Design and Synthesis of Acyclic Boronic Acid Arginase Inhibitors.

Autor: Shields JD; Early Oncology R&D, AstraZeneca, 35 Gatehouse Drive, Waltham, Massachusetts 02451, United States., Aquila BM; Early Oncology R&D, AstraZeneca, 35 Gatehouse Drive, Waltham, Massachusetts 02451, United States., Emmons D; Early Oncology R&D, AstraZeneca, 35 Gatehouse Drive, Waltham, Massachusetts 02451, United States., Finlay MRV; Early Oncology R&D, AstraZeneca, 1 Francis Crick Avenue, Cambridge CB2 0AA, U.K., Gangl ET; Early Oncology R&D, AstraZeneca, 35 Gatehouse Drive, Waltham, Massachusetts 02451, United States., Gu C; Early Oncology R&D, AstraZeneca, 35 Gatehouse Drive, Waltham, Massachusetts 02451, United States., Mlynarski SN; Early Oncology R&D, AstraZeneca, 35 Gatehouse Drive, Waltham, Massachusetts 02451, United States., Petersen J; Discovery Sciences, R&D, AstraZeneca, Pepparedsleden 1, SE-431 83 Mölndal, Sweden., Pop-Damkov P; Early Oncology R&D, AstraZeneca, 35 Gatehouse Drive, Waltham, Massachusetts 02451, United States., Sha L; Early Oncology R&D, AstraZeneca, 35 Gatehouse Drive, Waltham, Massachusetts 02451, United States., Simpson I; Early Oncology R&D, AstraZeneca, 1 Francis Crick Avenue, Cambridge CB2 0AA, U.K., Tavakoli S; Discovery Sciences, R&D, AstraZeneca, Pepparedsleden 1, SE-431 83 Mölndal, Sweden., Tentarelli S; Early Oncology R&D, AstraZeneca, 35 Gatehouse Drive, Waltham, Massachusetts 02451, United States., Wang H; Early Oncology R&D, AstraZeneca, 35 Gatehouse Drive, Waltham, Massachusetts 02451, United States., Ye Q; Early Oncology R&D, AstraZeneca, 35 Gatehouse Drive, Waltham, Massachusetts 02451, United States., Zheng X; Early Oncology R&D, AstraZeneca, 35 Gatehouse Drive, Waltham, Massachusetts 02451, United States.

Publikováno v: Journal of medicinal chemistry [J Med Chem] 2024 Nov 14. Date of Electronic Publication: 2024 Nov 14.

Positional Analogue Scanning: An Effective Strategy for Multiparameter Optimization in Drug Design.

Autor: Pennington LD, Aquila BM, Choi Y, Valiulin RA, Muegge I

Publikováno v: Journal of medicinal chemistry [J Med Chem] 2020 Sep 10; Vol. 63 (17), pp. 8956-8976. Date of Electronic Publication: 2020 Apr 24.

Discovery of Mcl-1-specific inhibitor AZD5991 and preclinical activity in multiple myeloma and acute myeloid leukemia.

