie, Ai, Leal-Cervantes, Kirschner K, Flores Santa Cruz D, Sexl V, Göttgens B, Ar, Green

Publikováno v: Europe PubMed Central

Metazoan development is regulated by transcriptional networks, which must respond to extracellular cues including cytokines. The JAK/STAT pathway is a highly conserved regulatory module, activated by many cytokines, in which tyrosine-phosphorylated S

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::2361217f709bad32713606004c2857b6
http://europepmc.org/abstract/med/26702099

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