Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Apurva T. Prabhakar"'
Autor:
Apurva T. Prabhakar, Claire D. James, Aya H. Youssef, Reafa A. Hossain, Ronald D. Hill, Molly L. Bristol, Xu Wang, Aanchal Dubey, Elmira Karimi, Iain M. Morgan
Publikováno v:
mBio, Vol 15, Iss 6 (2024)
ABSTRACT An interaction between human papillomavirus 16 (HPV16) E2 and the cellular proteins TopBP1 and BRD4 is required for E2 plasmid segregation function. The E2-TopBP1 interaction promotes increased mitotic E2 protein levels in U2OS and N/Tert-1
Externí odkaz:
https://doaj.org/article/cc2d3d7b83b741e1ac3ebaebf5721fc8
Autor:
Christian T. Fontan, Claire D. James, Apurva T. Prabhakar, Molly L. Bristol, Raymonde Otoa, Xu Wang, Elmira Karimi, Pavithra Rajagopalan, Devraj Basu, Iain M. Morgan
Publikováno v:
Microbiology Spectrum, Vol 10, Iss 3 (2022)
ABSTRACT Human papillomaviruses (HPV) are causative agents in ano-genital and oral cancers; HPV16 is the most prevalent type detected in human cancers. The HPV16 E6 protein targets p53 for proteasomal degradation to facilitate proliferation of the HP
Externí odkaz:
https://doaj.org/article/5c1ee0e73e2c4d9dac09803d585872c2
Autor:
Apurva T. Prabhakar, Claire D. James, Dipon Das, Raymonde Otoa, Matthew Day, John Burgner, Christian T. Fontan, Xu Wang, Sarah H. Glass, Andreas Wieland, Mary M. Donaldson, Molly L. Bristol, Renfeng Li, Anthony W. Oliver, Laurence H. Pearl, Brian O. Smith, Iain M. Morgan
Publikováno v:
mBio, Vol 12, Iss 5 (2021)
Human papillomaviruses are causative agents in around 5% of all cancers, with no specific antiviral therapeutics available for treating infections or resultant cancers. In this report, we demonstrate that phosphorylation of HPV16 E2 by CK2 promotes f
Externí odkaz:
https://doaj.org/article/198e33f511a84547b225bf38fd4332b1
Autor:
Claire D. James, Christian T. Fontan, Raymonde Otoa, Dipon Das, Apurva T. Prabhakar, Xu Wang, Molly L. Bristol, Iain M. Morgan
Publikováno v:
mSphere, Vol 5, Iss 1 (2020)
ABSTRACT Human papillomaviruses (HPV) are causative agents in 5% of all cancers, including the majority of anogenital and oropharyngeal cancers. Downregulation of innate immune genes (IIGs) by HPV to promote the viral life cycle is well documented; E
Externí odkaz:
https://doaj.org/article/bc3fbafcef0743e69b094470b763b5c5
Autor:
Claire D. James, Apurva T. Prabhakar, Raymonde Otoa, Michael R. Evans, Xu Wang, Molly L. Bristol, Kun Zhang, Renfeng Li, Iain M. Morgan
Publikováno v:
mSphere, Vol 4, Iss 4 (2019)
ABSTRACT Human papillomaviruses induce a host of anogenital cancers, as well as oropharyngeal cancer (HPV+OPC); human papillomavirus 16 (HPV16) is causative in around 90% of HPV+OPC cases. Using telomerase reverse transcriptase (TERT) immortalized fo
Externí odkaz:
https://doaj.org/article/e19dd57447874452a7dbf5de97248421
Autor:
Apurva T. Prabhakar, Claire D. James, Christian T. Fontan, Raymonde Otoa, Xu Wang, Molly L. Bristol, Ronald D. Hill, Aanchal Dubey, Iain M. Morgan
Publikováno v:
bioRxiv
CK2 phosphorylation of HPV16 E2 at serine 23 promotes interaction with TopBP1, and this interaction is important for E2 plasmid segregation function. Here we demonstrate that the E2-TopBP1 interaction is critical for E2 and viral genome stability dur
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b5911d5e7c435ea1144a65b8296a21a0
https://doi.org/10.1101/2023.01.11.523702
https://doi.org/10.1101/2023.01.11.523702
Autor:
Apurva T. Prabhakar, Claire D. James, Dipon Das, Christian T. Fontan, Raymonde Otoa, Xu Wang, Molly L. Bristol, Iain M. Morgan
Publikováno v:
Journal of Virology. 96
Human papillomavirus 16 (HPV16) E2 is a DNA-binding protein that regulates transcription, replication and potentially, segregation of the HPV16 genome during the viral life cycle. In the segregation model, E2 simultaneously binds to viral and host ch
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2ae466e131a637fb43fa7d2b51e8286e
https://doi.org/10.1128/jvi.00830-22
https://doi.org/10.1128/jvi.00830-22
Autor:
Christian T. Fontan, Apurva T. Prabhakar, Xu Wang, Elmira Karimi, Molly L. Bristol, Claire D. James, Iain M. Morgan
Publikováno v:
Virology. 575
Following infection by HPV16, the viral proteins E1 and E2 induce viral genome replication in association with host factors. Here we demonstrate that E2 also plays a role in promoting short-term cellular proliferation in the presence of an active DDR
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::689d782ff33d023689aafb423b795dc7
https://pubmed.ncbi.nlm.nih.gov/36058086
https://pubmed.ncbi.nlm.nih.gov/36058086
Autor:
Apurva T. Prabhakar, Claire D. James, Dipon Das, Christian T. Fontan, Raymonde Otoa, Xu Wang, Molly L. Bristol, Iain M. Morgan
Human papillomavirus 16 (HPV16) E2 is a DNA binding protein that regulates transcription, replication and potentially, segregation of the HPV16 genome during the viral life cycle. In the segregation model, E2 simultaneously binds to viral and host ch
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d0e3f787ee2ca14862c7223f09dd0ab0
https://doi.org/10.1101/2022.01.28.478274
https://doi.org/10.1101/2022.01.28.478274
Autor:
Xu Wang, Iain M. Morgan, Apurva T. Prabhakar, Elmira Karimi, Molly L. Bristol, Claire D. James, Pavithra Rajagopalan, Devraj Basu, Christian T. Fontan, Raymonde Otoa
Human papillomaviruses (HPV) are causative agents in ano-genital and oral cancers; HPV16 is the most prevalent type detected in human cancers. The HPV16 E6 protein targets p53 for proteasomal degradation to facilitate proliferation of the HPV16 infec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7730de0266b46e21d6652e16354856d2
https://doi.org/10.1101/2021.11.01.466861
https://doi.org/10.1101/2021.11.01.466861