Childhood trauma and genetic variation in the DAT 40-bp VNTR contribute to HIV-associated neurocognitive disorders

Autor: Aqeedah Abbas Roomaney, Jacqueline Samantha Womersley, Patricia Cathryn Swart, Georgina Spies, Soraya Seedat, Sian Megan Joanna Hemmings

Publikováno v: IBRO Neuroscience Reports, Vol 12, Iss , Pp 45-54 (2022)

HIV/AIDS is a major public health burden in South Africa, currently affecting an estimated 13.5% of the population. Despite improved access to antiretroviral therapies, HIV-associated neurocognitive disorders (HAND), characterised by a spectrum of ne

Externí odkaz: https://doaj.org/article/8250275f0c074ae4863135ef7b2299b5

SARS-CoV-2 Viral Replication Persists in the Human Lung for Several Weeks after Symptom Onset.

Autor: Tomasicchio M; Centre for Lung Infection and Immunity, Division of Pulmonology, Department of Medicine, University of Cape Town and UCT Lung Institute, Cape Town, South Africa.; South African MRC Centre for the Study of Antimicrobial Resistance., Jaumdally S; Centre for Lung Infection and Immunity, Division of Pulmonology, Department of Medicine, University of Cape Town and UCT Lung Institute, Cape Town, South Africa.; South African MRC Centre for the Study of Antimicrobial Resistance., Wilson L; Centre for Lung Infection and Immunity, Division of Pulmonology, Department of Medicine, University of Cape Town and UCT Lung Institute, Cape Town, South Africa.; South African MRC Centre for the Study of Antimicrobial Resistance., Kotze A; Centre for Lung Infection and Immunity, Division of Pulmonology, Department of Medicine, University of Cape Town and UCT Lung Institute, Cape Town, South Africa.; South African MRC Centre for the Study of Antimicrobial Resistance., Semple L; Centre for Lung Infection and Immunity, Division of Pulmonology, Department of Medicine, University of Cape Town and UCT Lung Institute, Cape Town, South Africa.; South African MRC Centre for the Study of Antimicrobial Resistance., Meier S; Centre for Lung Infection and Immunity, Division of Pulmonology, Department of Medicine, University of Cape Town and UCT Lung Institute, Cape Town, South Africa.; South African MRC Centre for the Study of Antimicrobial Resistance., Pooran A; Centre for Lung Infection and Immunity, Division of Pulmonology, Department of Medicine, University of Cape Town and UCT Lung Institute, Cape Town, South Africa.; South African MRC Centre for the Study of Antimicrobial Resistance., Esmail A; Centre for Lung Infection and Immunity, Division of Pulmonology, Department of Medicine, University of Cape Town and UCT Lung Institute, Cape Town, South Africa.; South African MRC Centre for the Study of Antimicrobial Resistance., Pillay K; Division of Anatomical Pathology, Department of Pathology, and., Roberts R; Division of Anatomical Pathology, Department of Pathology, and., Kriel R; Division of Anatomical Pathology, Department of Pathology, and., Meldau R; Centre for Lung Infection and Immunity, Division of Pulmonology, Department of Medicine, University of Cape Town and UCT Lung Institute, Cape Town, South Africa.; South African MRC Centre for the Study of Antimicrobial Resistance., Oelofse S; Centre for Lung Infection and Immunity, Division of Pulmonology, Department of Medicine, University of Cape Town and UCT Lung Institute, Cape Town, South Africa.; South African MRC Centre for the Study of Antimicrobial Resistance., Mandviwala C; Centre for Lung Infection and Immunity, Division of Pulmonology, Department of Medicine, University of Cape Town and UCT Lung Institute, Cape Town, South Africa.; South African MRC Centre for the Study of Antimicrobial Resistance., Burns J; Centre for Lung Infection and Immunity, Division of Pulmonology, Department of Medicine, University of Cape Town and UCT Lung Institute, Cape Town, South Africa.; South African MRC Centre for the Study of Antimicrobial Resistance., Londt R; Centre for Lung Infection and Immunity, Division of Pulmonology, Department of Medicine, University of Cape Town and UCT Lung Institute, Cape Town, South Africa.; South African MRC Centre for the Study of Antimicrobial Resistance., Davids M; Centre for Lung Infection and Immunity, Division of Pulmonology, Department of Medicine, University of Cape Town and UCT Lung Institute, Cape Town, South Africa.; South African