Zobrazeno 1 - 4
of 4
pro vyhledávání: '"April Thelemann"'
Autor:
Andrew P. Crew, Meizhong Jin, Kristen Michelle Mulvihill, Mark J. Mulvihill, David Epstein, Qun-Sheng Ji, Shripad V. Bhagwat, Mridula Kadalbajoo, Andrew Cooke, Josef A. Rechka, Jonathan A. Pachter, Mark Bittner, Kam W. Siu, Yan Yao, Jing Wang, April Thelemann, Andrew Kleinberg
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 23:979-984
This Letter describes the medicinal chemistry effort towards a series of novel imidazo[1,5-a]pyrazine derived inhibitors of ACK1. Virtual screening led to the discovery of the initial hit, and subsequent exploration of structure-activity relationship
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fb66157d50668f15d12c6b4c68463b3f
https://doi.org/10.1016/j.bmcl.2012.12.042
https://doi.org/10.1016/j.bmcl.2012.12.042
Autor:
Laura Sullivan, Tony Hunt, Jen Kahler, Andrew Garton, April Thelemann, Linda Castaldo, Siobhan McCormack, Lynn Zeiske, Herbert Haack, Lydia Nuwaysir, John D. Haley, Filippo Petti
Publikováno v:
Molecular cancer therapeutics. 4(8)
OSI-930, a potent thiophene inhibitor of the Kit, KDR, and platelet-derived growth factor receptor tyrosine kinases, was used to selectively inhibit tyrosine phosphorylation downstream of juxtamembrane mutant Kit in the mast cell leukemia line HMC-1.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d9047b6127f77f00f499c49d8937b6d8
https://pubmed.ncbi.nlm.nih.gov/16093434
https://pubmed.ncbi.nlm.nih.gov/16093434
Autor:
Tina Settinari, April Thelemann, John D. Haley, Graeme Griffin, Neil W. Gibson, Filippo Petti, David Fenyö, K K Iwata, Tony Hunt
Publikováno v:
Molecularcellular proteomics : MCP. 4(4)
Overexpression and enhanced activation of the epidermal growth factor (EGF) receptor are frequent events in human cancers that correlate with poor prognosis. Anti-phosphotyrosine and anti-EGFr affinity chromatography, isotope-coded muLC-MS/MS, and im
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ffcbebf37e2125b6907abfa35a3f2445
https://pubmed.ncbi.nlm.nih.gov/15657067
https://pubmed.ncbi.nlm.nih.gov/15657067
Autor:
Andrew P. Crew, Shripad V. Bhagwat, Mark J. Mulvihill, David Epstein, Andrew Cooke, Yan Yao, Mark Bittner, Qun-Sheng Ji, Meizhong Jin, Andrew Kleinberg, Jing Wang, April Thelemann, Josef A. Rechka, Jonathan A. Pachter, Kam W. Siu, Mridula Kadalbajoo, Kristen Michelle Mulvihill
Publikováno v:
Cancer Research. 73:2463-2463
Activated Cdc42-associated kinase (ACK1) is a non-receptor tyrosine kinase originally identified by virtue of its binding to GTP-bound small GTPase Cdc42. Considerable attention has been paid to ACK1’s involvement in cancer in recent years. For exa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0728effeee04557a92dd1ee775962d49
https://doi.org/10.1158/1538-7445.am2013-2463
https://doi.org/10.1158/1538-7445.am2013-2463