Zobrazeno 1 - 10
of 41
pro vyhledávání: '"Apurva S Chitre"'
Autor:
Alexander F Gileta, Christopher J Fitzpatrick, Apurva S Chitre, Celine L St Pierre, Elizabeth V Joyce, Rachael J Maguire, Africa M McLeod, Natalia M Gonzales, April E Williams, Jonathan D Morrow, Terry E Robinson, Shelly B Flagel, Abraham A Palmer
Publikováno v:
PLoS Genetics, Vol 18, Iss 5, p e1010234 (2022)
Sprague Dawley (SD) rats are among the most widely used outbred laboratory rat populations. Despite this, the genetic characteristics of SD rats have not been clearly described, and SD rats are rarely used for experiments aimed at exploring genotype-
Externí odkaz:
https://doaj.org/article/981971953836450d8c94637971471c7b
Autor:
Sandra Batista, Vered Senderovich Madar, Philip J. Freda, Priyanka Bhandary, Attri Ghosh, Nicholas Matsumoto, Apurva S. Chitre, Abraham A. Palmer, Jason H. Moore
Publikováno v:
BioData Mining, Vol 17, Iss 1, Pp 1-37 (2024)
Abstract Purpose Epistasis, the interaction between two or more genes, is integral to the study of genetics and is present throughout nature. Yet, it is seldom fully explored as most approaches primarily focus on single-locus effects, partly because
Externí odkaz:
https://doaj.org/article/1366e57e410d486ebca558fd373f3588
Autor:
Keita Ishiwari, Christopher P. King, Connor D. Martin, Jordan A. Tripi, Anthony M. George, Alexander C. Lamparelli, Apurva S. Chitre, Oksana Polesskaya, Jerry B. Richards, Leah C. Solberg Woods, Amy M. Gancarz, Abraham A. Palmer, David M. Dietz, Suzanne H. Mitchell, Paul J. Meyer
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-20 (2024)
Abstract Organisms must regulate their behavior flexibly in the face of environmental challenges. Failure can lead to a host of maladaptive behavioral traits associated with a range of neuropsychiatric disorders, including attention deficit hyperacti
Externí odkaz:
https://doaj.org/article/586ad7aa872542d0899cd03f7eb3bb9d
Autor:
Philip J. Freda, Attri Ghosh, Elizabeth Zhang, Tianhao Luo, Apurva S. Chitre, Oksana Polesskaya, Celine L. St. Pierre, Jianjun Gao, Connor D. Martin, Hao Chen, Angel G. Garcia-Martinez, Tengfei Wang, Wenyan Han, Keita Ishiwari, Paul Meyer, Alexander Lamparelli, Christopher P. King, Abraham A. Palmer, Ruowang Li, Jason H. Moore
Publikováno v:
BioData Mining, Vol 16, Iss 1, Pp 1-24 (2023)
Abstract Background Quantitative Trait Locus (QTL) analysis and Genome-Wide Association Studies (GWAS) have the power to identify variants that capture significant levels of phenotypic variance in complex traits. However, effort and time are required
Externí odkaz:
https://doaj.org/article/dcc3146814494167aea71969b53c347c
Autor:
Sarah N. Wright, Brittany S. Leger, Sara Brin Rosenthal, Sophie N. Liu, Tongqiu Jia, Apurva S. Chitre, Oksana Polesskaya, Katie Holl, Jianjun Gao, Riyan Cheng, Angel Garcia Martinez, Anthony George, Alexander F. Gileta, Wenyan Han, Alesa H. Netzley, Christopher P. King, Alexander Lamparelli, Connor Martin, Celine L. St. Pierre, Tengfei Wang, Hannah Bimschleger, Jerry Richards, Keita Ishiwari, Hao Chen, Shelly B. Flagel, Paul Meyer, Terry E. Robinson, Leah C. Solberg Woods, Jason F. Kreisberg, Trey Ideker, Abraham A. Palmer
Publikováno v:
Cell Reports, Vol 42, Iss 8, Pp 112873- (2023)
