Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Apurba K. Gayen"'
Autor:
Apurba K. Gayen, Dennis M. Peffley
Publikováno v:
The Journal of Nutrition. 133:38-44
The rate-limiting enzyme for mevalonate and cholesterol synthesis in mammalian cells is 3-hydroxy-3-methylglutaryl-CoA (HMG-CoA) reductase. Control occurs through both transcriptional and post-transcriptional actions signaled by the end product, chol
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::46b964905c1703f69d13a21856462905
https://doi.org/10.1093/jn/133.1.38
https://doi.org/10.1093/jn/133.1.38
Publikováno v:
Biochemical Pharmacology. 56:439-449
In vivo inhibition of 2,3-oxidosqualene:lanosterol cyclase (OSC, E.C. 5.4.99.7)--the enzyme which catalyzes the cyclization of monooxidosqualene to lanosterol--does not result in elevated 3-hydroxy-3-methylglutaryl CoA reductase (HMGR) activity. This
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0cfade34fa743465b73df672c1c32d79
https://doi.org/10.1016/s0006-2952(98)00083-5
https://doi.org/10.1016/s0006-2952(98)00083-5
Autor:
Dennis M. Peffley, Apurba K. Gayen
Publikováno v:
Archives of Biochemistry and Biophysics. 337:251-260
Previously, we found that mevalonate-derived products together with an oxysterol regulated reductase synthesis at a posttranscriptional level. To determine which products were responsible for this regulation, either the squalene synthase inhibitor za
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eb49958f75551468da9efc366575c16e
https://doi.org/10.1006/abbi.1996.9796
https://doi.org/10.1006/abbi.1996.9796
Autor:
Dennis M. Peffley, Apurba K. Gayen
Publikováno v:
Archives of Biochemistry and Biophysics. 322:475-485
Transcripts for hamster 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase are heterogeneous in length. This heterogeneity is due to variations in the length of 5′-untranslated leader (UTL) sequences, which are generated by both alternate sp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0810a6c866d3e97b32dbb36a0fec0d21
https://doi.org/10.1006/abbi.1995.1491
https://doi.org/10.1006/abbi.1995.1491
Autor:
Dennis M. Peffley, Apurba K. Gayen
Publikováno v:
Somatic Cell and Molecular Genetics. 21:189-204
We reported previously that 3-hydroxy-3-methylglutaryl coenzyme A reductase synthesis is regulated at the translational level by mevalonate. To determine at what stage mevalonate affects reductase synthesis, we examined the distribution of reductase
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8c24e040ae465b7f612a040cd316294a
https://doi.org/10.1007/bf02254770
https://doi.org/10.1007/bf02254770
Publikováno v:
The Journal of biological chemistry. 272(10)
Recent data indicate that sterol carrier protein-2 (SCP-2) functions in the rapid movement of newly synthesized cholesterol to the plasma membrane (Puglielli, L., Rigotti, A., Greco, A. V., Santos, M. J., and Nervi, F. (1995) J. Biol. Chem. 270, 1872
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::78a54a11d906f07e73ae27fe0f4ebcd0
https://pubmed.ncbi.nlm.nih.gov/9045674
https://pubmed.ncbi.nlm.nih.gov/9045674
Autor:
Apurba K. Gayen, Charles O. Knowles
Publikováno v:
Entomologia Experimentalis et Applicata. 31:285-290
Methomyl insecticide was appreciably more toxic to non-diapause larvae (NDL) than to environmentally induced diapause larvae (EIL) of the southwestern corn borer when applied topically (84.8 times) or by injection (18.5 times). Although differential
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c8e3562ddf9917f5bd69df5b5e5d5dae
https://doi.org/10.1111/j.1570-7458.1982.tb03146.x
https://doi.org/10.1111/j.1570-7458.1982.tb03146.x
Publikováno v:
Bioorganic Chemistry. 17:108-120
Azadecalins 4, 7, 8, 9 and 10 have been synthesized and tested as inhibitors of oxidosqualene cyclase in a rat liver microsomal assay. These compounds, which structurally resemble the known cyclase inhibitor 4,4,10β-trimethyl- trans -decal-3β-ol (T
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cea8fcba7efcf2fdea3d60616c5d185c
https://doi.org/10.1016/0045-2068(89)90012-6
https://doi.org/10.1016/0045-2068(89)90012-6
Publikováno v:
Entomologia Experimentalis et Applicata. 34:308-316
Penetration of six formamidines into and through the isolated abdominal cuticles of nondiapausing (NDL), environmentally induced diapausing (EIL), and hormonally induced diapausing (HIL) southwestern corn borer larvae was assessed by means of a two c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::46de54c3ed33451fc6acf5331ad50828
https://doi.org/10.1111/j.1570-7458.1983.tb03340.x
https://doi.org/10.1111/j.1570-7458.1983.tb03340.x
Publikováno v:
Nature Biotechnology. 1:62-65
The 29–fluorophytosterols, members of a new class of selective pro–insecticides, have been synthesized and examined in vivo in tobacco hornworms. Dealkylation at C–24 of the steroid side chain by insects releases the latent poison fluoroacetate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b305ad6634f930f40e1ef40c2cc480b9
https://doi.org/10.1038/nbt0383-62
https://doi.org/10.1038/nbt0383-62