Species-specific self-DNA detection mechanisms by mammalian cyclic GMP-AMP synthases

Autor: Kenta Mosallanejad, Stephanie N. Kennedy, Kristin M. Bahleda, Kailey M. Slavik, Wen Zhou, Apurva A. Govande, Dustin C. Hancks, Philip J. Kranzusch, Jonathan C. Kagan

Publikováno v: Science Immunology. 8

The mechanisms by which innate immune receptors mediate self-nonself discrimination are unclear. In this study, we found species-specific molecular determinants of self-DNA reactivity by cyclic guanosine monophosphate–adenosine monophosphate (GMP�

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::1591a49af567c168ab3cd335b9281163
https://doi.org/10.1126/sciimmunol.abp9765

Three functionally distinct classes of cGAS proteins in nature revealed by self-DNA-induced interferon responses

Autor: Kenta Mosallanejad, Wen Zhou, Apurva A. Govande, Dustin C. Hancks, Philip J. Kranzusch, Jonathan C. Kagan

Innate immune pattern recognition receptors (PRRs) emerged early in evolution. It is generally assumed that structurally homologous proteins in distinct species will operate via similar mechanisms. We tested this prediction through the study of inter

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::236d7db1644472d8679d9a4b20b66d38
https://doi.org/10.1101/2022.03.09.483681

Molecular basis of CD-NTase nucleotide selection in CBASS anti-phage defense

Autor: Brianna Duncan-Lowey, James B. Eaglesham, Apurva A. Govande, Aaron T. Whiteley, Philip J. Kranzusch

Publikováno v: Cell Reports. 35:109206

cGAS/DncV-like nucleotidyltransferase (CD-NTase) enzymes are signaling proteins that initiate antiviral immunity in animal cells and cyclic-oligonucleotide-based anti-phage signaling system (CBASS) phage defense in bacteria. Upon phage recognition, b

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fb0fe109eb61199542c358430f3f3bfd
https://doi.org/10.1016/j.celrep.2021.109206

MYC Controls the Epstein-Barr Virus Lytic Switch.

Autor: Guo R; Division of Infectious Disease, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA; Department of Microbiology, Harvard Medical School, Boston, MA 02115, USA; Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA., Jiang C; Division of Infectious Disease, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA; Department of Microbiology, Harvard Medical School, Boston, MA 02115, USA; Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA., Zhang Y; Division of Infectious Disease, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA; Department of Microbiology, Harvard Medical School, Boston, MA 02115, USA; Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA; Sun Yat-sen University Cancer Center, Guangzhou 510060, China., Govande A; Harvard Graduate Program in Virology, Boston, MA 02115, USA., Trudeau SJ; Division of Infectious Disease, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA; Department of Microbiology, Harvard Medical School, Boston, MA 02115, USA; Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA., Chen F; Cell Signaling Technology, Inc., Danvers, MA 01923, USA., Fry CJ; Cell Signaling Technology, Inc., Danvers, MA 01923, USA., Puri R; Department of Biomedical Sciences, College of Veterinary Medicine, Cornell University, Ithaca, NY 14853, USA., Wolinsky E; Division of Infectious Disease, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA; Department of Microbiology, Harvard Medical School, Boston, MA 02115, USA; Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA., Schineller M; Division of Infectious Disease, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA; Department of Microbiology, Harvard Medical School, Boston, MA 02115, USA; Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA., Frost TC; Harvard Graduate Program in Virology, Boston, MA 02115, USA., Gebre M; Harvard Graduate Program in Virology, Boston, MA 02115, USA., Zhao B; Division of Infectious Disease, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA., Giulino-Roth L; Division of Pediatric Hematology/Oncology, Weill Cornell Medical College, New York, NY 10065, USA., Doench JG; Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA., Teng M; Department of Biostatistics and Bioinformatics, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL 33612, USA. Electronic address: mingxiang.teng@moffitt.org., Gewurz BE; Division of Infectious Disease, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA; Department of Microbiology, Harvard Medical School, Boston, MA 02115, USA; Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA; Harvard Graduate Program in Virology, Boston, MA 02115, USA. Electronic address: bgewurz@bwh.harvard.edu.

Publikováno v: Molecular cell [Mol Cell] 2020 May 21; Vol. 78 (4), pp. 653-669.e8. Date of Electronic Publication: 2020 Apr 20.