Autor: Tron AE; Oncology, IMED Biotech Unit, AstraZeneca, Waltham, MA, 02451, USA., Belmonte MA; Oncology, IMED Biotech Unit, AstraZeneca, Waltham, MA, 02451, USA.; LifeMine Therapeutics, Cambridge, MA, USA., Adam A; Oncology, IMED Biotech Unit, AstraZeneca, Waltham, MA, 02451, USA.; Surface Oncology, Cambridge, MA, USA., Aquila BM; Oncology, IMED Biotech Unit, AstraZeneca, Waltham, MA, 02451, USA.; Alkermes, Inc., Waltham, MA, USA., Boise LH; Department of Hematology and Medical Oncology, Emory University School of Medicine, Atlanta, GA, 30322, USA.; Winship Cancer Institute of Emory University, Atlanta, GA, 30322, USA., Chiarparin E; Oncology, IMED Biotech Unit, AstraZeneca, Cambridge, CB4 0WG, UK., Cidado J; Oncology, IMED Biotech Unit, AstraZeneca, Waltham, MA, 02451, USA., Embrey KJ; Discovery Sciences, IMED Biotech Unit, AstraZeneca, Cambridge, CB4 0WG, UK., Gangl E; Oncology, IMED Biotech Unit, AstraZeneca, Waltham, MA, 02451, USA., Gibbons FD; Oncology, IMED Biotech Unit, AstraZeneca, Waltham, MA, 02451, USA., Gregory GP; School of Clinical Sciences at Monash Health, Monash University, Clayton, VIC, 3800, Australia.; Peter MacCallum Cancer Centre, Melbourne, VIC, 3000, Australia., Hargreaves D; Discovery Sciences, IMED Biotech Unit, AstraZeneca, Cambridge, CB4 0WG, UK., Hendricks JA; Discovery Sciences, IMED Biotech Unit, AstraZeneca, Waltham, MA, 02451, USA., Johannes JW; Oncology, IMED Biotech Unit, AstraZeneca, Waltham, MA, 02451, USA., Johnstone RW; Peter MacCallum Cancer Centre, Melbourne, VIC, 3000, Australia.; The Sir Peter MacCallum Center, Department of Oncology, University of Melbourne, Parkville, VIC, 3000, Australia., Kazmirski SL; Discovery Sciences, IMED Biotech Unit, AstraZeneca, Waltham, MA, 02451, USA.; Fulcrum Therapeutics, Cambridge, MA, USA., Kettle JG; Oncology, IMED Biotech Unit, AstraZeneca, Cambridge, CB4 0WG, UK., Lamb ML; Oncology, IMED Biotech Unit, AstraZeneca, Waltham, MA, 02451, USA., Matulis SM; Department of Hematology and Medical Oncology, Emory University School of Medicine, Atlanta, GA, 30322, USA.; Winship Cancer Institute of Emory University, Atlanta, GA, 30322, USA., Nooka AK; Department of Hematology and Medical Oncology, Emory University School of Medicine, Atlanta, GA, 30322, USA.; Winship Cancer Institute of Emory University, Atlanta, GA, 30322, USA., Packer MJ; Oncology, IMED Biotech Unit, AstraZeneca, Alderley Park, SK10 4TG, UK., Peng B; Oncology, IMED Biotech Unit, AstraZeneca, Waltham, MA, 02451, USA., Rawlins PB; Discovery Sciences, IMED Biotech Unit, AstraZeneca, Cambridge, CB4 0WG, UK., Robbins DW; Oncology, IMED Biotech Unit, AstraZeneca, Waltham, MA, 02451, USA.; Nurix, Inc., San Francisco, CA, USA., Schuller AG; Oncology, IMED Biotech Unit, AstraZeneca, Waltham, MA, 02451, USA., Su N; Discovery Sciences, IMED Biotech Unit, AstraZeneca, Waltham, MA, 02451, USA., Yang W; Pharmaceutical Sciences, IMED Biotech Unit, AstraZeneca, Waltham, MA, 02451, USA., Ye Q; Oncology, IMED Biotech Unit, AstraZeneca, Waltham, MA, 02451, USA., Zheng X; Oncology, IMED Biotech Unit, AstraZeneca, Waltham, MA, 02451, USA., Secrist JP; Oncology, IMED Biotech Unit, AstraZeneca, Waltham, MA, 02451, USA.; LifeMine Therapeutics, Cambridge, MA, USA., Clark EA; Oncology, IMED Biotech Unit, AstraZeneca, Waltham, MA, 02451, USA., Wilson DM; Oncology, IMED Biotech Unit, AstraZeneca, Cambridge, CB4 0WG, UK., Fawell SE; Oncology, IMED Biotech Unit, AstraZeneca, Waltham, MA, 02451, USA., Hird AW; Oncology, IMED Biotech Unit, AstraZeneca, Waltham, MA, 02451, USA. alexander.hird@astrazeneca.com.

Publikováno v: Nature communications [Nat Commun] 2018 Dec 17; Vol. 9 (1), pp. 5341. Date of Electronic Publication: 2018 Dec 17.

Exploring the combinatorial explosion of amine–acid reaction space via graph editing.

Autor: Zhang, Rui¹ (AUTHOR), Mahjour, Babak² (AUTHOR), Outlaw, Andrew² (AUTHOR), McGrath, Andrew² (AUTHOR), Hopper, Tim³ (AUTHOR), Kelley, Brian³ (AUTHOR), Walters, W. Patrick³ (AUTHOR), Cernak, Tim^1,2 (AUTHOR) tcernak@med.umich.edu

Publikováno v: Communications Chemistry. 2/3/2024, Vol. 7 Issue 1, p1-13. 13p.

Small molecule inhibitor of apoptosis proteins antagonists: a patent review.

Autor: Hird AW; AstraZeneca, Medicinal Chemistry, Oncology iMed , 35 Gatehouse Drive, Waltham, MA 02451 , USA +1 781 839 4145 ; alexander.hird@astrazeneca.com., Aquila BM, Hennessy EJ, Vasbinder MM, Yang B

Publikováno v: Expert opinion on therapeutic patents [Expert Opin Ther Pat] 2015 Jul; Vol. 25 (7), pp. 755-74. Date of Electronic Publication: 2015 May 18.