MRC Centre for the Study of Antimicrobial Resistance., van der Merwe C; Centre for Lung Infection and Immunity, Division of Pulmonology, Department of Medicine, University of Cape Town and UCT Lung Institute, Cape Town, South Africa.; South African MRC Centre for the Study of Antimicrobial Resistance., Roomaney A; Centre for Lung Infection and Immunity, Division of Pulmonology, Department of Medicine, University of Cape Town and UCT Lung Institute, Cape Town, South Africa.; South African MRC Centre for the Study of Antimicrobial Resistance., Kühn L; Centre for Lung Infection and Immunity, Division of Pulmonology, Department of Medicine, University of Cape Town and UCT Lung Institute, Cape Town, South Africa.; South African MRC Centre for the Study of Antimicrobial Resistance., Perumal T; Centre for Lung Infection and Immunity, Division of Pulmonology, Department of Medicine, University of Cape Town and UCT Lung Institute, Cape Town, South Africa.; South African MRC Centre for the Study of Antimicrobial Resistance., Scott AJ; Centre for Lung Infection and Immunity, Division of Pulmonology, Department of Medicine, University of Cape Town and UCT Lung Institute, Cape Town, South Africa.; South African MRC Centre for the Study of Antimicrobial Resistance., Hale MJ; Division of Anatomical Pathology., Baillie V; South African Medical Research Council, Vaccines and Infectious Diseases Analytics Research Unit, and.; Department of Science and Technology/National Research Foundation South African Research Chair Initiative in Vaccine Preventable Diseases, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa., Mahtab S; South African Medical Research Council, Vaccines and Infectious Diseases Analytics Research Unit, and.; Department of Science and Technology/National Research Foundation South African Research Chair Initiative in Vaccine Preventable Diseases, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa., Williamson C; Division of Medical Virology., Joseph R; Division of Medical Virology., Sigal A; Africa Health Research Institute, Durban, South Africa; and., Joubert I; Division of Critical Care, Department of Anaesthesia and Perioperative Medicine, University of Cape Town, Cape Town, South Africa., Piercy J; Division of Critical Care, Department of Anaesthesia and Perioperative Medicine, University of Cape Town, Cape Town, South Africa., Thomson D; Division of Critical Care, Department of Anaesthesia and Perioperative Medicine, University of Cape Town, Cape Town, South Africa., Fredericks DL; Division of Critical Care, Department of Anaesthesia and Perioperative Medicine, University of Cape Town, Cape Town, South Africa., Miller MGA; Division of Critical Care, Department of Anaesthesia and Perioperative Medicine, University of Cape Town, Cape Town, South Africa., Nunes MC; South African Medical Research Council, Vaccines and Infectious Diseases Analytics Research Unit, and.; Department of Science and Technology/National Research Foundation South African Research Chair Initiative in Vaccine Preventable Diseases, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa.; Centre of Excellence in Respiratory Pathogens, Hospices Civils de Lyon and Centre International de Recherche en Infectiologie, Équipe Santé Publique, Épidémiologie et Écologie Évolutive des Maladies Infectieuses, Inserm U1111, CNRS UMR5308, ENS de Lyon, Université Claude Bernard - Lyon 1, Lyon, France., Madhi SA; South African Medical Research Council, Vaccines and Infectious Diseases Analytics Research Unit, and.; Department of Science and Technology/National Research Foundation South African Research Chair Initiative in Vaccine Preventable Diseases, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa., Dheda K; Centre for Lung Infection and Immunity, Division of Pulmonology, Department of Medicine, University of Cape Town and UCT Lung Institute, Cape Town, South Africa.; South African MRC Centre for the Study of Antimicrobial Resistance.; Institute of Infectious Disease and Molecular Medicine.; Faculty of Infectious and Tropical Diseases, Department of Immunology and Infection, London School of Hygiene & Tropical Medicine, London, United Kingdom.

Publikováno v: American journal of respiratory and critical care medicine [Am J Respir Crit Care Med] 2024 Apr 01; Vol. 209 (7), pp. 840-851.