Summary: A vexing observation in genome-wide association studies (GWASs) is that parallel analyses in different species may not identify orthologous genes. Here, we demonstrate that cross-species translation of GWASs can be greatly improved by an ana
Externí odkaz:
https://doaj.org/article/40d23e0993024b1ea31e653650c9f892
Autor:
Samuel Fowler, Tengfei Wang, Daniel Munro, Aman Kumar, Apurva S. Chitre, T. J. Hollingsworth, Angel Garcia Martinez, Celine L. St. Pierre, Hannah Bimschleger, Jianjun Gao, Riyan Cheng, Pejman Mohammadi, Hao Chen, Abraham A. Palmer, Oksana Polesskaya, Monica M. Jablonski
Publikováno v:
Frontiers in Genetics, Vol 13 (2023)
Elevated intraocular pressure (IOP) is influenced by environmental and genetic factors. Increased IOP is a major risk factor for most types of glaucoma, including primary open angle glaucoma (POAG). Investigating the genetic basis of IOP may lead to
Externí odkaz:
https://doaj.org/article/f112d5721f474737b04bad488f8e2f87
Autor:
Apurva S. Chitre, Elaine K. Hebda-Bauer, Peter Blandino, Hannah Bimschleger, Khai-Minh Nguyen, Pamela Maras, Fei Li, A. Bilge Ozel, Yanchao Pan, Oksana Polesskaya, Riyan Cheng, Shelly B. Flagel, Stanley J. Watson, Jun Li, Huda Akil, Abraham A. Palmer
Publikováno v:
Frontiers in Genetics, Vol 13 (2023)
Common genetic factors likely contribute to multiple psychiatric diseases including mood and substance use disorders. Certain stable, heritable traits reflecting temperament, termed externalizing or internalizing, play a large role in modulating vuln
Externí odkaz:
https://doaj.org/article/b0175e27439b4411910c8a5f75b7f566
Autor:
Christopher P. King, Jordan A. Tripi, Alesa R. Hughson, Aidan P. Horvath, Alexander C. Lamparelli, Katie L. Holl, Apurva S. Chitre, Oksana Polesskaya, Keita Ishiwari, Leah C. Solberg Woods, Abraham A. Palmer, Terry E. Robinson, Shelly B. Flagel, Paul J. Meyer
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-17 (2021)
Abstract Sensitivity to cocaine and its associated stimuli (“cues”) are important factors in the development and maintenance of addiction. Rodent studies suggest that this sensitivity is related, in part, to the propensity to attribute incentive
Externí odkaz:
https://doaj.org/article/1966665f7b7c41679e07bd86e26a9015
Autor:
Mustafa Hakan Gunturkun, Tengfei Wang, Apurva S. Chitre, Angel Garcia Martinez, Katie Holl, Celine St. Pierre, Hannah Bimschleger, Jianjun Gao, Riyan Cheng, Oksana Polesskaya, Leah C. Solberg Woods, Abraham A. Palmer, Hao Chen
Publikováno v:
Frontiers in Psychiatry, Vol 13 (2022)
Many personality traits are influenced by genetic factors. Rodents models provide an efficient system for analyzing genetic contribution to these traits. Using 1,246 adolescent heterogeneous stock (HS) male and female rats, we conducted a genome-wide
Externí odkaz:
https://doaj.org/article/c1e5e99160124ae79fd09f4a4c36e7a3
Autor:
Alexander F. Gileta, Jianjun Gao, Apurva S. Chitre, Hannah V. Bimschleger, Celine L. St. Pierre, Shyam Gopalakrishnan, Abraham A. Palmer
Publikováno v:
G3: Genes, Genomes, Genetics, Vol 10, Iss 7, Pp 2195-2205 (2020)
The heterogeneous stock (HS) is an outbred rat population derived from eight inbred rat strains. HS rats are ideally suited for genome wide association studies; however, only a few genotyping microarrays have ever been designed for rats and none of t
Externí odkaz:
https://doaj.org/article/3aa4bd3693ad45488193d7ee910dee76